1. Eliska Signalling pathways of estrogens and retinoids, as part of endocrine system, [SB1] are included in [INS: the :INS] regulation of many crucial processes controlling functions of immunity, metabolism, development and behavior. Disruption of these signalling systems [SB2] can lead to serious impacts on living organisms. [INS: The :INS] [DEL: P :DEL] [INS: p :INS] resence of anthropogenic endocrine disruptors in the aquatic environment has been intensively studied, but endocrine disruptive compounds can be also of natural origin[SB3] . The aim of this study was [SB4] to investigate if cyanobacteria produce estrogen-like and retinoid-like [SB5] compounds. Various [SB6] cyanobacterial species were cultivated and their intra- and extra-cellular metabolites were studied. Potencies of the metabolites to activate estrogen and/or retinoid receptors were examined by reporter gene cellular models. The activities of metabolites were compared to the effects of well-described ligands of estrogen and retinoid receptors,[INS: that is, :INS] 17b-estradiol and all-trans retinoic acid, respectively. [INS: The :INS] [DEL: O :DEL] [INS: o :INS] bserved effects of intracellular cyanobacterial metabolites reached up to tens of ng estrogen equivalent and thousands of[SB7] retinoid equivalent per g of dry matter of biomass. Extracellular metabolites showed only the retinoid-like potency, retinoid equivalents were up to thousands ng/L of cultivation volume. Th[INS: is :INS] [DEL: e :DEL] study documents that [SB8] some cyanobacteria are producers of metabolites with potency to effect estrogen and retinoid signaling systems in vitro. The levels of the observed effects could cause effects to living organisms[SB9] in water environments and should be considered in a risk assessment[INS: , :INS] especially during an occurrence of water blooms.[INS: :INS] 2. Marek (Re-thinking of ex ante impact assessment of low emission zones in EU) Low emission zones (LEZs) are the most implemented transport measures [INS: in Europe :INS] to decrease [INS: the :INS] level of air pollution in urban environments[DEL: in Europe :DEL] . However, [DEL: the :DEL] evidence of [INS: the :INS] benefits from their implementation is still not observed. The aim of the paper is to review and critically analyse modeling methods used for ex ante impact assessments of LEZs conducted in the past[DEL: times :DEL] , when these assessment studies were used as justification for[INS: their :INS] implementation[DEL: of LEZs :DEL] . The review analyses 12 studies from Germany, France, UK, Sweden, Italy and Denmark [DEL: and :DEL] [INS: whereby :INS] the structure, modeling methods and outcomes of the studies are compared to each other. The analysis discerns [INS: the :INS] systematic[DEL: al :DEL] overestimation of positive impacts which [DEL: concluded into :DEL] [INS: resulted in an :INS] overestimation of [INS: the :INS] benefits of LEZs, particularly due to inappropriate use of modeling methods. Since the European Commission and national governments are willing to support rapid implementation of LEZs, the paper claims for [SB10] serious re-thinking of modeling methods commonly used in ex ante impact assessment of LEZs.[INS: :INS] 3. Anna Sustained over-activation of the Receptor for Advanced Glycation End-products (RAGE) in diabetes is considered [INS: to be :INS] one of the pathways [DEL: involved in :DEL] [INS: leading to :INS] hyperglycemia induced damage and chronic inflammation. One of the possible mechanisms responsible for sustained RAGE activation might be promoter DNA methylation induced by high ambient glucose. In a pilot study[INS: , :INS] we investigated RAGE promoter methylation in normo- and hyperglycemia in vitro (i.e. cell lines corresponding with typical diabetic complications sites) and in vivo (i.e. in non-diabetic vs. poorly controlled diabetics). Embryonic kidney and endothelial cell lines were cultivated in 5 vs. 25 mM/L glucose in culture medium[INS: . :INS] [DEL: and p :DEL] [INS: P :INS] eripheral blood was drawn and mononuclear cells were separated from patients suffering from type 2 diabetes with established diabetic kidney disease and healthy counterparts. Although increased expression of RAGE was found in [INS: the :INS] embryonic kidney cell line and in[INS: the :INS] in vivo experiment[INS: , :INS] no associations between RAGE promoter methylation and its expression were found.[INS: :INS] 4. Vít This study is the first attempt [INS: of its kind (?) :INS] to examine the validity of the Expressions of Spirituality Inventory (ESI) for use in the Czech context. Data were obtained via [INS: an :INS] online survey from 222 emerging adults (18-25 years; 82% women), with a background in helping professions[SB11] . Structural equation modelling revealed reasonably good support for [INS: the :INS] structural validity of the ESI factor model. In addition, all of the subscales showed relatively high values of internal consistency. However, problems with [INS: the :INS] measurement [INS: of :INS] non-invariance [DEL: with :DEL] [INS: in :INS] the sample were present as some items correlated with different dimensions[INS: , contrary to expectations. :INS] [DEL: than expected. :DEL] These findings are consistent with cross-cultural research on ESI showing that the ESI has structural but not measurement invariance at the item and dimension level. Overall, [INS: the :INS] results of this study [DEL: give :DEL] [INS: provide :INS] support for factorial validity and internal consistency of the ESI in the Czech context.