#position:IFNAR_complex:1345.9000702936446,365.1664263413548
$IFNAR_complex:true
#position:IFNA1_IFNAR_complex:1862.772727272727,284.6590909090909
$IFNA1_IFNAR_complex:(IFNAR_complex & IFNA1_extracellular_space)
IFNAR_complex -> IFNA1_IFNAR_complex
IFNA1_extracellular_space ->? IFNA1_IFNAR_complex
#position:IFNA1_extracellular_space:1532.9929799569895,137.71023178259867
#position:IFNA1_out:2148.8773906509377,2898.7670632679346
$IFNA1_out:IFNA1_rna
IFNA1_rna -> IFNA1_out
#position:IFNA1_rna:2228.8576115073542,2782.6714397788182
$IFNA1_rna:((AP_1_complex_nucleus & NFKB1_nucleus) & p50_p65_complex_nucleus)
AP_1_complex_nucleus -> IFNA1_rna
NFKB1_nucleus -> IFNA1_rna
p50_p65_complex_nucleus -> IFNA1_rna
#position:AP_1_complex_nucleus:3571.5,2777
$AP_1_complex_nucleus:(AP_1_complex_cell & !Azithromycin_drug)
AP_1_complex_cell -> AP_1_complex_nucleus
Azithromycin_drug -| AP_1_complex_nucleus
#position:NFKB1_nucleus:3050.5,2902.5
$NFKB1_nucleus:(NFKB1_cell & !Azithromycin_drug)
NFKB1_cell -> NFKB1_nucleus
Azithromycin_drug -| NFKB1_nucleus
#position:p50_p65_complex_nucleus:3383.75,2961
$p50_p65_complex_nucleus:(p50_p65_complex_cell & !Azithromycin_drug)
p50_p65_complex_cell -> p50_p65_complex_nucleus
Azithromycin_drug -| p50_p65_complex_nucleus
#position:IFNB1_IFNAR_complex:2110.122153616756,405.09231593423607
$IFNB1_IFNAR_complex:(IFNAR_complex & IFNB1_extracellular_space)
IFNAR_complex -> IFNB1_IFNAR_complex
IFNB1_extracellular_space ->? IFNB1_IFNAR_complex
#position:IFNB1_extracellular_space:2336.1427492706434,143.5808027040964
#position:IFNB1_out:2557.62820570015,2927.8153445404673
$IFNB1_out:IFNB1_rna
IFNB1_rna -> IFNB1_out
#position:IFNB1_rna:2638.2802789486495,2639.5049106499064
$IFNB1_rna:((AP_1_complex_nucleus & NFKB1_nucleus) & p50_p65_complex_nucleus)
AP_1_complex_nucleus -> IFNB1_rna
NFKB1_nucleus -> IFNB1_rna
p50_p65_complex_nucleus -> IFNB1_rna
#position:STAT1:1491.5,952.5
$STAT1:true
#position:STAT1_2_IRF9_complex:1395,1226
$STAT1_2_IRF9_complex:(((((TREML4 | JAK1_TYK2_complex) & STAT1) & IRF9) & STAT2) & !Orf6)
STAT1 -> STAT1_2_IRF9_complex
IRF9 -> STAT1_2_IRF9_complex
STAT2 -> STAT1_2_IRF9_complex
Orf6 -| STAT1_2_IRF9_complex
TREML4 -> STAT1_2_IRF9_complex
JAK1_TYK2_complex -> STAT1_2_IRF9_complex
#position:IRF9:1361.5,979.5
$IRF9:true
#position:STAT2:1623,979.5
$STAT2:true
#position:Orf6:2669,738
#position:TREML4:2629.5,403.5
#position:JAK1_TYK2_complex:1680.5,670.5
