Original slides-Circulation lecture
CIRCULATION - doted system -parallel circuits permit varialinns in regional BV ■ „,,, jiI,I■„ vryi-111■Jnci»IaJ " il himl chanpes in UP
Antoregulatioti H: Starling p. frequency e
Vessels: Myotonic Metabolic Humoral (NO, Endothel i Prostaglandins
Humoral
Adrenalin Nor ad renal in
Angiotensin II
|S J* CONSULT
BIimmI pressure \"arialion Ileal hy he a Systolic Diasl oiic
a.-|H m!i »I oo peripher and cardiac interval Pulse
dependent un stroke vi: long lasting change or Mean
I resist aqee
0   U04OIUI5II ■«'HUI
I mniiit.....m -
Homeort^ of BP
< rabbit n. tfa ui      i ■
# tont? aa. (sy)
VOLl-MOKFCm t.*m pnuurt1 - atrial
rec. I
Acilv durin« atrial syst r. of Ruinhridgc #ILR during* VR
« m
Acllv ill iln- end of dl;i-s(olr
RECEPTORS
CHEMORECEPTORS At#p02.*pCOJT*pII ♦ HR+ vasoconslr.
1. i.i VKNTR1CIJES veratrtdin, nltoun Refold-Jariwrli Ischemic (Ml)*UH M*ou pain, \asoconstr. and*!IK(MI>
"i i\ I ■.(«■-:■ i ■- irt gtwirtrffi i'.iin. ,-rftfmfltlous. Oc-utncard. eeflvs, > l>lec*tlvt sclent
*HK,*ADH(llcnrj-(;outr rrfles^+*3ecn:tii.i|i of ANFand BF In Wdncy
antidiuretic liormon atrial iiatrilireuc homBII
A change of duration of pulse interval (in msi due to a change «r blond pressure by I inin11«
Barorcflcv sensitivity BUS ...... ms/mmHg
Bolus injections of vasoactive drugs
MOOr
120
SystoBc pressure (mmHg)
lTIG, 5.4. Comparison or R-R interval responses of one subject to intra Mus injections of phenylephrine and nitroglycerine. Adapted with pcrmissio I'kkeringrla/. 1972c).
OJtTEX
inrormLiMis
CEREBELLUM Adaptation of HK during movements
MED. OUL B.VKOREFLKX
t Illhlliitl.m nl Ionic illsd ol vasomotor nn 1. \cnv»lril paensvmp. ncl ambigumlHK
4. th£rmor.
UEMIJA
cut
BF40bubHe
Biofeedback
\.Limbic system
- agressive -#BP,*HR •„dead" #B1\ *IIR
collaps 2. tin nl     I ii >n of BRS Direct stim p( 'Oj — VASOMOTOR TONUS
♦ intracran. press. -»#BP+ reflex, bradycardia = Cubing reflex
CHEMOR£FL£X
I vessels heart
Inervation of Blood Vessels
• Sympathetic nerves - plexus on adventitia, current spreads between cells by gap junctions, tonic vasoconstrictor) activity (sympathectomy -dilation); NA ... + neuropeptid V (constr)
• Sympathetic cholinergic vasodilator system muscle -animals
• Cholinergic inervation in vessels of heart, lungs, kidneys, uterus; + VIP (dil)
• Sensoij nerves   (antidromic reflex - dil), SubstP (skin) CGRP
Cardiac Inervation
* Vagus -ACh - - chronotropic, prevalence at rest = „ vagal tone", - dromotropic, atrial myocardial cells neg. - inotropic via inhibition ofsymp.
• Sympathetic nerves - NA + chronotropic, +dromotropic, inhibition of vagal stim. (by cotransmitter neurop. Y),
+ inotropic, + hatlimotropic
Blockade of vagus - UK 150-1811 bpm Blockade ol both - MR 100 bpm