DSMBz01 Molecular Biology and Genetics

Faculty of Medicine
Spring 2014
Extent and Intensity
0/0/0. 5 credit(s). Recommended Type of Completion: k (colloquium). Other types of completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
Ing. Dana Dvořáková, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
Mgr. Michal Strouhal, Ph.D. (lecturer)
Mgr. Martina Vráblíková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Martina Vráblíková
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 45 student(s).
Current registration and enrolment status: enrolled: 1/45, only registered: 0/45
fields of study / plans the course is directly associated with
Course objectives
The course covers an overview of new and modern methods involved in molecular and cell biology research. It covers mainly molecular biology (regulation of gene expression, human genome, gene therapy, and cell biology (stem cells and cell therapy, cytoskeleton and molecular motors, cell cycle, apoptosis and malignant cell transformation). This information will help to better understand to new scientific topics in biology.
Syllabus
  • Molecular biology and genetics. DNA, structure, RNA structure, Proteins, structure, experimental methods. Allosteric proteins. DNA replication. RNA synthesis, transcription. protein synthesis, function of ribosome, posttranslational modifications. Inhibitors of DNA and RNA synthesis. Genetic information. Regulation of gene expression. Genetic recombination. Human genome. Genetic engineering. Molecular diagnostics of non-functional genes. Membrane structure. Cell signaling. Cytoskeleton. cell cycle. Structure of cell nucleus. Chromosome structure. Mitosis. Meiosis. Molecular principles of cell movement. gametes and fertilization. Differentiation and dedifferentiation. Apoptosis. Biology of stem cells. Applications of stem cells in medicine. Malignant cell transformation. Oncogenes, carcinoma suppressors.
Literature
    recommended literature
  • ALBERTS, B. et al.: Molecular biology of the cell, 4.vyd.Garland Publ.Inc., New York, 2002
  • ALBERTS, B. et al.: Essential cell biology, 2.vyd., Garland Publ.Inc., New York, 2004
  • BECKER,W.M. et al.: The world of the cell. 7.vyd., Benjamin Cummins Publ. Comp. New York, 2008
  • CLARK, D.P. et al., Molecular biology, Elsevier, Inc. Amsterdam – Tokyo
  • FILIP, S. et al., Kmenové buňky – biologie, medicína, filozofie, Galén Praha, 2006
  • LODISH, et al.: Molecular cell biology, 4.ed., W.H. Freeman and Company, New York, 2001
  • POLLARD,T.D., et al.: Cell Biology. Saunders, New York, 2008
  • STRACHAN, T.,READ, A.P.: Human Molecular Genetics.Bios Scientific Publishers Ltd., Oxford, 1997
  • WEINBERG, R.A.: The Biology of Cancer. Garland Science Publishing, New York, 2006
  • WOLPERT, L.et al.: Principles of development. Oxford University Press, Oxford, 2002
  • Cell death. Edited by Gerry Melino - David Vaux. 1st pub. Hoboken, NJ: Wiley-Blackwell, 2010, xi, 303. ISBN 9780470715734. info
  • ALLISON, Lizabeth A. Fundamental molecular biology. 2nd ed. Hoboken: Wiley-Blackwell, 2011, xxvi, 696. ISBN 9780470550748. info
  • Šárka Pospíšilová, Dana Dvořáková, Jiří Mayer, et al. Molekulární hematologie
Teaching methods
Lectures will be held on 21 March and 4 April 2012 at 10:00-14:00, room No.1.17, building A3 (Department of Biology), University Campus Brno Bohunice
Assessment methods
Lesson attendance is mandatory (2 blocks).
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is taught: in blocks.
Information on the extent and intensity of the course: celkem 8 hodin.
Information on course enrolment limitations: Předmět je přednostně určen pro postgraduální studenty
The course is also listed under the following terms Spring 2000, Spring 2001, Autumn 2001, Spring 2002, Autumn 2002, Spring 2003, Autumn 2003, Spring 2004, Autumn 2004, Spring 2005, Autumn 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (Spring 2014, recent)
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