$JAK1_TYK2_complex:(((IFNA1_IFNAR_complex | IFNB1_IFNAR_complex) & JAK1) & TYK2)
JAK1 -> JAK1_TYK2_complex
TYK2 -> JAK1_TYK2_complex
IFNA1_IFNAR_complex -> JAK1_TYK2_complex
IFNB1_IFNAR_complex -> JAK1_TYK2_complex
#position:JAK1:2299.272727272727,715.1590909090909
$JAK1:true
#position:TYK2:2300.772727272727,801.2272727272726
$TYK2:true
#position:ISRE_complex:1318.863636363636,2790.8333333333335
$ISRE_complex:(STAT1_2_IRF9_complex & !Azithromycin_drug)
STAT1_2_IRF9_complex -> ISRE_complex
Azithromycin_drug -| ISRE_complex
#position:Azithromycin_drug:3232.5,2259.5
#position:JUN:3480.5,1402.5
$JUN:true
#position:AP_1_complex_cell:3411.5,1657
$AP_1_complex_cell:(((E | MAPK8_14_complex) & JUN) & FOS)
JUN -> AP_1_complex_cell
FOS -> AP_1_complex_cell
E -> AP_1_complex_cell
MAPK8_14_complex -> AP_1_complex_cell
#position:FOS:3610.5,1412.5
$FOS:true
#position:E:3136.5,1425.5
#position:MAPK8_14_complex:2861.5,1125.5
$MAPK8_14_complex:(((TBK1 | MAP3K7) & MAPK14) & MAPK8)
MAPK14 -> MAPK8_14_complex
MAPK8 -> MAPK8_14_complex
TBK1 -> MAPK8_14_complex
MAP3K7 -> MAPK8_14_complex
#position:MAPK14:2549.5,1247.5
$MAPK14:true
#position:MAPK8:2588,1335
$MAPK8:true
#position:TBK1:4206.833333333335,961.9285714285716
$TBK1:((IKBKE | STING1_ubiquitinated) | MAVS)
IKBKE -> TBK1
STING1_ubiquitinated -> TBK1
MAVS -> TBK1
#position:MAP3K7:2985.5,1002.5
$MAP3K7:TRAF6_ubiquitinated
TRAF6_ubiquitinated -> MAP3K7
#position:IKBKE:4255.5,1114.5
$IKBKE:((TBK1 | MAVS) & !Nsp3)
Nsp3 -| IKBKE
TBK1 -> IKBKE
MAVS -> IKBKE
#position:STING1_ubiquitinated:4920.653846153846,1516.2692307692307
$STING1_ubiquitinated:(MAVS & !pp1ab)
MAVS -> STING1_ubiquitinated
pp1ab -| STING1_ubiquitinated
#position:MAVS:4826,1894.5
$MAVS:((RIG1_MDA5_complex & !Orf9b) & !ITCH)
RIG1_MDA5_complex -> MAVS
Orf9b -| MAVS
ITCH -| MAVS
#position:TRAF6_ubiquitinated:3090.5,862.5
$TRAF6_ubiquitinated:((MYD88_TCAM1_complex & !Nsp3) & !ITCH)
MYD88_TCAM1_complex -> TRAF6_ubiquitinated
Nsp3 -| TRAF6_ubiquitinated
ITCH -| TRAF6_ubiquitinated
#position:Nsp3:3701.5,1100.5
$Nsp3:!GRL0617_drug
GRL0617_drug -| Nsp3
#position:pp1ab:5057.5,1115.5
#position:RIG1_MDA5_complex:5522.5,1697.5
$RIG1_MDA5_complex:(((((DDX58_ubiquitinated & IFIH1) & Viral_replication_phenotype) & !N) & !Nsp15) & !M)
DDX58_ubiquitinated -> RIG1_MDA5_complex
IFIH1 -> RIG1_MDA5_complex
N -| RIG1_MDA5_complex
Nsp15 -| RIG1_MDA5_complex
M -| RIG1_MDA5_complex
Viral_replication_phenotype -> RIG1_MDA5_complex