[INS: :INS] 5. Monika Introduction: In ordinary life[SB12] the handwriting is not using so often than the keyboard typing. [SB13] This trend is quickly developing[SB14] and keyboard typing maybe [SB15] will substitute classical writing with pen and paper. Aim: The aim of this study is [INS: to :INS] [DEL: find :DEL] [INS: identify the :INS] differences between handwriting with pen and paper and keyboard typing [DEL: and :DEL] [INS: by :INS] mapping areas of the brain activated during these processes. Our attention is oriented to[INS: the :INS] peripheral processes of writing. Methods, procedures: Functional magnetic resonance imaging [INS: (fMRI) :INS] was used with [DEL: fourteen :DEL] [INS: 14 :INS] [INS: [SB16] :INS] [INS: [SB17] :INS] healthy volunteers [DEL: in :DEL] age[INS: d between :INS] 23–33 years, native Czech speakers, to examine [INS: the :INS] [INS: brain :INS] [DEL: activation :DEL] [INS: activity :INS] involved in writing. [INS: The :INS] [DEL: E :DEL] [INS: e :INS] xperimental design of[INS: the :INS] protocol was divided into three parts: handwriting of words, keyboard typing of words and silen[INS: t :INS] [DEL: ce :DEL] spelling of words contrasted with motor control using pen and keyboard and with control using subvocal naming of alphabet matched to each task. Conclusion[SB18] : We found differences between handwriting and keyboard typing in three areas in the brain. In all areas[INS: , a :INS] [DEL: was found :DEL] stronger activation during keyboard typing task[INS: was found :INS] . The first area is [INS: the :INS] occipital lobe which is responsible for visual control. The second area is [INS: the :INS] parietal lobe – superior parietal lobe and inferior parietal sulcus. These brain parts are associated with planning and performing [DEL: of a :DEL] complex [DEL: of :DEL] moving sequences. [INS: The l :INS] [DEL: L :DEL] ast activated area is dorsal attention network[DEL: , :DEL] [INS: ; a :INS] probable explanation of this fact is that handwriting is [INS: an :INS] overlearned process and during keyboard typing is required more attention. [SB19] [DEL: In :DEL] [INS: T :INS] [DEL: t :DEL] his paper [DEL: is :DEL] describe[INS: s :INS] [DEL: d :DEL] the first resolution of our pilot fMRI study of handwriting and keyboard typing. The[DEL: se :DEL] findings provide new insight into neural processes involved in handwriting and keyboard typing.[INS: :INS] [INS: :INS] 6. Miroslava Protein structures and their interaction with ligands have been [DEL: in :DEL] the focus of biochemistry and structural biology research for decades[SB20] . Traditionally[INS: , :INS] the interaction is [SB21] represented by a ligand that follows a path (tunnel) from the outer solvent to the active site where it can react. This transportation can be [INS: a :INS] very lengthy and complex process that is influenced and driven by both geometric and physico-chemical properties of the ligand and the amino acids surrounding the tunnel. When studying this process in molecular dynamics simulations, [INS: a :INS] proper understanding of ligand behavior inside the tunnel is crucial. Therefore, in this paper, we propose a novel method for[INS: the :INS] interactive exploration of ligand transportation to the active site. As the path of the ligand is usually very jittered and full of impasses, we introduce a path simplification model that emphasizes the main direction of ligand motion. We [INS: also :INS] propose a new conceptual representation, [DEL: so-called :DEL] [INS: namely :INS] temporal tunnel, and show its main properties that include description of surrounding amino acids. By interacting with this representation, a user can explore the overall characteristics of the temporal tunnel as well as [SB22] selected portions of the original ligand movement. This approach could easily guide users to choose simulation frames containing important ligand movements that drive the ligand to the active site. Additionally, our simplified representation decreases the length of the molecular dynamics simulation, which reduces the time spent on this analysis. The proposed method was applied [DEL: on :DEL] [INS: to :INS] the simulations captured by the biochemists who also evaluated the method.[INS: :INS] 7. Katerina Research focused on the process of sharing a tacit knowledge between a student teacher and its training teacher. [SB23] It [SB24] is the tacit knowledge which arose [SB25] from the process of sharing. Tacit knowledge [SB26] is highly individual, [DEL: hardly :DEL] [INS: barely :INS] expressible, arising from the subjective experience of the individual and reflected in his actions especially when dealing with unexpected situations[INS: , :INS] and interpreted during self-reflection. The aim of th[INS: is :INS] [DEL: e :DEL] research is to identify tacit knowledge which student teacher and training teacher share. Sharing between student and training teacher is based on their mutual cooperation and shall be conducted in a model of collaborative apprenticeship. [SB27] [INS: A :INS] Train[INS: ee :INS] [DEL: ing :DEL] teacher approaches his [SB28] experiential background in accordance with the positive development of the student teacher. Data was collected [DEL: by :DEL] [INS: through :INS] in-depth interviews inspired by the method of clean language. The research revealed three categories of tacit knowledge, which have different meaning[INS: s :INS] on the base of student‘s subjective theory.