PřF:C3181 Biochemistry I - Course Information
C3181 Biochemistry I
Faculty of ScienceAutumn 2012
- Extent and Intensity
- 2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
- Teacher(s)
- doc. RNDr. Petr Zbořil, CSc. (lecturer)
- Guaranteed by
- prof. RNDr. Zdeněk Glatz, CSc.
Department of Biochemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Vladimír Mikeš, CSc.
Supplier department: Department of Biochemistry – Chemistry Section – Faculty of Science - Timetable
- Mon 13:00–14:50 B11/132
- Prerequisites
- C2021 Organic Chemistry I || C2700 Basic Organic Chemistry
Basic knowledge of organic and general chemistry, biology - Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- Analytical Chemistry (programme PřF, M-CH)
- Analytical Chemistry (programme PřF, N-CH)
- Inorganic Chemistry (programme PřF, M-CH)
- Inorganic Chemistry (programme PřF, N-CH)
- Applied Biochemistry (programme PřF, B-CH)
- Biochemistry (programme PřF, M-CH)
- Biochemistry (programme PřF, N-CH)
- Physical Chemistry (programme PřF, M-CH)
- Physical Chemistry (programme PřF, N-CH)
- Chemistry (programme PřF, M-CH)
- Environmental Chemistry (programme PřF, M-CH)
- Environmental Chemistry (programme PřF, N-CH)
- Macromolecular Chemistry (programme PřF, M-CH)
- Macromolecular Chemistry (programme PřF, N-CH)
- Organic Chemistry (programme PřF, M-CH)
- Organic Chemistry (programme PřF, N-CH)
- Upper Secondary School Teacher Training in Chemistry (programme PřF, M-CH)
- Course objectives
- The course covers the basic fields of biochemistry from the chemical point of view. Most important properties and structure of natural substances(aminoacids and proteins, carbohydrates, lipids) are described here. The general description of chemical reactions in the cell includes enzymes and coenzymes, their properties and structure, active site, thermodynamics, enzyme kinetics, inhibition, allostery and regulation of enzyme acitivity. Special chapters describe most important metabolism of carbohydrates and lipids with emphasis on energetic features of metabolism.
The goal of this course in to equip students with the basic knowledge about chemical principles of metabolism. - Syllabus
- 1. Aminoacids, properties, determination, chromatography 2. Peptides, peptide bond, primary, secondary, terciary, quaternary structure 3. Non-repetitive structures, colagene, hydropathy, properties of proteins 4. Glycides, properties, reactions, anomers, semiacetals, anomers. conformation 5. Glycosides, oligosaccharides, polysaccharides (starch, glycoge, chitin), heteropolysaccharides. 6. Lipids, acylglycerols, phospholipids, plasmalogens, sphingolipids, steroids 7. Nucleic acids, nucleosides, nucleotides, primary structure 8. DNA, RNA, double-helix, superhelix, denaturation, hybride structure, methods for determination of primary structure 9. Thermodynamics in biochemistry, macroergic bond, reaction kinetics, enzymes, their active site, prosthetic groups, coenzymes, mechanism of enzyme catalysis 10. Coenzymes and vitamins, nicotinamide and NAD, flavins, ATP. AMO, cAMO, biotin, thiamin, coenzyme A, lipoic acid, folic acid 11. Pyridoxalphosphate, B12, metaloporphyrins, iron-sulfur proteins, vitamin C, lipophilic vitamins 12. Michaelis-Menten equation, Km, VL, turnover number, enzyme activity 13. Anabolims, catabolism, their regulation, anaerobic glycolysis 14. Gluconeogenesis, synthesis of PEP, glycogenolysis, synthesis of glycogen, Cori cycle
- Literature
- Vodážka - Biochemie
- Voet, Voetová - Biochemie; Zubay, Parson, Vance - Principles of Biochemistry
- Mikeš - Základní pojmy z biochemie II
- Teaching methods
- Theoretical lecture.
- Assessment methods
- Lecture 2 hr. Written examination.
- Language of instruction
- Czech
- Follow-Up Courses
- Further comments (probably available only in Czech)
- Study Materials
The course can also be completed outside the examination period.
The course is taught annually. - Listed among pre-requisites of other courses
- C1220 Technologie buněčných kultur
C3181 || C3580 || C5720 - C1230 Technologie buněčných k. -cv
C3181 || C3580 || C5720 - C3180 Biochemistry I - seminar
NOW(C3181) - C3190 Biochemistry I - seminar
NOW(C3181) - C4182 Biochemistry II
C3181 - C4200 Biochemistry II - seminar
C3181 && NOW(C4182) - C4220 Biochemistry - laboratory course
C3181 && (C4221||C1100) - C4230 Biochemistry - laboratory course
C3181 && (C4221||C1100) - C4830 Instrumental Methods in Biochemistry
C3181 || C3580
- C1220 Technologie buněčných kultur
- Enrolment Statistics (Autumn 2012, recent)
- Permalink: https://is.muni.cz/course/sci/autumn2012/C3181