#position:Orf9b:5128,2060.5
#position:ITCH:4829,2152.5
$ITCH:Orf9b
Orf9b -> ITCH
#position:MYD88_TCAM1_complex:3260.5,672
$MYD88_TCAM1_complex:(((TREML4 | TLR7) & MYD88) & TCAM1)
MYD88 -> MYD88_TCAM1_complex
TCAM1 -> MYD88_TCAM1_complex
TREML4 -> MYD88_TCAM1_complex
TLR7 -> MYD88_TCAM1_complex
#position:RELA:3128.6363636363635,1987.5909090909092
$RELA:true
#position:p50_p65_complex_cell:3383.75,1826
$p50_p65_complex_cell:((((IKK_complex | TBK1) & RELA) & NFKB1_cell) & !N)
RELA -> p50_p65_complex_cell
NFKB1_cell -> p50_p65_complex_cell
IKK_complex -> p50_p65_complex_cell
TBK1 -> p50_p65_complex_cell
N -| p50_p65_complex_cell
#position:NFKB1_cell:2462.4999999999995,1905.1428571428569
$NFKB1_cell:NFKB_NFKBIA_complex
NFKB_NFKBIA_complex -> NFKB1_cell
#position:IKK_complex:2842.666666666667,1424.1666666666667
$IKK_complex:((TRAF6_ubiquitinated | RIPK1) & !M)
TRAF6_ubiquitinated -> IKK_complex
RIPK1 -> IKK_complex
M -| IKK_complex
#position:N:5694.264646171909,1268.5019629820088
#position:NFKB_NFKBIA_complex:2735.7142857142853,1836.142857142857
$NFKB_NFKBIA_complex:((((((((Nsp1 | S) | E) | Orf7a) | Orf3a) | N) & NFKB1_cell) & NFKBIA) & !IKK_complex)
NFKB1_cell -> NFKB_NFKBIA_complex
NFKBIA -> NFKB_NFKBIA_complex
Nsp1 -> NFKB_NFKBIA_complex
S -> NFKB_NFKBIA_complex
E -> NFKB_NFKBIA_complex
Orf7a -> NFKB_NFKBIA_complex
IKK_complex -| NFKB_NFKBIA_complex
Orf3a -> NFKB_NFKBIA_complex
N -> NFKB_NFKBIA_complex
#position:RIPK1:3760,1337.5
$RIPK1:((MYD88_TCAM1_complex | MAVS) | TCAM1)
MYD88_TCAM1_complex -> RIPK1
MAVS -> RIPK1
TCAM1 -> RIPK1
#position:M:2539.0235610428326,1487.9528779143347
#position:NFKBIA:3053.357142857142,1864.5714285714284
$NFKBIA:NFKB_NFKBIA_complex
NFKB_NFKBIA_complex -> NFKBIA
#position:Nsp1:2896.5,1754.5
#position:S:2757.5,1710
#position:Orf7a:2467.857142857142,2061.5714285714284
#position:Orf3a:2465.857142857142,1983.5714285714284
#position:TCAM1:3600,542.5
$TCAM1:true
#position:MYD88:3340.5,527.5
$MYD88:true
#position:TLR7:3102.5,402.5
$TLR7:PAMP_signalling_phenotype
PAMP_signalling_phenotype -> TLR7
#position:GRL0617_drug:3540.220252684262,816.2911560508154
#position:DDX58_ubiquitinated:5908.863636363636,1699.1363636363635
$DDX58_ubiquitinated:((TRIM25 | RNF135) & !N)
N -| DDX58_ubiquitinated
TRIM25 -> DDX58_ubiquitinated
RNF135 -> DDX58_ubiquitinated
#position:IFIH1:5908.863636363636,1791.1363636363635
$IFIH1:!Nsp15
Nsp15 -| IFIH1
#position:Nsp15:1053.5,1842
