(1) Lubomira Anderkova Introduction[SB1] : Repetitive transcranial magnetic stimulation (rTMS) is a non[INS: - :INS] invasive tool for modulating cortical activity. Objectives: We studied [INS: the :INS] effects of high frequency rTMS applied over the right inferior frontal gyrus (IFG) and the right superior temporal gyrus (STG) on cognitive functions in patients with amnestic mild cognitive impairment (MCI) and incipient dementia due to Alzheimer´s disease (AD). Methods: Ten patients (6 men; 4 women, mean age 72 ± 8 years; MMSE 23 ± 3.56) were enrolled in the randomized, placebo-controlled study with a crossover design. All participants underwent 3 sessions of 10 Hz rTMS over the non-dominant right hemisphere (2250 stimuli/day, intensity 90% of motor threshold) in [DEL: a :DEL] random order: 1. IFG (an active stimulation site), 2. STG (an active stimulation site), 3. vertex (a control stimulation site). The Trail Making Test (TMT), the Stroop test and the visual memory encoding task (VMET) were administered before and immediately after each session. The Wilcoxon paired test was [INS: then :INS] used for data analys[DEL: e :DEL] [INS: i :INS] s. Results: Only [SB2] the stimulation applied over the IFG induced significant improvement in the TMT part A (p = 0.037) and B (p = 0.049). No significant changes were found in the Stroop test and in the VMET after the IFG stimulation. Moreover, [DEL: we observed :DEL] [SB3] no significant cognitive after-effects of rTMS applied over the STG and/or vertex[INS: were observed :INS] . Conclusions: High frequency rTMS of the right IFG induced significant improvement of attention and psychomotor speed in patients with MCI and dementia due to AD. This is an interim analysis of an ongoing study.[SB4] [DEL: :DEL] (2) Andrea Belanova When Messiah Dies: Unification Church Members’[SB5] Perceptions of Reverend Moon’s Death Abstract of the Conference Paper The[SB6] analysis focuses on the reactions of the Unification Church members to the death of the [SB7] leader, and to the articles that appeared in the media [DEL: and :DEL] referr[INS: ing :INS] [DEL: ed :DEL] to this event. Reverend Sun Myung Moon, the founder of [INS: the :INS] new religious movement Unification Church, died at the age of 92 in South Korea in September 2012. Surprisingly, his death was received [INS: with relative calm mind :INS] by [DEL: the :DEL] [INS: his :INS] church members[DEL: with relative calm mind :DEL] . They smoothly [SB8] organized the funeral ceremony and [SB9] the officials claimed that his death is understood only as a transformation into another state of being, and it [DEL: thus :DEL] should [INS: thus :INS] be celebrated. However, Moon’s death also attracted a lot of [SB10] media attention, mostly in the negative sense. The emotions were suddenly churned up [SB11] around the death of the man, who claimed himself [DEL: as :DEL] [INS: to be the :INS] Messiah and True Father of mankind. Considering the data including [SB12] specifically interviews and written texts, I conducted a case study [INS: analysis :INS] using the methods of qualitative sociology to investigate this unique situation. In my paper[INS: , :INS] I argue that the reactions of the members are ambivalent in nature depending on the further context. [SB13] Although Moon’s death is viewed as [DEL: a :DEL] “not a sad event” by the Unificationists according to the theology;[SB14] they demand respect and compassion for their grieving [DEL: at the same time when it concerns :DEL] [INS: rather than :INS] media attention. The inner life of the church and the public image are thus understood as two different worlds where different emotions should be presented. The analysis shows how the “sacred” aspect may be protected from [DEL: the :DEL] [INS: a :INS] profane world by [DEL: the :DEL] religious movements. [DEL: :DEL] [INS: :INS] (3) Jana Pazurikova Molecular dynamics simulations of longer simulations [SB15] times (~ tens of μs and more) capture events of great chemical and biological interest. Parallel-in-space runs of these simulations hit the strong scalability wall—[SB16] adding more processors does not shorten the time to results[SB17] . Inspired by gravitational N-body simulations, we propose the algorithm calculating molecular dynamics parallel in time. Our implementation of[INS: the :INS] parareal method combined with [INS: the :INS] multilevel summation method for [INS: the :INS] evaluation of long-range interactions achieved almost perfect [SB18] strong scaling up to half a million cores. Thus, compared to the simulation sequential in time, we reduced the wallclock time of simulation by an order of magnitude. Shortening the calculations can push [DEL: the :DEL] research in medicine and pharmacy further as it condenses the time from an idea to the evaluation of simulated experiment.