Drug forms in stomatological practise
1.Mucoadhesive pastes
2.Solutions, suspensions, mucilages, gels
3.Ointments, pastes
4.Oral globules
5.

1. mucoadhesive pastes
•Adjuvant: swelling substance disperged in lipophilic base
–hypromellose in vaseline and/or liquid paraffine
•Active compound:
–Local anaesthetic
•benzocain, lidocain
–Epithelisants
•dexpanthenol, tocopherol-alpha-acetate
–Corticosteroids
•hydrocortisone, triamcinolon-acetonide, betamethason-dipropionate, fluocinolon-acetonide
•

MAP with 10% of benzocain and 5% of dexpanthenol
•Rp.
–Benzocaini   1,0
–Dexpanthenoli                                       0,5
–Hypromellosi                                         2,4
–Vaselini albi                                           2,0
–Menthae piper. etherol. gutt. II (duas)
–Paraff. liq.                                       ad 10,0
–M. f. pasta mucoadhes.
–D.S. Apply 4-6x per day after meal on afflicted area.
INDICATION: decubites, stomatitis herpetica localised on hard palate or gum

MAP with 5% of dexpanthenol
•Rp.
–Dexpanthenoli                 0,5
–Hypromellosi                   3,0
–Menthae piper. etherol. gutt. II (duas)
–Vaselini albi                     2,0
–Paraff. liq.                  ad 10,0
–M. f. pasta mucoadhes.
–D.S. Apply several times a day after meal on affected area.
INDICATION: healing dressing – after minor injuries, surgeries

MAP with 0,1% of dexamethason
•Rp.
–Dexamethasoni                 0,01
–Hypromellosi                      4,0
–Menthae piper. etherol. gutt. II (duas)
–Vaselini albi                        2,0
–Paraff. liq.                     ad 10,0
–M. f. pasta mucoadhes.
–D.S. Apply 4-6x per day after meal on afflicted area.
INDICATION: treatment of autoimmune disorders affecting mucouse or mucositis after
immunosuppressant therapy

2. Solutions, suspensions, mucilages, gels
•Suitable for surface disorder of mucous tissue:
–Of mycotic ethiology (Candida):
•nystatin
•boraxglycerol
–Of viral ethiology (HSV):
•Zinc oxide
•Zinc sulphate (0,02 – 2%; usually 0,25%)
•chlorhexidine (0,1 – 2%;usually 0,12%)
–Bacterial infections
•Gentian violet, hydrogen peroxide
•Chronic gingivitis
–adstringents

Izotonic suspension of nystatin
•Rp.
–Nystatini (6500 IU/mg)           0,3
–Hypromellosi                         0,12
–Glyceroli 85%                         0,6
–Menthae piper. etherol.     gutt. II (duas)
–Aq. conserv.                    ad 20,0
–M. f. susp.
–D. ad vitr. gutt.
–S. 6x day 1ml (20 drops) of suspension, dissolve in mouth; do not drink or rinse mouth for at
least 10min.
INDICATION : mucosal candidosis (prevention: 3xday 0,5ml; therapy: 6xday 1,0 ml)

Nystatin suspension
•Rp.
–Nystatini          2 mil UI
–Methylcellulosi        0,3
–Glyceroli  85%         0,6
–Aquae purif.      ad 20,0
–D.S. suspension for oral mucosa, apply 4x day
•

Boraxglycerol (boraxglycerine) 4%
•Rp.
• Natrii tetraboratis decahydrici 2,0
• Glyceroli 85%     ad 50,0
• M.f.liquid.
• D.S. for spreading on oral mucose, 3x day.
•
INDICATION: candidosis

Chlorhexidine gel 1%
•Rp.
–Chlorhexid. digluc. sol. 20%       5,0
–Glyceroli 85%                             8,0
–Methylcellulosi                            3,6
–Menthae piper. etherol.              0,4
–Aq. purif.                            ad 100,0
–M. f. gelat.
–D.S. Pro ordinatione.
–
INDICATION: into interdental spaces; gingivitis, parodontitis, aphtae, healing of wounds,
prevention in risk of Streptococcus mutans colonisation.