#position:Viral_replication_phenotype:5512.5854730708825,1569.0882193432028
#position:OAS1_rna:1112.5,2828.5
$OAS1_rna:(ISRE_complex & IRF3_nucleus)
ISRE_complex -> OAS1_rna
IRF3_nucleus -> OAS1_rna
#position:IRF3_nucleus:1324,3103.5
$IRF3_nucleus:IRF3_cell
IRF3_cell -> IRF3_nucleus
#position:OAS1_cell:518.045454545454,2083.181818181818
$OAS1_cell:OAS1_rna
OAS1_rna -> OAS1_cell
#position:OAS1_cell_active:726.363636363636,2083.181818181818
$OAS1_cell_active:(OAS1_cell & !Nsp15)
OAS1_cell -> OAS1_cell_active
Nsp15 -| OAS1_cell_active
#position:OAS1_EIF2AK_complex:522,2261
$OAS1_EIF2AK_complex:(((OAS1_cell_active & OAS3_cell_active) & EIF2AK) & OAS2_cell_active)
OAS1_cell_active -> OAS1_EIF2AK_complex
OAS3_cell_active -> OAS1_EIF2AK_complex
EIF2AK -> OAS1_EIF2AK_complex
OAS2_cell_active -> OAS1_EIF2AK_complex
#position:OAS3_cell_active:835,1913.181818181818
$OAS3_cell_active:(OAS3_cell & !Nsp15)
OAS3_cell -> OAS3_cell_active
Nsp15 -| OAS3_cell_active
#position:EIF2AK:1180.363636363636,2087.3333333333335
$EIF2AK:(EIF2AK_rna | (EIF2AK & !Nsp15))
EIF2AK_rna -> EIF2AK
EIF2AK -> EIF2AK
Nsp15 -| EIF2AK
#position:OAS2_cell_active:782,1998.181818181818
$OAS2_cell_active:(OAS2_cell & !Nsp15)
OAS2_cell -> OAS2_cell_active
Nsp15 -| OAS2_cell_active
#position:OAS3_cell:518.045454545454,1913.181818181818
$OAS3_cell:OAS3_rna
OAS3_rna -> OAS3_cell
#position:EIF2AK_rna:1759.5,2858.5
$EIF2AK_rna:(ISRE_complex & IRF3_nucleus)
ISRE_complex -> EIF2AK_rna
IRF3_nucleus -> EIF2AK_rna
#position:OAS2_cell:517.5,1997.5
$OAS2_cell:OAS2_rna
OAS2_rna -> OAS2_cell
#position:OAS3_rna:577.5,2828.5
$OAS3_rna:(ISRE_complex & IRF3_nucleus)
ISRE_complex -> OAS3_rna
IRF3_nucleus -> OAS3_rna
#position:OAS2_rna:852.5,2828.5
$OAS2_rna:(ISRE_complex & IRF3_nucleus)
ISRE_complex -> OAS2_rna
IRF3_nucleus -> OAS2_rna
#position:IRF3_cell:4605,1291.5
$IRF3_cell:((((((((TBK1_IKBKE_complex | TRAF3_TBK1_IKBKE_complex_cell_active) | TBK1) | MAVS) & !Nsp3) & !N) & !Orf8_complex) & !Orf6) & !pp1ab)
TBK1_IKBKE_complex -> IRF3_cell
Nsp3 -| IRF3_cell
N -| IRF3_cell
TRAF3_TBK1_IKBKE_complex_cell_active -> IRF3_cell
Orf8_complex -| IRF3_cell
TBK1 -> IRF3_cell
Orf6 -| IRF3_cell
pp1ab -| IRF3_cell
MAVS -> IRF3_cell
#position:TBK1_IKBKE_complex:4618,930
$TBK1_IKBKE_complex:((((((Nsp13 | TRAF3) | TRAF3_TANK_TBK1_IKKepsilon_complex) | MAVS) & TBK1) & IKBKE) & !Nsp3)
TBK1 -> TBK1_IKBKE_complex
IKBKE -> TBK1_IKBKE_complex
Nsp13 -> TBK1_IKBKE_complex