[SB29] These categories of tacit knowledge are basically [SB30] made explicit by training teacher. The first category is the tacit knowledge that is part of not only the student's thinking, but [DEL: it :DEL] manifest[DEL: s :DEL] [INS: ed :INS] [DEL: itself :DEL] in his/her acting[SB31] . The second category is a category that is part of the student's thinking, [DEL: and :DEL] [INS: where the :INS] student has a positive attitude [DEL: with :DEL] [INS: surrounding :INS] this tacit knowledge, [DEL: but :DEL] [INS: although this :INS] is not demonstrated in his [DEL: acting :DEL] [INS: actions :INS] . The third category is the category that is in student thinking as well as acting, but the student has [INS: an :INS] opposite view to this category of tacit knowledge. Each category is demonstrated [INS: i :INS] [DEL: o :DEL] n the data from the interviews. It is also presented how student teacher acquires teacher’s tacit knowledge [DEL: with :DEL] [INS: in :INS] accordance [DEL: of :DEL] [INS: with :INS] his/her subjective theory. [DEL: As a :DEL] [INS: In :INS] conclusion, research revealed that acquired tacit knowledge needs lived experience.[INS: :INS] 8. Petr [INS: The :INS] Banking industry is considerably more regulated, therefore supposedly more limited in its manoeuvre capacity, than other spheres of economy. However, even financial companies nowadays increasingly outsource and offshore their activities. The concept of shared services is a way of internal outsourcing when the destination of relocated activities remains within the organizational structure of a company in the form of [INS: a :INS] shared services center[INS: , :INS] but the relationship between this center and the rest of [DEL: a :DEL] [INS: the :INS] company has features typical for outsourcing. The research question of this paper is: What are the motivations of the relocation of activities to the shared services center (SSC) and how[INS: do :INS] the perceptions of these motivations by actors influence [DEL: a :DEL] [INS: the :INS] process of [DEL: the :DEL] relocation? [INS: :INS] [INS: :INS] [DEL: The :DEL] [INS: This :INS] paper is based on the first case study carried out in the framework of dissertation research which aims to explore the establishment of two shared services centres in two central European countries by two multinational banks domiciled in Western Europe. The presented case study is based on twenty semi-structured interviews. I argue that the position of the SSC is initially extremely uncertain and instable which constrain[INS: s :INS] the SSC’s management to embrace [INS: an :INS] aggressive strategy in order to strengthen the SSC’s position. However, this strategy further reinforces the dynamics of the transfer of activities and leads to other form[INS: s :INS] of implementation of empowered monitoring and controlling mechanisms experienced not only by the SSC[INS: , :INS] but also by lower [SB32] management and employees in the country of origin. On the basis of labour process theory[INS: , :INS] I conclude that the main reason [DEL: of :DEL] [INS: behind :INS] shared services implementation is [INS: the :INS] [DEL: a :DEL] management’s effort to enhance its control of [INS: the :INS] labour process. This increase [DEL: of :DEL] [INS: in :INS] control is related to [INS: the :INS] increased intensity of work, increased[SB33] division of labour and heightened job insecurity.[INS: :INS] 9. Vendula Strategic Communication (abbr. [SB34] StratCom) represents a progressive concept in relation to asymmetric warfare. It has [DEL: been :DEL] already [INS: been :INS] acknowledged that the centre of gravity of [DEL: the :DEL] today’s and possible future counterinsurgency operations [DEL: is lying :DEL] [INS: lies :INS] in [DEL: the :DEL] population-centric approaches. However, the persuasion of the population takes place to a large extent in the non-kinetic, information domain. Military actions are still vital[INS: , allthough :INS] but [SB35] the information activities will be most probably as important or even of greater importance. As StratCom is a rather new concept surrounded by many ambiguities, the primary goal of th[INS: is :INS] [DEL: e :DEL] paper is to introduce its definitions and outline its boundaries with related concepts (public diplomacy, psychological operations, information operations etc.). Subsequently, the use of [DEL: the :DEL] strategic communication in the official NATO documents and counterinsurgency operations (ISAF mission) will be described. The paper finally discusses whether the Alliance employed this approach successfully and tries to identify possible limitations. It arrives [DEL: to :DEL] [INS: at :INS] the conclusion that the concept has been applied in harmony with the Alliance’s counterinsurgency strategy and its comprehensive approach to crisis management. However, it has been adopted at the highest level of the organization only and furthermore [SB36] it has not been embraced by all member states. Even though StratCom did address some of the earlier failures and shortcomings of the Alliance in the information sphere, there are some limitations - some of them inherent to the organization’s structure itself - which raise[INS: s :INS] [DEL: a :DEL] doubt[INS: s :INS] [INS: about :INS] whether [DEL: any :DEL] successful execution of the strategic communication by NATO is actually feasible. 