A picture containing text, clock, dark Description automatically generated A picture containing ceiling, building Description automatically generated Text Description automatically generated Scientific Board of CEITEC MU Meeting 10th November 2022 A picture containing text, clock, dark Description automatically generated Overview of 2022 -Jiří Nantl A picture containing text, clock, dark Description automatically generated Nature Index (NI) 2021 publications Czech institutions Count Number of results in NI Share Proportion of Local Authors According to the NI Czech Academy of Sciences 470 91.36 Charles University 285 31.12 Masaryk University 92 16.04 Palacky University 113 15.49 University of Chemistry and Technology, Prague 32 10.15 Brno University of Technology 70 5.23 Czech Technical University in Prague 100 5.18 University of South Bohemia, Czech Republic 34 5.16 Mendel University in Brno, Czech Republic 61 4.64 Silesian University in Opava, Czech Republic 14 4.21 CEITEC MU 23 3.90 A picture containing text, clock, dark Description automatically generated Publications 2022: Highlights -Hluchy, M.; Gajduskova, P.; Ruiz de los Mozos, I.; Rajecky, M.; Kluge, M.; Berger, B.-T.; Slaba, Z.; Potesil, D.; Weiss, E.; Ule, J.; Zdrahal, Z.; Knapp, S.; Paruch, K.; Friedel, C. C.; Blazek, D. CDK11 Regulates Pre-MRNA Splicing by Phosphorylation OfSF3B1. Nature 2022, 609 (7928), 829-+. https://doi.org/10.1038/s41586-022-05204-z. - -Cairo, A.; Vargova, A.; Shukla, N.; Capitao, C.; Mikulkova, P.; Valuchova, S.; Pecinkova, J.; Bulankova, P.; Riha, K. Meiotic Exit in Arabidopsis Is Driven by P-Body–Mediated Inhibition of Translation. Science 2022, 377 (6606), 629–634. https://doi.org/10.1126/science.abo0904. - -Zapletal, D.; Taborska, E.; Pasulka, J.; Malik, R.; Kubicek, K.; Zanova, M.; Much, C.; Sebesta, M.; Buccheri, V.; Horvat, F.; Jenickova, I.; Prochazkova, M.; Prochazka, J.; Pinkas, M.; Novacek, J.; Joseph, D. F.; Sedlacek, R.; Bernecky, C.; O’Carroll, D.; Stefl, R.; Svoboda, P. Structural and Functional Basis of Mammalian MicroRNA Biogenesis by Dicer. Molecular Cell 2022, 82 (21), 4064-4079.e13. https://doi.org/10.1016/j.molcel.2022.10.010. - - - Image result for nature journal logo Molecular Cell (@MolecularCell) / Twitter A picture containing text, clock, dark Description automatically generated Research Field - Oriented Analysis Quality of CEITEC MU Publications in Subject Categories: Percentage of Publications in Q1 in 2021 Toto je zajímavější graf, protože pracuje s kvalitou dle oborů a navíc s publikacemi, kde máme korespondenčního autora. A picture containing text, clock, dark Description automatically generated National evaluation system „M17+“ Module 1: Quality of Selected Results Evaluations of nebiblio results (summary of evaluation H17 – H21) Evaluations of biblio results (evaluation H19 - H21) A picture containing text, clock, dark Description automatically generated Grants -The grant strategy is based on individual research grants. -CEITEC MU has a higher than national average success rate in all national grant schemes. -CEITEC has ambition to receive institutional grants that support further development initiatives at a larger scale: Horizon Europe – Teaming and OP JAK. - Success rate in % of projects submitted and awarded Percentage Success Rate – Submitted / Awarded Projects 2018 2019 2020 2021 National 43% 23,90% 31,80% 32,70% International 12,80% 32% 30,80% 30,30% A picture containing text, clock, dark Description automatically generated CEITEC wants to strengthen Brno´s position on the global electron microscopy map A picture containing text, clock, dark Description automatically generated TEAMING proposal submitted -CORMIC - Bridging Academia and Industry in Correlative Microscopy -Partners: CEITEC MU, CEITEC BUT, ISI CAS, EMBL, TU-Wien -Impact -life science research leveraging correlative microscopy approaches -microscopy technology development at the interface of life and material sciences -education of experts in microscopy -technology transfer and entrepreneurial spirit -Submission 2nd round: 8th September 2022 -Evaluation result expected: December 2022 -Competition: -116 proposals to 1st round evaluation (9 from the Czech Republic submitted) -32 projects were invited for 2nd round, max. 10 projects will be awarded - - - - A picture containing text, clock, dark Description automatically generated Selected Grant Achievements 2022 -P. Plevka: ERC Consolidator – EU - Phage infection of bacterial biofilm (1 992 976 EUR) -J. Hritz: Excellence Hubs – Horizon Europe - Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe (1 684 319 EUR) -I. Rektor: Pathfinder - EIC - First Closed-loop non-Invasive Seizure Prevention System (356 500 EUR) -A. Ghosh (RG L. Trantírek): MSCA-PF – Horizon Europe - In vitro and In-cell characterization of Quadruplex-duplex hybrids: conformation, folding, ligand binding and implications for in-cell NMR based assays (166 279 EUR) -P. Plevka: EXCELES – National Recovery Plan (MEYS) – National Institute of Virology and Bacteriology (7 mil. EUR) -O. Slabý: EXCELES – National Recovery Plan (MEYS) - National Institute for Cancer research (2,4 mil. EUR) V roce 2021 nebylo otevřených moc výzev. A picture containing text, clock, dark Description automatically generated TWO GA CR EXPRO for CEITEC MU - -K. Říha: GAČR EXPRO - Biomolecular condensates in plant germline differentiation (49 730 000 Kč) -D. Blažek: GAČR EXPRO - Identification and characterization of a new pathway regulating pre-mRNA splicing (49 981 000 Kč) - - GA CR Project Proposals 2023 (total/awarded) CEITEC ECON PHARM ARTS FI SPORT FSS MED PED LAW SCI ICS TOTAL EXPRO 6/2 0 0 3/0 0 1/0 3/1 0 0 0 2/0 0 15/3 JUNIOR STAR 2/0 3/0 1/0 3/1 1/0 2/0 2/0 0 0 0 4/1 1/0 19/2 TOTAL SUM 8/2 3/0 1/0 6/1 1/0 3/0 5/1 0 0 0 6/1 1/0 34/5 V roce 2021 nebylo otevřených moc výzev. A picture containing text, clock, dark Description automatically generated GA CR - - - - EXPRO 2020 2021 2022* 2023 Submitted Projects GA CR- (MU*) 133 (24) 123 (24) - ? (15) Awarded Projects GA CR- (MU*) 22 (3) 16 (6) - 10 (3) Success Rate in % - CR TOTAL (MU*) 16,5 (12,5) 13 (25) - ? (20) JUNIOR STAR 2021 2022 2023 Submitted Projects GA CR- (MU*) 355 (28) 315 (28) ? (19) Awarded Projects GA CR- (MU*) 30 (2) 16 (3) 23 (2) Success Rate in %- CR TOTAL (MU*) 8,4 (7,1) 5 (10,7) ? (10,5) V roce 2021 nebylo otevřených moc výzev. A picture containing text, clock, dark Description automatically generated CEITEC PhD School -Currently 79 students in total -Gender balance: 41F / 38M -38 international students from 17 countries -Graduates 7 (2021 – 3 graduates) -Abandoned studies: 1 - -Life Sciences Programme (Sci) -newly re-accredited since the academic year 2021/2022 -students 75 / international 52 - -Molecular Medicine (Med) -first international students (3) admitted in 2021 -students 6 / international 3 - - - - - - Community events Scientific events Public events Retreats Group leaders Postdocs PhDs Career development events Events as a building blocks of community development A picture containing text, clock, dark Description automatically generated -EMBO Course Light sheet microscopy -Leadership and Mentoring Skills for Research Group Leaders and Core Facility Heads by Saša Kočevar, Thomas Frick -SIY Adaptive Resilience Series – Mental Health and Stress Management for postdocs -How to be an Active Bystander by Magali Berger Churchill -Presentation skills for Research Group and Core Facility Heads by Dr Samuel Lagier -Communication in media by Czech Press Office -Culture Differences in Communication by Eva Gaborikova - 15 The Institute of Physics has been awarded the HR Excellence in Research Award | FZU Selected training A picture containing text, clock, dark Description automatically generated A person holding a trophy Description automatically generated with medium confidence Awards for CEITEC researchers in 2022 -Rector's Award for Extraordinary International Grant Competition Results – Robert Vácha -Rector's Award for Outstanding Research Results Achieved by Young Scientists under 35 – Zdeněk Farka -Rector's Award for innovations in