Social cognition in schizophrenia Contemporary topics in cognitive neuroscience FSS Martin Jáni martinjani@mail.muni.cz Výsledok vyhľadávania obrázkov pre dopyt ww2 plane fight photo About me Outline •Schizophrenia •Social cognition •Networks •Self • Súvisiaci obrázok https://www.news-medical.net/image.axd?picture=2017%2F10%2Fshutterstock_326738381.jpg https://pbs.twimg.com/media/C3r6b3eWEAEFyAE.jpg http://images.slideplayer.com/34/10173824/slides/slide_4.jpg https://img.memecdn.com/emo-forever-alone_o_255284.jpg http://ars.els-cdn.com/content/image/1-s2.0-S0924933807013119-gr1.jpg Schizophrenia =/= psychosis https://www.researchgate.net/profile/Nitin_Gogtay/publication/5939278/figure/fig1/AS:20292950927769 6@1425393573181/Comparison-of-the-Patterns-of-Cortical-Gray-Matter-GM-Loss-in-Childhood-Onset.png http://www.schizophrenia.com/research/thompson.images_files/1_PERC_comp_6PANELS_SMALL.gif http://ib.bioninja.com.au/_Media/neural-pruning_med.jpeg https://image.slidesharecdn.com/negativesymptomsme-150907180322-lva1-app6891/95/negative-symptoms-o f-schizophrenia-35-638.jpg?cb=1441649152 http://images.the-scientist.com/content/figures/images/yr2003/nov03/genes.gif Gottesman 2001 Cognition as endophenotype https://openi.nlm.nih.gov/imgs/512/205/3367402/PMC3367402_dddt-6-107f1.png Functional outcome Social cognition General cognition Výsledok vyhľadávania obrázkov pre dopyt happy woman sweaters Súvisiaci obrázok Výsledok vyhľadávania obrázkov pre dopyt perspective taking Výsledok vyhľadávania obrázkov pre dopyt emo alone Social cognition / isolation Výsledok vyhľadávania obrázkov pre dopyt faces in things Výsledok vyhľadávania obrázkov pre dopyt faces in things Výsledok vyhľadávania obrázkov pre dopyt faces in things https://jamanetwork.com/data/Journals/PSYCH/5147/yoa01051f2.png Fusiform gyrus GM volume reduction The fusiform gyrus region of interest on a 3-dimensional reconstruction of the ventral surface of the brain (A) and on a coronal slice (B). L indicates left; R, right. Face identification Lee et al. 2002 Face detection Age/sex identification Identity discrimination Výsledok vyhľadávania obrázkov pre dopyt people vintage https://monoskop.org/images/thumb/3/3d/JE_Purkyne_Faces_1869.jpg/250px-JE_Purkyne_Faces_1869.jpg Facial emotion recognition Súvisiaci obrázok positive / negative emotion specific emotions neutral faces misattribution role of context http://www.epresov.com/files/fotogaleria/4999.jpg How does the person feel? http://www.epresov.com/files/fotogaleria/4999.jpg https://www.youtube.com/watch?v=LUN2YN0bOi8 Theory of mind https://humannaturegroup.files.wordpress.com/2010/12/10744-22.jpg https://vimeo.com/51243376 https://www.youtube.com/watch?v=f8TFi6qvPbc Animated shapes http://journals.plos.org/plosone/article/figure/image?size=large&id=info:doi/10.1371/journal.pone.0 019971.g005 http://journals.plos.org/plosone/article/figure/image?size=large&id=info:doi/10.1371/journal.pone.0 019971.g006 Kim et al. 2011 Schurz et al. 2013 https://ars.els-cdn.com/content/image/1-s2.0-S0149763414000128-gr2.jpg Kronbichler et al. 2017 Schizophrenia vs healthy group https://upload.wikimedia.org/wikipedia/commons/9/9a/Default_mode_network-WRNMMC.jpg Default mode / task negative network (Raichle et al. 2001) master.img-000.jpg Autobiographical memory Navigation Theory of Mind Default mode Prospective thinking Spreng et al. 2008 https://www.frontiersin.org/files/Articles/80012/fnbeh-08-00171-HTML/image_m/fnbeh-08-00171-g002.jp g Nekovarova et al. 2014 Self Minimal self / ipseity Autobiographical self Internal vs external stimuli Self monitoring Sense of agency Anomalous self experience Výsledok vyhľadávania obrázkov pre dopyt depersonalization thank you for your attention Literature Gottesman II, Erlenmeyer-Kimling L. Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early-interventions in schizophrenia. Schizophr Res [Internet]. 2001 Aug 1;51(1):93–102. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11479071 Jáni M, Kašpárek T. Emotion recognition and theory of mind in schizophrenia: A meta-analysis of neuroimaging studies. World J Biol Psychiatry [Internet]. 2017 May 30;1–11. Available from: https://www.tandfonline.com/doi/full/10.1080/15622975.2017.1324176 Kim J, Park S, Blake R. Perception of Biological Motion in Schizophrenia and Healthy Individuals: A Behavioral and fMRI Study. Op de Beeck HP, editor. PLoS One [Internet]. 2011 May 20;6(5):e19971. Available from: http://dx.plos.org/10.1371/journal.pone.0019971 Lee CU, Shenton ME, Salisbury DF, Kasai K, Onitsuka T, Dickey CC, et al. Fusiform gyrus volume reduction in first-episode schizophrenia: a magnetic resonance imaging study. Arch Gen Psychiatry [Internet]. 2002 Sep;59(9):775–81. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12215076 Nekovarova T, Fajnerova I, Horacek J, Spaniel F. Bridging disparate symptoms of schizophrenia: a triple network dysfunction theory. Front Behav Neurosci [Internet]. 2014 May 30;8:171. Available from: http://journal.frontiersin.org/article/10.3389/fnbeh.2014.00171/abstract Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A [Internet]. 2001 Jan 16;98(2):676–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11209064 Shamay-Tsoory SG, Aharon-Peretz J, Levkovitz Y. The neuroanatomical basis of affective mentalizing in schizophrenia: comparison of patients with schizophrenia and patients with localized prefrontal lesions. Schizophr Res [Internet]. 2007 Feb;90(1–3):274–83. Available from: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846614078&partnerID=tZOtx3y1 Schurz M, Radua J, Aichhorn M, Richlan F, Perner J. Fractionating theory of mind: A meta-analysis of functional brain imaging studies. Neurosci Biobehav Rev [Internet]. 2014;42(0):9–34. Available from: http://www.sciencedirect.com/science/article/pii/S0149763414000128 Spreng RN, Mar R a, Kim ASN. The Common Neural Basis of Autobiographical Memory, Prospection, Navigation, Theory of Mind, and the Default Mode: A Quantitative Meta-analysis. J Cogn Neurosci [Internet]. 2009 Mar;21(3):489–510. Available from: http://www.mitpressjournals.org/doi/10.1162/jocn.2008.21029 Thompson PM, Vidal C, Giedd JN, Gochman P, Blumenthal J, Nicolson R, et al. Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia. Proc Natl Acad Sci U S A [Internet]. 2001 Sep 25;98(20):11650–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11573002