C7870 Biometrics

Faculty of Science
Autumn 2002
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
doc. Ing. Martin Mandl, CSc. (lecturer)
Guaranteed by
doc. Ing. Martin Mandl, CSc.
Chemistry Section – Faculty of Science
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The goals of the lecture are to understand the application of selected statistical methods in the evaluation of data in life sciences. The content of the lecture includes evaluation of experimantal results and methods, errors in data and calculations, significance testing for quantitative and qualitative data, and the use of regression and correlation analysis. The applications are focused especially on (bio)chemistry, microbiology and biotechnology.
Syllabus
  • Application of statistical methods in evaluation of experimental data in (bio)chemistry, biotechnology and microbiology.
  • Statistical characteristics, types of distribution.
  • Confidence intervals, null and aletrnative hypotheses, testing the significance of data.
  • Elimination of systematic errors in parallel data. The use of Poisson distribution for the testing of microbiological data.
  • Testing qualitative data, efficiency determination of bioactive substances.
  • Linear regression, a simple linearity test.
  • Correlation analysis.
  • Linear regression in the calibration of methods and analysis error calculation.
  • Impact of result variability on calculation of the determination limit.
  • Non-linear regression and its application in bioprocess models.
  • Testing linear and non-linear models.
  • Impact of variability of kinetic data on determination of parameters of some processes in biochemistry, physiology and biotechnology.
  • Variability in evaluation of the cell growth and metabolite pruduction.
Literature
  • MICHÁLEK, Jaroslav. Biometrika. 1. vyd. Praha: Státní pedagogické nakladatelství, 1982, 404 s. info
  • ECKSCHLAGER, Karel, Ivan HORSÁK and Zdeněk KODEJŠ. Vyhodnocování analytických výsledků a metod. 1. vyd. Praha: Státní nakladatelství technické literatury, 1980, 223 s. URL info
  • MURRAY, John. Statistics. 1st ed. London: R.C. Solomon, 1996, xi, 369 s. ISBN 0-7195-7088-3. info
  • DORAN, Pauline M. Bioprocess engineering principles. London: Academic Press, 1995, xiv, 439 s. ISBN 0-12-220856-0. info
Assessment methods (in Czech)
Závěrečné hodnocení je písemné, založené na vyhodnocení praktických příkladů za použití materiálů z přednášky.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
Teacher's information
http://orion.chemi.muni.cz/biochem/student.htm
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019.
  • Enrolment Statistics (Autumn 2002, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2002/C7870