BLMB011p Molecular and Cellular Biology - lecture

Faculty of Medicine
autumn 2023
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Francová, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Kateřina Straková, Ph.D. (lecturer)
doc. Mgr. Jiří Šána, Ph.D. (lecturer)
Mgr. Lenka Bešše, Ph.D. (lecturer)
Jana Růžičková (assistant)
Guaranteed by
prof. RNDr. Ondřej Slabý, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Ing. Lívia Eiselleová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Tue 15:10–16:50 B11/334
Prerequisites
Knowledge high-school biology on the level of Overview of High School Biology (https://is.muni.cz/auth/do/med/el/overview/overview_CZ.qwarp) or similar.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding the chemical composition, structure and properties of the main cellular components
- understanding the basic processes in the cell; and understanding the principles of pathology of these processes in cancer and genetic diseases
- understanding the basic principles of heredity
Learning outcomes
After completing the course the student will be able to:
- describe the composition, structure and functions of prokaryotic and eukaryotic cells
- Explain the principles of intercellular communication and cell differentiation
- Explain the principles of regulation and purpose of cell division (mitosis and meiosis)
- explain basic principles of heredity and nature of human genetic diseases, describe basic methods of gene diagnostics
- Explain the principles of tumour transformation
Syllabus
  • Week 1: Introduction. Basic properties of living organisms. Proteins and their functions
  • Week 2: Bacteria and viruses. Human microbiome
  • Week 3: Architecture and function of eukaryotic cell
  • Week 4: Nucleic acids. Structure of chromosomes. DNA replication
  • Week 5: DNA damage and repair, cell death
  • Week 6: From genes to proteins – expression of genetic information
  • Week 7: Cell signalling. Cell differentiation. Stem cells
  • Week 8: Cytoskeletal system of cells and principles of cell organization in tissues
  • Week 9: Cell cycle and mitosis, regulation of cell division
  • Week 10: Meiosis and gametogenesis. Karyotype, chromosomal aberrations
  • Week 11: Genes and gene mutations - Mendelian and non-Mendelian inheritance
  • Week 12: Malignant transformation of cells. Cancer
  • Week 13: Methods of gene studying. Gene diagnostics, gene therapy
  • Week 14: substitution lecture
Literature
    recommended literature
  • SLABÝ, Ondřej. Lékařská biologie. 1. vydání. Brno: Masarykova univerzita, 2022, 268 stran. ISBN 9788028000608. info
  • SLABÝ, Ondřej. Lékařská biologie II. Genetika a molekulární medicína (Medical Biology II. Genetics and molecular medicine). 1st ed. Brno: Masarykova univerzita, 2023, 227 pp. ISBN 978-80-280-0338-8. info
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • PRITCHARD, D. J. and Bruce R. KORF. Základy lékařské genetiky. první české vydání. Praha: Galén, 2007, 182 stran. ISBN 9788072624492. info
Teaching methods
two-hour lecture with discussion per week
Assessment methods
The course is completed with a written examination test with 60 questions (30 multiple choice questions, where negative marking applies for incorrect answers + 30 questions where the student chooses from true/false). At least 30 points out of 60 are needed to pass. More information on the exam to be found in Interactive syllabus of the course.
The exam requires knowledge discussed at the lectures and practices. The exam tests the understanding of the discussed knowledge.
Successful passing of the subject's practice is required for attending the exam.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
Teacher's information
https://is.muni.cz/auth/el/med/podzim2023/BLMB011p/index.qwarp
You can find all important information about the course organisation, study materials, etc., in the Interactive syllabus of the course: https://is.muni.cz/auth/el/med/podzim2023/BLMB011p/index.qwarp.

When you lack understanding of some topic from the lectures, study the respective topic in the recommended text books at the extent of the syllabus, or come to discuss the problem in the consulting hours.

The course is also listed under the following terms Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2024.
  • Enrolment Statistics (autumn 2023, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2023/BLMB011p