teaching – Nikola Kostlánová -NEURON Prize for promising scientists – Gabriel Demo -Purkyne Foundation Award for best publication – Václav Šeda -New EMBO member – Šárka Pospíšilová A picture containing text, clock, dark Description automatically generated TECHNOLOGY TRANSFER: Successful Cases 2022 -Licence: -licence agreement with AI|ffinity to use softwares: -4D CHAINS: 30kCZK/year + 8% royalties -4D GRAPHS: 40kCZK (one-time fee) + 8% royalties -Service Agreements: -ECM DIAGNOSTICS (RG Ondřej Slabý, 5kUSD) -BioVendor (CF Genomics, 36kCZK) -Collaboration Agreement: -AppsDevTeam (CF Bioinformatics/RG Panagiotis Alexiou) -Amendment to Collaboration Agreement (contract extension): -Thermo Fisher Scientific (CF CryoEM) - A picture containing text, clock, dark Description automatically generated Applied Results 2020-2022* Scientific Board 2022 Legend: P – Patent (granted), Pa – Patent application, F – Utility Model, G – Prototype, N – Methodics, R – Software, Z – Pilot Plant *period 1.1.2020 – 4.11.2022 A picture containing text, clock, dark Description automatically generated Dissolution of Panagiotis Alexiou Research Group - A picture containing text, clock, dark Description automatically generated Congratulation to Panagiotis Alexiou who have been offered and accepted an ERA Chair position to build up a Bioinformatics research program at the University of Malta. A picture containing text, clock, dark Description automatically generated ISAB 2022 - A picture containing text, clock, dark Description automatically generated ISAB 2022 Dorothea Bartels Biology | Special Issue : Abiotic Stress Tolerance in Cereals Claudia Köhler NWO | Gaia Pigino Gaia Pigino Obsah obrázku exteriér, rostlina, zahrada Popis byl vytvořen automaticky Obsah obrázku osoba, zeď, muž, interiér Popis byl vytvořen automaticky Witold Filipowicz Michal Hocek Philipp Selenko Johannes Zuber Christoph M. Michel Dirk Inzé Viktor K. Jirsa Michael Hothorn Scientists | Clore Institute Eric Lecuyer A picture containing text, clock, dark Description automatically generated A group of people posing for a photo Description automatically generated Evaluation of research excellence 2022 A picture containing text, clock, dark Description automatically generated A person giving a presentation to an audience Description automatically generated with medium confidence -Evaluation of research excellence 2022 - -Mini-conference: 17. 10. 2022 -Interviews: 18. 10. 2022 -Meeting with CEITEC MU management: 19. 10. 2022 -Final report expected in November A picture containing text, clock, dark Description automatically generated CEITEC MU Core Facilities -Pavel Plevka A picture containing text, clock, dark Description automatically generated p1 State of the art research facilities are the key to high quality research. The CEITEC core facilities are spread on more than 25000 square meters and offer the research community access to cutting edge equipment. All CEITEC core facilities are available to external users (academia and companies). Core facilities are TECHNOLOGICAL UNITs equipped with the FIRST-RATE EQUIPMENT available to scientists from a range of fields. The aim is to provide scientists with INFRASTRUCTURE allowing for them to effectively carry out scientific projects without the necessity to buy their own INSTRUMENTS. A picture containing text, clock, dark Description automatically generated A group of people posing for a photo Description automatically generated -Chair: Pavel Plevka, CEITEC MU Deputy Director for Research Infrastructure -Members: -Karel Říha, CEITEC MU Deputy Director for Science -Martin Blackledge, Institut de Biologie Structurale -Fernando Peláez, CNIO -Jakub Jež, Vienna BioCenter Core Facilities (VBCF) -Claus Lamm, University of Vienna -Gábor Csúcs, ETH Zürich -Secretary: Kateřina Hošková, CEITEC MU Core Facilities and Research Infrastructure Specialist -On-site support: Pavla Pospíšilová, CEITEC MU project administrator 2022 CF Evaluation A picture containing text, clock, dark Description automatically generated Acknowledgments to CFs A picture containing text, clock, dark Description automatically generated Number of users A picture containing text, clock, dark Description automatically generated Internal vs. external users A picture containing text, clock, dark Description automatically generated CF day 22. 