C8790 Organic chemistry in pharmacy

Faculty of Science
Spring 2016
Extent and Intensity
2/0/0. 2 credit(s) (plus 1 credit for an exam). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
RNDr. Miloslav Smrž, CSc. (lecturer), prof. RNDr. Milan Potáček, CSc. (deputy)
Guaranteed by
prof. RNDr. Milan Potáček, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Milan Potáček, CSc.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Timetable
Fri 8:00–9:50 B11/235
Prerequisites
C2021 Organic Chemistry I && ( C3022 Organic Chemistry II/1 || C3050 Organic Chemistry II )
General knowledge of chemistry, mainly organic chemistry
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is an introduction into the system of drug research and development highlighting the role of organic chemists in this system. Students will be acquainted with a modern approach to solution of various problems of drug R&D and transfer its results into production, in particular by way of examples of anticancer medicines.
Syllabus
  • Importance of chemotherapeutics, brief history of pharmacotherapy, drug policy. Introduction to pharmacology: basic terms, drug targets, pharmacodynamics and pharmacokinetics. Organization of drug research and development. Drug discovery. Combinatorial synthesis and high throughput screening. Drug design. Lead structure and pharmacophore, stereochemical aspects, quantitative structure-activity relationships. Drug development. Polymorphism. Manufacturing processes for active pharmaceutical ingredients. Good manufacturing practice. Process validation and documentation. Drug delivery. Drug forms and bioavailability. Active ingredients and excipients. Pharmaceutical technology. Drug stability, specification and procedures for quality control. Preclinical testing, clinical trials, drug registration and marketing approval. Intellectual property protection. Patents, patenting, search for patent documents. International anatomical-therapeutical-chemical drug classification. Drug information resources. Anticancers as example of an ATC drug class. Causes of cancer, cancer chemotherapy, mechanism of anticancer drug action. Conventional and targeted anticancer medicines. Perspectives of cancer therapy. Examples of generic drug development An excursion to a pharmaceutical company – if possible
Literature
    recommended literature
  • HAMPL, František, Stanislav RÁDL and Jaroslav PALEČEK. Farmakochemie. 2. rozš. vyd. Praha: Vydavatelství VŠCHT, 2007, 448 s. ISBN 9788070806395. info
Teaching methods
lectures
Assessment methods
The course consists of several lectures and is closed by a written examination. Students are challenged with 12 questions reflecting various aspects of pharmacochemistry. Each answer is scored, maximum score is 10 points. Total number of points must be at least 46 to pass the examination.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2000, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023.
  • Enrolment Statistics (Spring 2016, recent)
  • Permalink: https://is.muni.cz/course/sci/spring2016/C8790