C3900 Molecular mechanisms of cell aging

Faculty of Science
spring 2018
Extent and Intensity
1/0/0. 1 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium), z (credit).
Teacher(s)
doc. Mgr. Petra Procházková Schrumpfová, Ph.D. (lecturer)
Mgr. Šárka Schořová, Ph.D. (alternate examiner)
Guaranteed by
prof. RNDr. Jiří Fajkus, CSc.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Prerequisites
Students should have elementary knowledge of molecular or cellular biology.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of this course, students will be able: understand and explain the processes of cell aging, including genomic and epigenetic stability, changes of metabolism and protein homeostasis or dependence organisms on energy sources; use information about methods and procedures used in various laboratories for analysis of the process of cellular aging; based on acquired knowledge to derive and design your own methodology to characterize the aging of the organism; interpret the results and methods used in the study of cellular aging;
Syllabus
  • theories of ageing
  • ageing and cancer
  • stochastic nature of ageing process
  • programmed theories of ageing
  • damage-based theories of ageing
  • progeroid syndromes
  • protein oxidation in ageing
  • nuclear architecture in ageing
  • telomere attrition
  • mitochondrial dysfunction
  • cellular senescence
  • epigenetic alterations
  • loss of proteostasis
  • caloric restriction
  • stem cell exhaustion
  • altered intercellular communication
  • the influence of the microbiome to ageing
  • ageing in different organisms
  • anti-ageing medicine
Literature
Teaching methods
lectures, class discussion, presentations by professionals in the ageing field,
Assessment methods
for passing the colloquium the written test on 5-issues is needed, for passing the examination the written test is needed, the test consists of 20 questions, 50% of correct answers is needed to pass
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: in blocks.
General note: Předmět může být vyučován v češtině i angličtině.
The course is also listed under the following terms Spring 2015, Spring 2016, Spring 2017, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (spring 2018, recent)
  • Permalink: https://is.muni.cz/course/sci/spring2018/C3900