Sustainable regional development (case study) Annotation: The implementation of the concept of sustainable development can be effectively supported by the application of the “think globally, act locally” approach. In this context, the theoretical and methodological basis of the dissertation thesis will be elaborated on the basis of an analysis of available scientific literature and own knowledge, which will be subsequently developed in detail including a case study proposal. Aim: The thesis aims to analyse the existing experience with the application of the above mentioned environmental approach, and on the basis of an adequately structured synthesis it is purposefully applied to a concrete case study of sustainable development of a selected region of the Czech Republic.