C5420 Analysis of Organic Compounds

Faculty of Science
Autumn 2002
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
doc. RNDr. Pavel Pazdera, CSc. (lecturer)
Guaranteed by
doc. RNDr. Pavel Pazdera, CSc.
Chemistry Section – Faculty of Science
Prerequisites
C2021 Organic Chemistry I && C3022 Organic Chemistry II && C3100 Analytical Chemistry I && C4050 Analytical Chemistry II && C4450 Organic Chemistry III-synth.
Knowledge of the organic and analytic chemistry.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Metodology of organic compound analysis on the base of classical chemical methods and instrumental method applications.
Syllabus
  • Introduction-analysis and identification of organic compouds in organic-chemical research and in technology, comparison with inorganic analysis. Identification of unknowns. Preliminary tests, criterion of purity, detection of organoelemets, elemental analysis, physical and chemical constants, tests of solubility, acidobasical behaviour. IR and NMR characteristics of functional groups. Clasification reactions and determination of functional group: amines (reactions with tosylchloride, nitrous acid, acylchlorides,...). Halogencompounds (reactions with ethanolic solution of silver nitrate, acetonic solution of NaI, ethanolic solution of KOH, test with thiourea and picric acid). Carbonyl compounds (reaction with substituted hydrazine, hydroxylamine, semicarbazide, thiosemikarbazide, sodium hydrogensulfit, iodophorm test. Reaction distinction between aldehydic and ketonic carbonyl group). Phenoles (test with ferric trichloride, bromine water, reaction with acylchlorides, diazonium salt). Alkanoles (test with zinc dichloride solution in hydrogen chlorid, with acylchlorides, periodic acid, chromium trioxide, boric acid and sodium test). Unsaturated bonds between carbon atoms (test with permanganate solution, with bromine solution in tetracarbonyl chloride). Carboxylic acids and their functional derivatives (acidity test, hydroxamic reaction, hydrolytic reaction, biuret test, silver nitrate test). Nitro, nitroso, azo, azoxy, hydrazo compounds and substituted hydrazines (reduction with Zn in ammonium chloride solution, oxidizing with ferrous sulphat, nitrole and pseudonitrole test). Aromatics (reaction with fumming sulphuric acid, bromine watter, benzendiazonium salt). Enthers (reaction with HI, bromine water, ...). Thiole, sulphide, disulphide, oxygen sulphur compounds, (test with permanganate solution, ferrous dihydroxide, Grote's reagent, lead tetraacetate, melting with NaOH and detection of sulphate anion). Completation of results, deducation of probably structure of unknown, procedure for their determination (new compound- analogy with known, detection of functional group by reaction and by spectral methods, describe compound-derivatisation). The preparation of derivatives (micromethods of synthezis). Determination of organic compounds by reaction of functional groups, aplication of instrumental methods. Acidobasical, redox methods, determination of water, gaseous metrical methods, gravimetrical, spectral and electroanalytical methods (coulometry, polarography, ...), adsorption (separation) methods. Sceletal analysis-ozonolysis and similar reaction with consequent hydrogenolysis.
Literature
  • Stránský, Z. a kol. Analýza organických sloučenin, Rektorát UP, Olomouc 1981, 235. str.
  • Shriner, R. L.; Fuson, R. C.; Curtin, D. Y.; Morrill, T. C. The Systematic Identification of Organic Compounds, J. Wiley N. York 1980
  • Mázor, L. Methods of Organic Analysis, The Publishing House of the Hungarian Academy of Sciences, Budapest 1983, ISBN 963-05-2817-7,529 str.
Assessment methods (in Czech)
Přednáška, ústní zkouška.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught once in two years.
Information on the per-term frequency of the course: každý lichý rok.
The course is taught: every week.
General note: Znalost předmetu bude vyžadována u státní závěrečné zkoušky bakalářského i magisterského studijního programu!.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2000, Autumn 2001, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2016, Autumn 2018, Autumn 2019, autumn 2021, Autumn 2023.
  • Enrolment Statistics (Autumn 2002, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2002/C5420