Syntéza hernu
© Biochemický ústav LF MU (V.P.)
Synthesis of haem
© Department of Biochemistry (V.P.), Faculty of Medicine, MU Brno 2009
sukc'mvl succinyl
S
CoA CcA
COOH
CHy
amino levu/ova by*.
v^—keio-vale ro va
of- amino lfa)evulmic acid
y-keto valeric
COOH
COOH I
C- 2 H20 porŕobil'moaen
CH
I
CH*
C\H^OfC
/
p c rphobiľmoQeh
N
pyrroi
Porfo bilino^en Porphobilinogen
COOH I
CH*
spojenípvrrolovvch
' kruhu
pyrrole rinQS linked "together
(óy) methinle - CH=+CHX
or]rPetv/en/e-Cr/j- f\"]\
CH^ -—
\
octom &ys, acetic acid
\
methyl
N-H
C 00 H I
OH**
i 1
CH,
/
'COQH
V
/
0)
propionova. propionic acid
arninolevuloYcĹ mmina struktury) I
(v závorce struktura.)
PGR FY R!N J G£MY,
uroporfyrino^en
kopro po rfyrinogen ™~
I /- Cf% C Hz ÍČOtiM -2CC2 %
pro bo po r*ŕyrin oger*
-pOKFVRIA/y
uro porŕyrťn
-CHz-CHfCOOHJ^
kopro porfyrin
'ch*
-CHz-CHt-eOON}^
-CHZ-
ro-RFiN
ČW3 -éetra --CH = CHX di-CHrCHt-COOH dí-
>ro t oporfyrín ^1 S, 5^ S —
&t% -
o