11. 2022 -Event webpage: bit.ly/CFDayMeeting2022 -Hybrid: ZOOM / E35-145 - -Content: -CF overview – services, trainings, user rules -New instrumentation -CF data policy A picture containing text, clock, dark Description automatically generated CF: Cellular Imaging Core Facility CF: Plant Sciences Core Facility CF: Genomics Core Facility A picture containing text, clock, dark Description automatically generated CF: Genomics Core Facility CF: Nanobiotechnology Core Facility CF: Bioinformatics Core Facility A picture containing text, clock, dark Description automatically generated CF: Cryo-Electron Microscopy and Tomography Core Facility CF: Cellular Imaging Core Facility CF: Proteomics Core Facility A picture containing text, clock, dark Description automatically generated Long term vision + strategy -Anticipate developments in research methods: - Promote integrative services – analyses of samples by multiple CFs. - Reflect in future purchases of instruments. -Expand support provided to users in data analyses. -Strategy to handle increased amounts of recorded data & open data – BioData CF. -Strategy to maintain / discontinue depreciated but useful instruments (risk management). -HR strategy of CF focused on staff retainment and development/training. -Implementation of electronic tools for data management and communication with users. A picture containing text, clock, dark Description automatically generated CF: Cryo-Electron Microscopy and Tomography Core Facility CF: Josef Dadok National NMR Centre Mgr. Jiří Nováček, Ph.D. doc. RNDr. Radovan Fiala, CSc. Radovan Fiala CF: Proteomics Core Facility Prof. Zbyněk Zdráhal Zbyněk Zdráhal CF: X-ray Diffraction and Bio-SAXS Core Facility Jaromír Marek, Ph.D. Jaromír Marek CF: Biomolecular Interactions and Crystallization Core Facility Mgr. Josef Houser, Ph.D. Josef Houser CF: Nanobiotechnology Core Facility Jan Přibyl, Ph.D. CF: Multimodal and Functional Imaging Laboratory Ing. Michal Mikl, Ph.D. CF: Genomics Core Facility Boris Tichý, Ph.D. CF: Cellular Imaging Core Facility Mgr. Milan Ešner, Ph.D. CF: Plant Sciences Core Facility Mgr. Markéta Pernisová, Ph.D. CF: Bioinformatics Core Facility Panagiotis Alexiou, Ph.D. CF: Biological Data Management and Analysis Core Facility Radka Svobodová, Ph.D. Jiří Nováček Jan Přibyl Michal Mikl Markéta Pernisová Boris Tichý Milan Ešner Panagiotis Alexiou Radka Svobodová A picture containing text, clock, dark Description automatically generated CF administration team Kateřina Hošková Core Facilities and Research Infrastructure Specialist Radka Kejmarová Administrator - monitoring, reporting, internal invoicing Pavla Pospíšílova Administrator - external invoicing Daria Kuchařová Project manager - Horizon projects Tomáš Bártek Booking system administration, technical support Mgr. Kateřina Hošková Mgr. Pavla Pospíšilová Mgr. Radka Kejmarová Mgr. Tomáš Bártek Ing. Daria Kuchařová A picture containing text, clock, dark Description automatically generated •RI support is major source of financing of CEITEC CFs. • •Current project scheme ends 12/2022. • •New projects for the period 2023-2026 are expected to be reduced to 75-50% of the requested budget • •CFs participate in 15 national and 8 international projects •In 2020 – 2021, almost 300 million CZK / 11.3 million EUR was invested in new technologies and instrument upgrades thanks to OP VVV projects Operation costs 3.3 million EUR in 2021 A picture containing text, clock, dark Description automatically generated Thank you for your attention -In the case of questions, contact us at: core.facilities@ceitec.muni.cz -Follow the webpage: https://www.ceitec.eu/core-facilities/ - - CEITEC @CEITEC_Brno A picture containing text, clock, dark Description automatically generated General debate -