10. Barbora The Arctic is undoubtedly a relevant geopolitical region [SB37] with a specific environment and shared history, interlinked with clearly defined relations of cooperation and confrontation and the awareness of the growing strategic potential shared by all regional actors. With the end of [INS: the :INS] Cold War, [DEL: the :DEL] regional security has become [SB38] more important. The Copenhagen school develops [SB39] a theory of regional security complex (RSCT), which constitutes the most comprehensive framework for [INS: the :INS] analysis of regional security dynamics. Buzan and Wæver distinguish regional security complexes (RSC) around the world, however they haven´t [SB40] included the Arctic or polar territories as such. The aim of this paper is to analyze whether the Arctic region can be defined as a distinct RSC. Moreover, it seeks [DEL: the answer, :DEL] [INS: to establish :INS] whether it [DEL: was :DEL] [INS: can be :INS] substantiated[DEL: , :DEL] that authors of the theory left out the Arctic behind [SB41] without classification as an individual RSC. The major part of the paper analyzes two criteria necessary for the classification of the regional security complex. First, the interconnection of the major securitization and/or desecuritization processes. Second, the condition of fulfilling four variables of the essential structure of the RSC. If the Arctic region in its structure corresponds to the essential structure of the RSC and the main (de)/securitization processes show strong consistency, it is possible to classify the Arctic as a regional security complex.[INS: :INS] 11. Šárka In certain legal conditions, psychologists belong to the healthcare workers as well[SB42] . The role of [INS: the :INS] psychologist is specific, [INS: but :INS] not always respected. In the [SB43] article the[DEL: re :DEL] [DEL: are discussed :DEL] differences between psychiatrics and psychologists[INS: are discussed :INS] . Competence conflict is presented by conclusions of Czech Medical Association and Association of Clinical Psychologists. In terms of [DEL: the :DEL] Act no. 372/2011 Coll., and [DEL: the :DEL] Act no. 96/2004 Coll., [DEL: was :DEL] [INS: these :INS] distinguished between clinical psychologist and psychologist in health. If [INS: a :INS] psychologist is entitled to [DEL: work :DEL] [INS: employment :INS] as a healthcare worker, [INS: s/he :INS] has to respect ethical principles as well as lege artis principles. Th[INS: is :INS] [DEL: e :DEL] article conceives cross-sectoral overlap in psychology and ethics. ________________________________ [SB1]This could also be placed at the start of the sentence [SB2]A disruption to... Disrupting these... [SB3]This does not follow on coherently from the previous clause [SB4]The present tense tends to be used when identifying aims [SB5]Two points: 1) Avoid repetition where possible 2) This expression is semi-formal [SB6]Vague...‘a variety of‘ would be less so [SB7]Again, semi-formal [SB8]documents (verb) is usually followed by the alternatively, write: This study highlights that... [SB9]rephrase [SB10]rephrase (e.g.: ...this paper urges/recommends...) [SB11]unclear [SB12]collocation is: In everyday life... [SB13]ungrammatical [SB14]the tense use might need to be reconsidered here, as this suggests a recent development/change, while this started some time ago... [SB15]colloquial [SB16] [SB17]numerals can be used for numbers 10 and over [SB18]what you present here is more like your Results [SB19]unclear [SB20]semi-formal [SB21]check tense...the present perfect is better suited to the word ‚traditionally‘ [SB22]in addition to is more formal [SB23]this sentence is incomplete [SB24]this sentence does not follow on coherently from the previous one [SB25]tense use unclear here [SB26]avoid repetition in quick sucession [SB27]unclear [SB28]his/her [SB29]rephrase [SB30]colloquial [SB31]actions [SB32]middle? [SB33]Minimise repetitious language; consider synonyms for increase [SB34]Not necessary; just give the abbreviation/initialism in brackets [SB35]But = offers a contrast as a coordinating conjuction, while although is a subordinating conjuction [SB36]Both are not needed here.. [SB37]It is not clear what this is specifically in relation to [SB38]Check tense... [SB39]As above [SB40]Do not use contractions in academic writing [SB41]...check and remove superfluous word(s) [SB42]Misplaced here, and also appearing colloquial t [SB43]his?