[INS: :INS] [INS: :INS] [DEL: :DEL] (4) Martin Jirusek Strategic and market-oriented a[SB19] pproaches to energy policy [SB20] in policy documents of the Czech Republic and European Union The EU has been gradually increasing [DEL: the :DEL] [INS: its :INS] emphasis on common approach[INS: es :INS] to energy security among its members in [INS: the :INS] last couple of years [SB21] [DEL: and :DEL] [INS: meaning :INS] these states [DEL: had to :DEL] [INS: were required to :INS] reflect [INS: on :INS] this tendency in their own approach to energy policy. Additionally, both [INS: the :INS] EU and its members[SB22] were forced to react [DEL: on :DEL] [INS: to :INS] several challenges regarding energy security. Reactions and tendencies within energy policies could be assessed on the basis of theoretical approaches that can not only clarify reasons for implementing specific tools and procedures, but [INS: can :INS] also [DEL: can :DEL] help to anticipate future development. This article [DEL: is :DEL] focuse[INS: s :INS] [DEL: d :DEL] on [INS: the :INS] energy policy of the Czech Republic and European Union from the perspectives of [INS: the :INS] strategic and market-oriented approach which are the two dominant theoretical approaches in this field of study[SB23] . The aim was [SB24] to identify how these approaches are reflected in policy documents [DEL: on :DEL] [INS: at :INS] both levels during the [DEL: selected :DEL] period [DEL: of time ( :DEL] 2004-2012[INS: , :INS] [DEL: ) :DEL] and what [DEL: does it :DEL] [INS: this :INS] mean[INS: s :INS] in terms of energy policy coordination within the EU. [DEL: :DEL] (5) Monika Schön This essay deals with [SB25] [DEL: the :DEL] matters [INS: pertaining to the :INS] [DEL: of :DEL] [INS: :INS] education of a child [DEL: and :DEL] [INS: where :INS] a possible conflict of opinions among the persons who realize the education of a child[INS: may arise. This :INS] [INS: subject :INS] [INS: is explored :INS] , [DEL: in the light of :DEL] [INS: with reference to :INS] the Convention for the Protection of Human Rights and Fundamental Freedoms (hereinafter „Convention“), before all art. 8, art. 9 of the Convention and art. 2 of the Protocol No. 1.[SB26] The essay does not focus only on the right to education which belongs to the child´s parents[SB27] , [DEL: eventually to other persons (such as :DEL] [INS: and the involvement of the S :INS] [DEL: s :DEL] tate), but also on the right to education which belongs to the child and [DEL: o :DEL] [DEL: n :DEL] the interest[INS: s :INS] of [DEL: a :DEL] [INS: that :INS] child to be educated. [DEL: :DEL] (6) Petr Dvorak Institutional Responsiveness in Parliamentary Democracies:[INS: A :INS] Longitudinal Study The [SB28] paper proposes a research framework to analyse institutional responsiveness and parliamentary regime[INS: s :INS] in established parliamentary democracies. [INS: A p :INS] [DEL: P :DEL] arliamentary regime is a good indicator of an overall democracy type. Traditionally, three main types of parliamentary regimes have been described: Westminster-style, cooperative, and chaotic. These regimes have been associated with different logic[INS: s :INS] of operation, different degree[INS: s :INS] of intra-institutional political conflict, and different models of responsiveness. Moreover, they have been seen as stable, fixed attributes. Th[DEL: e :DEL] [INS: is :INS] paper argues that components of parliamentary regime[INS: s :INS] such as the degree of government dominance and the degree of intra-parliamentary cooperation can vary significantly [DEL: in :DEL] [INS: over :INS] time. In a wider context, they can contribute to our understanding of long-term evolution of representative democracy. Inspired by recent debates on [DEL: the :DEL] [INS: different :INS] types of democracy, the paper introduces a research framework based on a longitudinal analysis of two institutional features: (1) government dominance in key parliamentary committees, [INS: and :INS] (2) cohesion of government in parliamentary voting. In [INS: its :INS] [DEL: the :DEL] preliminary analysis, the paper analyses data from five established parliamentary democracies (known for different typical coalition patterns) [DEL: from the period of :DEL] [INS: over the :INS] last twenty years. The results indicate that while the degree of dominance in parliamentary committees remains stable, the levels of voting cohesion [SB29] [DEL: keep :DEL] [INS: undergo significant :INS] chang[INS: e :INS] [DEL: ing significantly :DEL] . Therefore, types of parliamentary regime[INS: s :INS] and types of responsiveness in established countries are indeed