https://calla.rnet.missouri.edu/cheng_courses/mlbioinfo/eddy_profile_hmm.pdf
https://www.cs.tau.ac.il/~rshamir/algmb/00/scribe00/html/lec06/node1.html
R packages:
https://www.rdocumentation.org/packages/aphid/versions/1.3.5
https://cran.r-project.org/web/packages/HMM/index.html
Slides: