C7410 Structure and Reactivity I

Faculty of Science
Autumn 2001
Extent and Intensity
2/0/0. 3 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Petr Klán, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Petr Klán, Ph.D.
Chemistry Section – Faculty of Science
Prerequisites
organic chemistry, physical chemistry, physics
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 16 fields of study the course is directly associated with, display
Course objectives
This course provides an information about the relationship between the structure of organic compounds and their reactivity. Different ways of chemical activation and the courses of the ractions are discussed.
Syllabus
  • 1. Structure and reactivity relationship. Calibration points in chemistry. Inner parameters of the structure and its deformations. Physical properties caused by (a) geometry of nuclei, (b) electron density and its change. Activation and driving force of the chemical reactions. 2. Thermodynamics and kinetics. Thermochemical calculations. Transition state. Hammond and Curtin-Hammett principle. 3. Substituent effects. LFER. Hammett and Taft equation. QSAR. Hyperconjugation. Isotope effects. 4. Dynamic effects. Conformations. The relationship between the cyclization rate constants and the size of the ring. 5. Aromaticity a antiaromaticity. Aromatic ions and dipoles. Aromaticity of the transition state in the pericyclic reactions. 6. Solvent effects. 7. Acids and bases. 8. Ions and radicals. 9. Electron transfer. Marcus equation. 10. Catalysis. Transition metal catalysis. 11. Photochemistry and photophysics. 12. Spin chemistry. Magnetic field effects. 13. Non-classical activation of chemical reactions. 14. Reactive intermediates. Laser flash spectroscopy.
Literature
  • I. Fleming: Hraniční orbitaly a reakce v organické chemii. SNTL, Praha 1983.
  • O. Exner: Korelační vztahy v organické chemii. SNTL, Praha 1981
  • O. Exner: Struktura a fyzikální vlastnosti organických sloučenin. SNTL, Praha 1985.
  • F. A. Carey, R. J. Sundberg: Advanced Organic Chemistry, 3rd edition, Part A: Structure and Mechanisms. Plenum Press, New York, 1993.
Language of instruction
Czech
Follow-Up Courses
Further Comments
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2001, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2001/C7410