evolving. [DEL: :DEL] (7) Martin Vrubel Barriers to school [SB30] i[SB31] nclusion of students with visual impairment in high schools This article describes how high schools are prepared for the inclusion of students with visual impairments[DEL: . It :DEL] [INS: and :INS] focuses on the importance of school management attitudes to [DEL: the :DEL] inclusive education. Furthermore, it discusses the impact of school management on inclusive education[SB32] . This article also describes our research of the topic of inclusion, which was carried out [SB33] in cooperation with 250 [INS: H :INS] [DEL: h :DEL] eads of high schools in the East Bohemian Region. The paper summarizes the phase of a larger research project, which deals with[SB34] the issue of inclusion of students with visual impairments. This paper [SB35] presents some of the partial results, such as the comparison between the significance of headmaster [SB36] attitudes to the hard and soft barriers (external financial resources, teaching assistants, teacher training in special education, architectural barriers, teacher collaboration, attitudes of parents and children, and legislative support for inclusive education), and the importance of the same barriers to the particular institution. This text also presents headmaster attitudes to different types of visual impairment. [DEL: :DEL] (8) Durdica Marosevic In v[SB37] ivo spread of macrolides-lincosamides-streptogramin B (MLSB) resistance – a model study INTRODUCTION: The extensive use of antimicrobial agents in animal husbandry poses a risk for the [SB38] selection of resistant microorganisms. The gastrointestinal tract of animals was already defined [SB39] as rich in a variety of resistance genes and such animals can serve as reservoirs of resistant bacteria or genetic determinants of resistance that can be transmitted to humans. METHODS: Four[INS: - :INS] [DEL: :DEL] week[DEL: s :DEL] old chickens colonized with Enterococcus faecalis carrying pAMβ1 (the challenge strain) were per orally exposed to three different antibiotics (tylosin, lincomycin and chlortetracycline) during [INS: the period of :INS] one week. Faecal samples and cloacal swabs were taken at four different [DEL: time p :DEL] oints and isolates of resistant E.faecalis and E.faecium were subjected to PFGE (pulsed-field gel electrophoresis) and plasmid isolation. The erm(B) gene was quantified in the DNA isolated from faeces by qPCR. The same DNA was [INS: then :INS] subjected to 16S-rDNA pyrosequencing in order to [DEL: get :DEL] [INS: gain :INS] better insights into the faecal microbiota composition and changes induced by the different antibiotics administered. RESULTS: A total of 77 enterococci and 22 streptococci were isolated. Two PFGE clones of each E.faecalis and E.faecium were observed, all different [DEL: from :DEL] [INS: to :INS] the challenge strain. All isolates of enterococci and streptococci harboured a plasmid of the same size as that of pAMβ1. qPCR revealed an increase of erm(B) in all treated groups [DEL: during the whole :DEL] [INS: throughout the :INS] monitored period, whereas the challenge species E. faecalis rapidly declined over time. The impact of a non-specific antibiotic pressure represented by TET was similar to that of TYL and LIN, furthermore, in two out of five chickens from the NCO group[INS: , :INS] a significant increase of erm(B) was detected at the last sampling point. This is an[DEL: :DEL] interesting finding indicating that [INS: the :INS] spread of genetic determinants of MLSB resistance may be independent not only o[INS: ne :INS] [DEL: f :DEL] the specificity of antibiotic pressure[INS: , :INS] but also o[INS: n :INS] [DEL: f :DEL] the antimicrobial pressure[INS: , :INS] per se[SB40] . A similar phenomenon was also observed under field conditions where MLSB resistant bacteria were isolated from piglets which had never before been treated with macrolides or lincosamides. The relative composition of faecal microflora was dependent on the antibiotic administrated and the sampling time point. Although th[INS: e :INS] [DEL: is :DEL] results do not supply the exact information on the spread of MLSB resistance; however[SB41] , as observed for enterococci, these correlated with the qPCR results. CONCLUSIONS: The erm(B) gene increased in all the treated groups and[SB42] , therefore, it could be speculated that those bacterial taxons which prevailed under certain conditions might be considered as potential recipients. Thus it could be presumed that MLSB resistance can spread in different ways[INS: , :INS] depending on the particular antibiotic pressure. [DEL: :DEL] (9) Tereza Ceskova A Progress of Tools [SB43] for Investigation of the Learning Tasks in Czech Basic School