Gentian violet 2%
•Rp.
–Methylrosanilinii chloridi 1,0
–Ethanoli 60% 5,0
–Glyceroli 85% 5,0
–Aquae purificatae   ad 50,0
–M. f. sol.
–S. For spreading on oral mucose several times a day
INDICATION: stomatitis aphtosa

Hydrogen peroxide 6%
•For local treatment of gums
• (Pro ordinatione.)
•Diluted 1:1 in water
•
INDICATION: gingivitis ulcerosa - anaerobic microbes of subgingival plaque

Hydrogen peroxide 6%
•
•Rp.
• Hydrogenii peroxidi 30%       50,0
• Aquae purificatae           ad 250,0
• M.f.liq.
• D.ad lag. fusc.
• S. 1 spoon into glass of water, rinse mouth several times a day.
INDICATION: gingivitis ulcerosa - anaerobic microbes of subgingival plaque

Adstringent solution with menthol
•Rp.
–Levomentholi                              0,2
–Aluminii acetotartratis sol.        40,0
–Aq. purif.                                   20,0
–Ethanoli 60%                      ad 100,0
–M. f. sol.
–D.S. use,3xday, dilute 1 spoon into glass of warm water, rinse the mouth.
INDICATION: chronic gingivitis

Decoctions - phytopharmacs
•salvia (Salviae officinalis folium); chamomilla (Chamomillae romanae flos) or agrimony (Agrimoniae
herba)
•
•Rp.
–Salviae officinalis folii 50,0
–D.S. use 1 spoon of the herb to prepare 1 cup of brew for rinsing the mouth.
INDICATION: gingivitis chronica

Artificial saliva
•Rp.
• Carmellosi natrici          1,0
• Aquae purificatae ad 200,0
• M.f.liquid.
• D.S. For rinsing the mouth between meals.
•

Artificial saliva
•Rp.
–Methylcellulosi                  1,0
–Glyceroli 85%                    9,0
–Natrii chloridi                     0,7
–Aq. purif.                   ad 100,0
–M. f. sol.
–D.S. For rinsing the mouth between meals.

3. ointments, pastes
•Extraoral treatment – oleophilic ointments
–Lips (cheilitis, ragades)
–Facial skin
–
•Oral treatment
–hydrophilic ointments (macrogoles)
–emulsifying ointments o/w
•

Hydrophilic ointment with corticoid 0,1%
•Rp.
–Dexamethasoni        0,01
–Paraffini liq.             q.s.
–Ung. macrogoli   ad 10,0
–M.f.ung.
–D.S. 3 x day apply on oral mucose.
•

Hydrophilic ointment with 20% of benzocaine
•Rp.
–Benzocaini                                     4,0
–Aurantii dulc. peric. etherol.  gutt. IV (quattor)
–Saccharini natrici                          0,04
–Macrogoli 300                              10,0
–Macrogoli 4000                              6,0
–M. f. ung.
–S. Pro ordinatione.
•
INDICATION: before injection of LA, removal of calculus, for children

Hydrophobic ointment with salicylic acid 2%
•Rp.
–Acidi salicylici        0,4
–Zinci oxidi unguenti ad 20,0
–M.f.ung.
–D.S. Ointment of corner of lips, apply several times a day.
–
INDICATION: stomatitis angularis, Candida albicans, HSV, allergies, deficiency of B2

4. oral globules
•Gelatinous globules for dissolving in mouth
•Therapy of xerostomia
–Decreased salivation (by PSL, anti H1, diuretics, tranquillisers, radiotherapy)
–therapy: PS-mimetics, solutions of 0,5% carmellose
•

Pilocarpine oral globules
•Rp.
–Pilocarpini hydrochloridi 0,002
–Gelatinae 0,72
–Glyceroli 85%                2,0
–Ac. citrici                          0,04
–Aq. conservantis                  q.s.
–M. f. globul. oral.
–D. t. d. No. XXX (triginta)
–S. 3xday suck 1 globule when needed.

Systemic treatment of salivation impair - capsules
•xerostomia: pilocarpine hydrochlorid (DTS 0,005g)
•
•Rp.
–Pilocarpini hydrochloridi    0,15
–Lactosi monohydrici   q.s.
–M. f. pulv.
–Div. in dos. aeq. No XXX (triginta)
–D. ad caps. gelat.
–S. 3x day 1 capsule.

Systemic treatment of salivation impair - capsules
•ptyalism (sialorrhea) in stomatitis, irritation of oral mucosa, injury of jaw, Parkinson disease,
heavy metal intoxication, psychiatric disorders
•atropin sulphate monohydrate (DTS 0,0005g)
•
•Rp.
– Atropini sulfatis monohydrici 0,0005
– Lactosi monohydrici q.s.
– M. f. pulv.
– D.t.d. No XXX (triginta)
– Ad caps.gelat.
– S. 3x day 1 capsule