OLE MAALOEESVEJ 5
DK-2200 COPENHAGEN N.
DENMARK
TEL +45 35 32 21 20
FAX +45 35 32 21 28
mlisby@bio.ku.dk
www.bio.ku.dk
22 SEPTEMBER 2012
To Prof. Petr Dvorak, Ph.D.
Head of Department of Biology
Faculty of Medicine & Vice-rector for Research
Masaryk University
Brno, Czech Republic
Evaluation of Habilitation Thesis of Lumir Krejci.
I hereby recommend the Habilitation Thesis of Lumir Krejci with the title
”Homologous recombination and its quality control” for defense.
My evaluation in brief:
a) The theme of the Habilitation Thesis is highly relevant with many implications
for human genetic diseases and fertility issues.
b) The experimental methods are described in great detail and are state-ofthe-art
in the field.
c) Genome dynamics and evolution is highly influenced by the process of
homologous recombination, which is tightly regulated and involves in
the range of 50-100 proteins and post-translational protein modifications.
Reconstitution of the individual biochemical steps of homologous
recombination is therefore a tremendous challenged, which has nevertheless
been accomplished by the research group headed by Lumir
Krejci. Only in the light of biochemical studies can the available genetic
and cell biological data in the field be interpreted properly. Lumir
Krejci’s work is therefore essential to the progress of science in the
field of DNA repair and genome integrity.
d) I recommend the submitted paper for defense as a Habilitation Thesis.
Please see the attached evaluation report for specific comments on the Habilitation
Thesis.
Yours sincerely
Michael Lisby
Associate Professor, Ph.D.