Instruction during[INS: the :INS] Last 25 Years Th[INS: is :INS] [DEL: e :DEL] poster presents a 25-year-long progress of tools [INS: used to :INS] [DEL: for a :DEL] research [DEL: of :DEL] learning tasks in the basic school instruction in the Czech Republic. [SB44] We perceive a learning task[DEL: s :DEL] as an opportunity to learn and we suppose that one of their main function[INS: s :INS] is to activate [SB45] pupils. Contemporary concept[DEL: ion :DEL] [INS: s :INS] of [DEL: the :DEL] Czech instruction stress[DEL: es :DEL] [INS: the importance of :INS] not only [DEL: a :DEL] content knowledge[INS: , :INS] but also [INS: of :INS] [DEL: a :DEL] developing [DEL: of :DEL] the key competencies. [DEL: :DEL] [INS: :INS] [INS: :INS] (10) Eva Lysonkova DEMOCRATICALLY-RUN BUSINESSES IN THEORY AND IN REALITY Due to the development of society, technology, work characteristics [SB46] and the change of employee[DEL: s :DEL] and employer[DEL: s :DEL] requirements of work[INS: , :INS] new alternatives are emerging within the modern approach to human resources management. The concept of democratically-run businesses is one of these approaches. This article aims [SB47] to introduce and define the concept of [SB48] democratically-run businesses. Firstly [SB49] democratically-run businesses are characterized, secondly they are defined from the perspective of theory and thirdly from the point of [DEL: view of :DEL] practitioners. Lastly, the article mentions the main reasons for the further investigation of democratically-run businesses. [DEL: :DEL] [INS: :INS] [INS: :INS] (11) Saman Pushpakumara Edmund Husserl’s Transcendence of the Early Buddhist Theory of Consciousness [DEL: :DEL] Edmund Husserl, the founding father of [DEL: the :DEL] western phenomenology, had formulated [SB50] a theory of the consciousness. The Gautama the Buddha, too [SB51] as far back as the 6^th century B.C., had provided an analysis of the conscious phenomena. Many scholars who trace parallels between the Buddhist view of consciousness and Husserl’s phenomenology deal mostly with[SB52] the similarities between the two philosophies. The present [SB53] paper argues that Husserl's analysis of consciousness, despite its limitations, is more advanced than the Buddha's formulation. Husserl articulated his phenomenology of consciousness as a result of his encounter with Cartesian cogito on the one hand[INS: , :INS] and the positivistic foundation of empirical sciences on the other. [INS: :INS] [INS: :INS] Husserl’s notion of phenomenological consciousness was situated within an industrially advanced capitalist society and nurtured by scientific epistemology. He was living in a different T[SB54] ime-Space dimension, which has to be taken seriously[SB55] when assessing his phenomenology. The Buddha, in contrast, theorized his notion of consciousness within a backward, slow-moving, agricultural and feudal setting, and developed his notion of consciousness as a normative concept, as a basis for achieving the spiritual objective he envisaged. While acknowledging the fact that no other philosophy[DEL: , :DEL] which existed during the Buddha’s time[DEL: , :DEL] had articulated such a meticulous and in[INS: - :INS] [DEL: :DEL] depth analysis of the phenomenology of consciousness, his analysis seems to be less advanced when assessed and compared with the twentieth century phenomenology of Husserl. [DEL: Present study will be carried out :DEL] [INS: This study :INS] [DEL: havi :DEL] [DEL: ng :DEL] use[INS: s :INS] [DEL: d :DEL] [DEL: original :DEL] [INS: both primary :INS] and secondary sources of Husserlian and Buddhist phenomenologies. [INS: It is hoped that t :INS] [DEL: T :DEL] his research will [DEL: immensely :DEL] contribute [INS: immensely :INS] to [DEL: the :DEL] future researches[SB56] on similar topic[INS: s :INS] [INS: :INS] [DEL: . :DEL] (12) Blanka Kubesova TP53 m[SB57] utated clones in MPN patients Myeloproliferative neoplasms (MPN) are diseases with chronic course[SB58] but with a risk of transformation into secondary acute myeloid leukemia. Several mutations and cytogenetic aberrations were published to be associated with transformation but its [SB59] mechanism still remains unclear. Lesions in the pathway of the gene TP53 are considered to play an important role in the transformation. [DEL: Part :DEL] [INS: Some patients with :INS] [DEL: of the :DEL] MPN [DEL: patients is :DEL] [INS: are :INS] treated long[DEL: :DEL] [INS: - :INS] term with low doses of hydroxyurea as a cytoreductive agent. This drug was reported by several authors as mutagenic and leukemogenic and associated with the defects in the gene TP53 and transformation. [DEL: In o :DEL] [INS: O :INS] ur study [DEL: are :DEL] include[INS: s :INS] [DEL: