LF:VLFA0621p Pharmacology - lect.

VLFA0621p Pharmacology I - lectures

Faculty of Medicine
Spring 2009

Extent and Intensity

2/0/0. 0 credit(s). Type of Completion: -.

Teacher(s)

Guaranteed by

prof. MUDr. Alexandra Šulcová, CSc.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Alexandra Šulcová, CSc.

Timetable

Mon 23. 2. to Fri 29. 5. Tue 13:40–15:20 P31 Posluchárna A. I. Bláhy

Prerequisites (in Czech)

VSPF0521c Pathophysiol. I - practice. && VSPA0521c Pathology - practice

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

General Medicine (eng.) (programme LF, M-VL)
General Medicine (programme LF, M-VL)

Course objectives

At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.

Syllabus

LECTURES ON PHARMACOLOGY - Spring Semester
1: Introduction to pharmacology. The scope and historical development of modern pharmacology, its position in the system of medical education.
2: Basic pharmacological terms, definitions. Types of pharmacotherapy and drug effects. Therapeutic Index. Teratogenic drug effects.
3: Drug delivery approaches, routes of administration, prolonged release preparations.
4: Mechanisms of drug action, non-specific, specific. Classical receptors and ligand binding. Receptor subtypes, autoreceptors, heteroreceptors.
5: Concentration-response relationship. Pharmacokinetic principles. Drug absorption, distribution, metabolism and elimination.
6: Pharmacogenetics. Combined drug effects.
7: Drug therapy in children, general principles, pharmacokinetic and pharmacodynamic peculiaritis. Pharmacotherapy in neonates.
8: Physiological and pathological factors influencing drug effects. Changes of drug effects after the repeated administration. Quantitative and qualitative deviations in drug effects, hypo-, and hyperergic reactions, allergy.
9: Adverse drug effects. Toxic responses. The management of poisoning.
10: Drug discovery and development, preclinical and clinical examination and evaluation. Regulation and guidelines for "Good Clinical Practice". Collaboration of experimental and clinical pharmacologists.
11: Purposeful pharmacotherapy. Importance of the pharmacological anamnesis, monitoring of drug pharmacotherapy, risk of pharmacotherapy.
12: Principles of pharmacovigilance, duties of physicians and pharmaceutical companies, general rules in drug promotion.
13: Autonomic nervous systems, mediators, overview. Adrenergic mediation, alfa and beta sympatomimetics. Ganglion blocking drugs. Myorelaxants. Pharmacology of the autonomic Enteric Nervous System.
14: Analgesics, mechanisms of morphine and acetylsalicylic acid effects. Pain control in selected states. Nicotin, side effects, toxicity, clinical problems. Therapy and prevention of nicotinism.

Literature

LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
RANG, H. P. Rang and Dale's pharmacology. 6th ed. [S.l.]: Churchill Livingstone, 2007, xiii, 829. ISBN 9780443069116. info
Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
Pharmaceutical Practice, 3rd Ed. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone, 2004, ISBN 0443 07206 X
HOWLAND, Richard D. and Mary Julia MYCEK. Pharmacology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2006, vii, 552. ISBN 0781741181. info
https://is.muni.cz/auth/el/1411/jaro2009/VLFA0621c/um/Practicals_in_Pharmacology_ENGL.pdf?fakulta=1411;obdobi=4504;kod=VLFA0621c

Teaching methods

According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.

Assessment methods

There is no testing of knowledge in this part of study as students are expected to continue pharmacological course in the subsequent semester.

Language of instruction

Czech

Further comments (probably available only in Czech)

The course is taught annually.

The course is also listed under the following terms Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017.

Enrolment Statistics (Spring 2009, recent)
Permalink: https://is.muni.cz/course/med/spring2009/VLFA0621p

LF:VLFA0621p Pharmacology - lect. - Course Information

VLFA0621p Pharmacology I - lectures

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