DSAMolM Advanced Molecular Medicine

Faculty of Medicine
spring 2020
Extent and Intensity
2/0/0. 3 credit(s) (plus 1 for the colloquium). Type of Completion: k (colloquium).
Teacher(s)
prof. MUDr. Mgr. Marek Mráz, Ph.D. (lecturer)
Mgr. Dáša Bohačiaková, Ph.D. (lecturer)
Mgr. Vladimír Vinarský, Ph.D. (lecturer)
Mgr. Tomáš Bárta, Ph.D. (lecturer)
Guaranteed by
prof. MUDr. Mgr. Marek Mráz, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Mgr. Marek Mráz, Ph.D.
Supplier department: Central European Institute of Technology
Prerequisites
Students that enroll to this course should be PhD students at Faculty of Sciences or Faculty of Medicine (any field), or in the 2nd year of their Master studies (final year) at the Faculty of Sciences, or 5th year of their studies at Faculty of Medicine (General Medicine). Students will be asked to prepare a presentation of a major scientific publication from the field that is discussed in the course. The journal articles will be assigned by the lecturer depending on the interests of the students.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 20 student(s).
Current registration and enrolment status: enrolled: 0/20, only registered: 0/20, only registered with preference (fields directly associated with the programme): 0/20
fields of study / plans the course is directly associated with
Course objectives
The main objective is to discuss novel concepts in CANCER BIOLOGY (approx. 2 days), BASIC MOLECULAR MECHANISMS IN THE REGULATION OF HEART BIOLOGY and VISION (approx. half day), AND REGENERATIVE MEDICINE (approx. half day). The students will present and discuss selected articles relevant for the topic. The course will be thought by several experts in the field and recent high-profile articles and discoveries will be discussed: - orientation in the most recent advances in the pathogenesis and targeted therapy in cancer, focus on selecting therapy based on molecular aberrations, novel design of clinical trials (basket/umbrella trials, n=1 trials) - modern technics affecting the study and therapy in oncology, especially Crispr and Next-generation sequencing (NGS), single cell analysis - novel concepts in immunotherapy such as CAR-T cell and check-point inhibitors, and their position in oncology - role of tumor microenvironment on the progression and therapy of diseases - regenerative medicine of human heart and vision - neurodegenerative disease biology, and possibilities of studies with neuronal precursors derived from embryonic stem cells, preparation of mini-brains
Learning outcomes
Students will be exposed to the recent advances in the field of cancer biology including methodological approaches, novel concepts in the biology of heart and vision, and also regenerative medicine. They will understand the opened questions in the field, and the further directions with implications for therapy of patients. They will to learn and discuss how molecular biology contributes to disease treatment and regenerative medicine. They will have in-depth discussion with experts in the field.
Syllabus
  • 1. CANCER: Cancer Genomics to Targeted Therapies/Precision Cancer Medicine (NGS) 2. CANCER: Emerging Methods for Functional Genomic Analysis 3. CANCER: Rethinking Immunotherapeutic approaches in Cancer 4. CANCER: Non-coding RNAs in Cancer 5. CANCER: Microenvironment interactions in Cancer 6. CANCER: Advances in Patient-Derived Xenograft Modeling 7. CANCER: New Clinical Trial Design for Targeted Therapies and Use of Liquid Biopsies 8. CANCER: Biologic and Clinical Significance of Intratumoral Heterogeneity 9. CANCER: Impact of the Microbiome 10. CANCER: Cancer Modeling with CRISPR 11. CANCER: Advances in Cancer/Neo-antigen Vaccines 12. CANCER: Single-Cell Analysis of the Epigenome and Transcriptome 13. CANCER: Extracellular Vesicles 14. CANCER: Genomic/Functional Screens to Predict Response/Resistance 15. HEART: Regulation of cardiomyocyte contractility 16. HEART: Molecular changes in cardiomyopathies and therapeutic interventions 17. HEART: Molecular mechanisms of mechano-sensing. 18. HEART: Biochemical and structural changes of extracellular matrix during remodelling 19. HEART: 2D and 3D in vitro models of cardiac tissue 20. HEART: Regeneration of the heart 21. REGENERATIVE MEDICINE: Cell reprogramming - change of cell identity 22. REGENERATIVE MEDICINE: Application potential of pluripotent stem cells 23. REGENERATIVE MEDICINE AND VISION: Modeling vision in vitro – retinal organoids and generation of cells for vision therapy 24. REGENERATIVE MEDICINE: Modelling of neural development using pluripotent stem cells 25. REGENERATIVE MEDICINE: 3D cell culture for organoids and organs-on-chip 26. REGENERATIVE MEDICINE: Neuro-regeneration and mini-brains for neurodegenerative diseases in vitro
Literature
  • Scientific articles from the course
  • Presentations from the course
Teaching methods
lectures, class discussion, group projects, and presentations
Assessment methods
Colloquium requirements: active participation on the course, presentation of selected scientific topic/article
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught each semester.
The course is taught: in blocks.
Note related to how often the course is taught: Timetable for autumn 2021 semester: to be specified later.
Teacher's information
https://is.muni.cz/predmet/med/DSAMolM
Marek Mraz, email: marek.mraz@email.cz, ceitec.cz/mrazlab Timetable for spring 2020 semester: Wed 13.5.,Thur 14.5., Fri 15.5., 9:00–15:00, A3/1.17
The course is also listed under the following terms autumn 2021.
  • Enrolment Statistics (spring 2020, recent)
  • Permalink: https://is.muni.cz/course/med/spring2020/DSAMolM