3 CONTENTS FOREWORD 5 1 Theoretical part 6 1.1 Oncological diseases epidemiology 6 1.1.1 Malignant neoplasm of the colon and rectum 7 1.1.2 Malignant neoplasm of the lungs 8 1.1.3 Malignant neoplasm of the breast 8 1.1.4 The malignant neoplasm of the prostate 10 1.1.5 Other common tumours 11 1.2 Consequences and late complications of oncology treatment 11 1.2.1 Cardiotoxicity 11 1.2.2 Haematological toxicity 12 1.2.3 Nausea and vomiting after anticancer treatment 12 1.2.4 Mucositis 13 1.2.5 Neurotoxic manifestations 13 1.2.6 Pulmonary toxicity 13 1.2.7 Hepatotoxicity 14 1.2.8 Nephrotoxicity 14 1.2.9 Skin toxicity 14 1.2.10 Secondary tumours 14 1.3 Biological and physiological changes in the body during tumorous disease and their long-term impact 14 1.4 The effect of physical activity on the human body 25 1.5 Movement intervention in cancer patients 37 1.5.1 Recommendations for PA 37 1.5.2 Pre-rehabilitation movement intervention 45 1.5.3 Physical intervention during chemotherapy 48 1.5.4 Physical intervention after treatment in remission, survived 49 1.5.5 Exercise in patients with advanced and metastatic disease 50 1.5.6 Conclusion – proposal of physical programme 50 1.5.7 Contraindication for exercise 52 1.5.8 Risks linked with exercise 52 1.6 Physical fitness monitoring 53 1.6.1 Performance examination 53 1.6.2 Body composition 56 4 1.6.3 Strength 58 1.6.4 Autonomic nervous system (ANS) 59 1.6.5 Quality of life 60 2 Research results 63 2.1 Physical intervention in haemato-oncology patients in remission 63 2.1.1 Research aim 63 2.1.2 Methodology 63 2.1.3 Research methods 64 2.1.4 Research design 65 2.1.5 Physical intervention 66 2.1.6 Statistical data processing 68 2.1.7 Results 68 2.1.8 Discussion 85 2.1.9 Conclusion 87 CONCLUSION 88 SUMMARY 89 REFERENCES 90 INDEX 113