d :DEL] patients in [INS: the :INS] chronic phase of the[INS: ir :INS] disease. The aim [INS: of this work :INS] is to identify, analyse and monitor patients with mutations in the gene TP53. Consequently the frequency of the occurrence of TP53 mutated clones, the relationship of their presence and the evolution of the disease and the type of treatment are evaluated. Leukocytes are obtained from patient blood samples. [DEL: Subsequently :DEL] [INS: T :INS] [DEL: t :DEL] he RNA is [INS: subsequently :INS] isolated from these samples and transcribed into cDNA. The[INS: :INS] [DEL: n the :DEL] samples are [INS: then :INS] analysed [DEL: by :DEL] [INS: using :INS] the method FASAY (functional analysis of separated alleles in yeast)[INS: ; :INS] [DEL: and :DEL] yeast colonies containing mutated TP53 gene are sequenced by Sanger sequencing. Mutations in the gene TP53 were found in 3/18 patients treated [DEL: by :DEL] [INS: using :INS] hydroxyurea[INS: , :INS] and in 1/22 patients treated [INS: with a :INS] [DEL: by :DEL] different cytoreductive drug. In one patient treated by hydroxyurea[INS: , :INS] the mutated clone expanded by the time of monitoring and the second healthy allele was almost lost. Clinically[INS: , :INS] the patient is stable. Current results suggest that the treatment with hydroxyurea could represent a selection pressure supporting the expansion of clones with mutated gene TP53. ________________________________ [SB1]This seems rather short for an introduction, and is almost akin to a title... [SB2]Initial point use of this word is more common in spoken English. [SB3]Removed for the sake of consistency [SB4]Misplaced here...you may, instead, start the conclusion by stating, In the interim stage of this ongoing study, it was found that... [SB5]Where possible, avoid the possessive apostrophe in academic writing: instead, create noun combinations, for example: Church Member Perceptions [SB6]Use This as this is the first reference to the analysis [whereas the would typically be used in cataphoric referencing] [SB7]their? [SB8]Vague: do you mean swiftly...and well-planned? [SB9]Inappropriate addition here as the two clauses are unrelated [SB10]colloquial [SB11]colloquial [SB12]rephrase [SB13]unclear [SB14]not used here when Although is used at the start of the sentence [SB15]conisder how/whether repeated use of simulations can be avoided in such close proximity within the sentence [SB16]only use where necessary: the comma or a conjuction would be preferable here [SB17]unclear [SB18]colloquial; faultless may be a possible alternative [SB19]content words in headings and subheadings are usually capitalised [SB20]is this word needed here [if policy documents are subsequently referred to]? [SB21]colloquial [SB22]what’s the difference? [SB23]tautological [SB24]use the present tense [SB25]avoid phrasal verbs in academic writing [SB26]this sentence is quite long and difficult to follow: i would recommend that it is restructured for greater clarity [SB27]this expression means that it is the parents who are being educated...do you mean the rights of parents to make decisions about schooling for their children? [SB28]This [SB29]Is hedging needed here? [i.e. tend to undergo...?] [SB30]Reconsider the need for the word school twice in this title/heading [SB31]The content words in headings and subheadings tend to be capitalised [SB32]repetitious [SB33]avoid phrasal verbs in academic writing [SB34]See above [SB35]Avoid repetitive grammatical structures... [SB36]Headteacher would be preferable [SB37]Capitalise content words [SB38]Which ones does this refer to? [SB39]When, and by whom? [SB40]Inappropriate use here [SB41]Not used in conjunction with although at the start of a sentence [SB42]superfluous [SB43]? [SB44]Needs to be rephrased to create greater clarity [SB45]Wrong word: [SB46]An odd collocation...what do you mean here? [SB47]You may want to combine these sentences so as to create better sentence cohesion [SB48]There is considerable repetition of this key term in such a small extract: consider the use of anaphoric and cataphoric referencing, and the use of synonyms/pronouns, where possible [SB49]While this style of listing/structuring the work is fine, you may want to try something along the lines of: The paper will begin by...after which it will...Finally, the article.... [SB50]Use the past simple [SB51]? [SB52]Semi-formal...avoid phrasal verbs in academic writing [SB53]This [SB54]Is capitalisation necessary here...? [SB55]Semi-formal. Consider: warrants serious consideration instead [SB56]uncountable [SB57]it is common to capitalise content words in headings and subheadings [SB58]i am not sure why this word has been insrted here...? [SB59]several...therefore their