C8840 Macrocycle chemistry

Faculty of Science
Autumn 2007 - for the purpose of the accreditation
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Přemysl Lubal, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Přemysl Lubal, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Přemysl Lubal, Ph.D.
Prerequisites (in Czech)
Předpokladem je absolvování základních přednášek z Anorganické chemie I (C1061), Anorganické chemie II (C2062), Organické chemie I (C2021), Organické chemie II (C3022), Analytické chemie I (C3100) a Analytické chemie II (C4050). Je výhodné návštěvovat kurs C8885 Supramolekulární chemie (není podmínkou).
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The lecture demonstrates reactivity and properties of macrocylic compounds and is accompanied by examples taken from literature or from experimental experiences of lecturer. In addition, the potential aplication of macrocyclic complexes in practice is mentioned.
Syllabus
  • 1. Introduction into macrocylic chemistry (nomenclature, natural macrocyles, importance).
  • 2. Types of macrocylic ligands and their complexes, cyclic polyamines and porphyrines, cyclic cyclic polyethers (crowns, polyethers, cryptands, cavitands, calixarens), cyclic ligands with other donor atoms than O or N, polycore a polymer macrocycles, catenans and catenands, macrocyclic sugars, robust macrocycles (sepulchurates), stereoisomerism of macrocycles, "hole-size" concept.
  • 3. Aspects of macrocycle synthesis. Free ligands - non-template synthesis, reaction of ring formation (synthesis under high and low dilution).
  • 4. Complexes - non-template synthesis, template synthesis (influence of physical and chemical conditions on kind and yield of reaction - kinds of template effects), in situ reactions. Derivatization of macrocycles - introduction of functional groups into cyclic skeleton and protection of cyklic skeleton.
  • 5. Chelate and macrocyclic effect - origin and quantification. Experimental techniques suitable for study of reactivity of macrocyklic compounds.
  • 6. Thermodynamic aspect - selectivity for ions. Kinetic aspect - formation and dissociation kinetics.
  • 7. Reactivity of complexes and their redox properties. Stabilisation of less common oxidation states - "metal-centred", "ligand-centred" oxidation and reduction. Substitution reactions in axial site, reaction of coordinated macrocyclic ligand, demetallic reactions and ionic exchange reactions.
  • 8. Macrocyclic systems. Complexation of metal ions (cyclic polyethers, polyamines a polyimins; cryptands, calixarenes, etc.).
  • 9. "Host-guest" chemistry - complexation of organic cations.
  • 10. Complexation of organic anions.
  • 11. Complexation of neutral compounds cyclodextrines.
  • 12. The use of macrocyclic ligands and their complexes in chemistry, biology, medicine - examples.
Literature
  • Constable, Edwin C., Coordination Chemistry of Macrocyclic Compounds, Oxford University Press, Oxford 1999.
  • MARTELL, Arthur E. and Robert D. HANCOCK. Metal complexes in aqueous solutions. New York: Plenum Press, 1996, x, 253 s. ISBN 0-306-45248-0. info
  • Lindoy L.F., The Chemistry of Macrocylic Ligand Complexes, Cambridge University Press, Cambridge 1989.
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Spring 2000, Autumn 2010 - only for the accreditation, Spring 2001, Spring 2002, Autumn 2002, Autumn 2003, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2016, Autumn 2018, Autumn 2020, Autumn 2022, Autumn 2024.