BLTS0411p Immunohaematology and Blood Banking - lecture

Faculty of Medicine
spring 2022
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
RNDr. Libuše Janků (lecturer)
MUDr. Hana Lejdarová, Ph.D., MBA (lecturer), doc. MUDr. Milan Dastych, CSc., MBA (deputy)
Mgr. Martina Adamcová (assistant)
Michaela Gregorovičová (assistant)
Guaranteed by
MUDr. Hana Lejdarová, Ph.D., MBA
Department of Laboratory Methods – Departments of Non-medical Branches – Faculty of Medicine
Contact Person: Mgr. Martina Adamcová
Supplier department: Department of Laboratory Methods – Departments of Non-medical Branches – Faculty of Medicine
Timetable
Mon 14. 2. 7:00–8:40 N01231, Mon 21. 2. 7:00–8:40 N01231, Mon 28. 2. 7:00–8:40 N01231, Mon 7. 3. 7:00–8:40 N01231, Mon 14. 3. 7:00–8:40 N01231, Mon 21. 3. 7:00–8:40 N01231, Mon 28. 3. 7:00–8:40 N01231, Mon 4. 4. 7:00–8:40 N01231, Mon 11. 4. 7:00–8:40 N01231, Mon 25. 4. 7:00–8:40 N01231, Mon 2. 5. 7:00–8:40 N01231, Mon 9. 5. 7:00–8:40 N01231, Mon 16. 5. 7:00–8:40 N01231, Mon 23. 5. 7:00–8:40 N01231
Prerequisites (in Czech)
BLKH0311c Clinical Haematology - pract.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Course main objectives The aim of theoretical part of education in immunohaematology is given to understand separate laboratory procedures principles which are currently used in immunohaematology and acquirement of knowledge in relation to its application in laboratory praxis. The accent is putting on ability of separate laboratory results interpretation and/or group laboratory results interpretation to clinical patient hood. Professional theoretical training in HLA covers laboratory testing HLA complex and laboratory results interpretation in relation to solid organs transplant strategy and in relation to strategy of bone marrow donors registry as far as laboratory results interpretation in relation to immunized patients. Theoretical part of education of transfusion service covers background and principles of good manufacturing praxis in preparation, use and quality assurance of transfusion products (allogeneic, autologous) and plasma for fractionation, including quality management and process control, personnel and organisation, equipment and materials, documentation, donor selection, processing, storage and distribution, quality monitoring, quality control, contract management, deviations, complaints, corrective and preventive actions, self inspection, audits and improvement, data processing systems, record keeping, statistical process control, background of safe haemotherapy, principles of haemovigilance system, including types of adverse reactions description and its reporting.
Learning outcomes
After course completing programme the student will be able: - transfusion service legislation orientate, - respect principles of good laboratory praxis and good manufacturing praxis, - know principles of haemovigilace and haemotherapy, - qualify accuracy of indication and interpretation of immunohaematology laboratory results, - recognize cases for following testing, - analytic methods orientate.
Syllabus
  • Laboratory theory Introduction, definition of immunohaematology, HLA, transfusion service ; Laboratory diagnostics in immunohaematology ; Red blood cell antigens and antibodies, background of blood groups inheritance ; AB0 blood group system, discovery and development of blood group knowledge, state of art, possibilities of detection, importance, ; Lewis blood group system, secretor status ; Rh blood group system ; Others blood group systems, low-prevalence, high-prevalence antigens ; Clinical significance of blood group antibodies, medical aspects, laboratory procedure, screening and identification, selection, crossmatching ; Leucocytes and platelets antigens, production of antibodies and its medical aspects, possibilities of laboratory detection ; Laboratory diagnostics in HLA ; HLA system, medical aspects of HLA antigens, HLA antibodies ; HLA system link to solid organs transplant strategy and bone marrow donors registry; Background of good laboratory praxis ; Internal and external quality process control; Preanalytic, analytic and postanalytic fasis of laboratory procedure ; Good manufacturing praxis in preparation, use and quality assurance of transfusion products (allogeneic, autogenous) and plasma for fractionation,; Transfusion preparations, blood derivates, definition, indication for clinical use ; Plasma for fractionation, definition ; Blood collection, testing ; Autologous transfusion preparations; Legislature on transfusion service, audits of state authority; Organisation of transfusion service in Czech republic ; Data processing systems, record keeping, background of on-line data transfers ; Statistical process control ; Clinical theory ; Safe haemotherapy, ordering and administration, transfusion equipment, uses and contraindications, expected response and potential adverse effects, alternatives to allogeneic transfusion, registry of rare blood group donors; Transfusion management of infants and children, haemolytic disease of foetus and newborn, AB0 and Rh incompatibility, others blood group incompatibility special requirements for intrauterine and neonatal transfusions ; Autoimmune haemolytic anaemia, definition, medical aspects, selection, laboratory testing, safe transfusion, options of haemotherapy ; Acute and delayed transfusion reactions, laboratory findings, clinical evaluation at the bedside; Principles and usage of specific laboratory testing in immunohaematology, absorbing tests, elution techniques, neutralising tests; Quality assurance in immunohaematology; Trouble-shooting and problem-solving in laboratory ; Transplant of bone marrow and haemotherapy blood group conversion ; Infectious complications of transfusion ; Informed consent for transfusion, lookback and recipient notification and product recall and withdrawls ; Haemovigilance system, transfusion committee, process improvement;
Literature
  • Transfuzní lékařství. Edited by Vít Řeháček - Jiří Masopust. 1. vyd. Praha: Grada, 2013, 237 s. ISBN 9788024745343. info
  • PENKA, Miroslav and Eva TESAŘOVÁ. Hematologie a transfuzní lékařství II. 1st ed. Praha: Grada Publishing, 2012, p. 95 - 102. ISBN 978-80-247-3460-6. info
Teaching methods
- audiovisual lectures (pp-presentations), - excursions to laboratory and manufacturing spaces - technical handbook, - professional discussion.
Assessment methods
Oral exam.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
Information on the extent and intensity of the course: 30.
The course is also listed under the following terms Spring 2007, Spring 2008, Autumn 2008, Spring 2009, Autumn 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021.
  • Enrolment Statistics (recent)
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