TRAF3 -> TBK1_IKBKE_complex
Nsp3 -| TBK1_IKBKE_complex
TRAF3_TANK_TBK1_IKKepsilon_complex -> TBK1_IKBKE_complex
MAVS -> TBK1_IKBKE_complex
#position:Nsp13:4433,910
#position:TRAF3:3951.5,856.3333333333334
$TRAF3:(MYD88_TCAM1_complex & !Nsp3)
MYD88_TCAM1_complex -> TRAF3
Nsp3 -| TRAF3
#position:TRAF3_TANK_TBK1_IKKepsilon_complex:4433.85065814576,461.5315066111257
$TRAF3_TANK_TBK1_IKKepsilon_complex:((TRAF3_TBK1_IKBKE_complex_cell_active & TANK) & !M)
TRAF3_TBK1_IKBKE_complex_cell_active -> TRAF3_TANK_TBK1_IKKepsilon_complex
TANK -> TRAF3_TANK_TBK1_IKKepsilon_complex
M -| TRAF3_TANK_TBK1_IKKepsilon_complex
#position:TRAF3_TBK1_IKBKE_complex_cell_active:5482.954545454544,875.4545454545453
$TRAF3_TBK1_IKBKE_complex_cell_active:((TRAF3_TBK1_IKBKE_complex_cell & STING1_ubiquitinated) & !pp1ab)
TRAF3_TBK1_IKBKE_complex_cell -> TRAF3_TBK1_IKBKE_complex_cell_active
STING1_ubiquitinated -> TRAF3_TBK1_IKBKE_complex_cell_active
pp1ab -| TRAF3_TBK1_IKBKE_complex_cell_active
#position:TANK:5513,784.5
$TANK:true
#position:TRAF3_TBK1_IKBKE_complex_cell:4998.5,874.5
$TRAF3_TBK1_IKBKE_complex_cell:((TBK1_IKBKE_complex & TRAF3) & !pp1ab)
TBK1_IKBKE_complex -> TRAF3_TBK1_IKBKE_complex_cell
TRAF3 -> TRAF3_TBK1_IKBKE_complex_cell
pp1ab -| TRAF3_TBK1_IKBKE_complex_cell
#position:PAMP_signalling_phenotype:3169.5,118.5
#position:TRIM25:6125,1561.5
$TRIM25:true
#position:RNF135:6246,1560.5
$RNF135:true
#position:NLRP3_inflammasome_complex:2691.5,2325.5
$NLRP3_inflammasome_complex:(E | p50_p65_complex_nucleus)
E -> NLRP3_inflammasome_complex
p50_p65_complex_nucleus -> NLRP3_inflammasome_complex
#position:Orf8_complex:4269.5,1382
#position:Immune_Response_phenotype:1918.5,3411.5
$Immune_Response_phenotype:((((IRF3_nucleus | p50_p65_complex_nucleus) | IRF7_nucleus) | OAS1_EIF2AK_complex) & !Nsp3)
IRF3_nucleus -> Immune_Response_phenotype
p50_p65_complex_nucleus -> Immune_Response_phenotype
IRF7_nucleus -> Immune_Response_phenotype
OAS1_EIF2AK_complex -> Immune_Response_phenotype
Nsp3 -| Immune_Response_phenotype
#position:IRF7_nucleus:4291.5,3019.5
$IRF7_nucleus:IRF7_cell
IRF7_cell -> IRF7_nucleus
#position:IRF7_cell:4289,1986.5
$IRF7_cell:TBK1_IKBKE_complex
TBK1_IKBKE_complex -> IRF7_cell
#position:Inflammation_phenotype:3277,3325
$Inflammation_phenotype:(p50_p65_complex_nucleus | NLRP3_inflammasome_complex)
p50_p65_complex_nucleus -> Inflammation_phenotype
NLRP3_inflammasome_complex -> Inflammation_phenotype