Rain drops 02
External liquid drug dosage forms
Jana Kučerová

Liquida (Liquids)
•
• – true (ionic and molecular dispersions)
• – colloids
§application: p.o., inj., external
§High bioavailability
§solvents:
–Aqua purificata, A. pro iniectione, A. conservans
–Ethanolum 60 %, 85 %, 96 %
–Helianthi oleum raffinatum
–Glycerolum 85 %

§Tinctura ad usum alium (Liquids for other use)
§Dispersions designated to be administered on the skin, mucoses, for irrigations or nose or ear
instillation
–
§Dispresions for compress or application on the skin – liquid preparation used namely in
dermatology
§Water based liquids
§antiseptic, antibacterial and antiflogistic effects (Solutio Jarish, Kalii permanganas)
§adstringents (containing Tannin, Argenti nitras; Aluminii acetotartratis solutio)

•Solutio Jarish
•
• Rp. Acidi borici 20,0
• Glycerini 40,0
• Aq. purif.   ad 1000,0
• M. f. sol.
• D. ad vitr.
• S. for compressions
•
•
• Rp. Solutionis Jarish 1000,0
• D.S. for compressions

§spirit solutions – antiseptics (Solutio iodi ethanolica, salicylic spirit…)
§
•Rp. Acidi salicylici          2,0
• Ethanoli 60% ad 100,0
• M. f. sol.
• D.S. …
•

•Solutio Novikov
§
• Rp. Viridis brillantis 0,2
• Ethanoli 85% 0,2
• Tannini 0,5
• Ricini olei virginalis 1,0
• Collodii elastici P.P.      ad 20,0
• M. D. S. Solutio Novikov. Ad usum medici.

P.P. = dle Praescriptiones Pharmaceuticae

§Antiseptic solution:
§Oficinal solution of  hydrogen peroxide 3%
•
– Rp. Hydrogenii peroxidi 3% 100,0
»D. ad vitr. fusc.
»S. Suo nomine.
–
§0,1% solution of resorcinol
• Rp. Resorcinoli 1,0
– Aquae purificatae ad 1000,0
– M. f. sol.
– D. ad vitr.
– S. for compressions

–Pulveres adspersorii liquidi (Liquid powders)
§semiliquid suspensions
§effects: cooling, antiitching, drying, antiseptic
§solid phase: Zinci oxidum + Talcum (1:1)
§liquid phase (60 – 70 %):
§Glycerolum 85 %
§Aqua purificata
§Ethanolum 60 %
§Bentoniti magma (5 %)
§Silica coloidalis anhydrica (3 – 5 %)

•Antitching liquid powder
•
•
• Rp. Mentholi racemici 1,0
• Zinci oxidi
• Talci
• Glyceroli
• Bentoniti magmatis aa ad 100,0
• M. f. susp.
• D. S. liquid powder, shake before use

§Preparata ad irrigationem (Preparations for irrigations)
§
§sterile water based preparations for irrigation of body cavities, wounds, example: surgery

Rhinoguttae (Nasal drops)
§liquid preparation used for drop into the nose, nose irrigations or spraying with local or
systhemic effect (calcitonin, oxytocin,…)
§
§Stabilized by antimicrobial agents, isotonic and isoacid, sometimes sterilized (Sterilisetur!)
•
§Adjusted into small bottles with dropper - 10–20g
§

§Mucose decongestion:
§Ephedrini hydrochloridum (0,5-1%)
§Naphazolini nitras (0,05 - 0,1%)
–
§Antiseptic effect: Acidum boricum 3 %
§Natrii tetraboras 2 %
§Carbethopendecinii bromidum 0,02 - 0,05 %
§Argenti diacetyltannas albuminatus 4 - 6 %
–
§Vehicles: Aqua purificata, sterilisata, conservans

recept IPLP01



•Borephedrine nose drops
•
•
• Rp. Ephedrini hydrochloridi       0,2
• Acidi borici       0,6
• Aq. purif. ad 20,0
• M. f. sol.
• D. ad vitrum guttatum!
• S. Nose drops,  3´daily 1 - 2 drops.

Otoguttae (Ear drops)
§solutions, emulsions or suspensions used for drop into the ear or irrigation
§
§The same quality as nose drops
§
§Adjusted into small bottles with dropper - 10–20g
§
§(Adde guttatorium!)

§To clean the ear:
§Hydrogenii peroxidum 3%
§Paraffinum liquidum
§Glycerolum 85% + Ethanolum 96% (1:1)
§
§Inflammation of auditory canal:
§boralcohol (Ac. boricum, Ac. salicylicum a Ethanolum 96% in water)

•
• Rp. Acidi borici 0,6
• Ethacridini lactici monohydrici 0,02
• Aq. purif.       ad 20,0
• M. f. otoguttae.
• Adde guttatorium!
• D. S. Ear drops.

Oculoguttae (Eye drops)
Aquae ophthalmicae (Eye waters)
§Sterile liquid preparations used for drop into the eye or eye irrigarion
§
§Antiseptic preparation, isotonic solutions
§isoacidity and sterility need has to be part of prescription
§
§vehicle: Aqua pro iniectione
§Prescribed amount:10-20g, waters 100 g
§exspiration: 1 - 2 weeks

§antiseptcs:
§Ready made: Carbethopendecinii bromidum (Ophthalmo- Septonex®)   Benzododecinii bromidum (Ophtal®)
•
§IP:  Argenti diacetyltannas albuminatus (targesin) 2 %
– Argenti nitras 0,25 - 0,5 %
– Acidum boricum 1,65 - 1,75 %
–
–

•irrigations:
•
•
• Rp. Natrii tetraborici decahydrici 2,0
• Natrii chloridi        0,162
• Aq. pro iniectione   ad  100,0
• M. f. coll.
• Ad vitr. fusc.
• D.S. Suo nomine. Ad manus medici.

§mydriatics:
§therapeutic:
§Atropini sulfas monohydricus 0,5 - 1%
§Scopolamini hydrobromidum trihydricum 0,1-0,25%
§diagnostic:
§Homatropini hydrochloridum 1%
•
•Rp.  Homatropini hydrobromidi        0,1
•       Aquae pro iniectione            ad 10,0
•       M. f. oculoguttae
•       D. ad vitr. gutt.
•       S.  Eye drops. Sub signo veneni!

§miotics (antiglaucomatics):
§Pilocarpini hydrochloridum 1 – 3 %
§Physostigmini salicylas 0,1 - 0,25 %
–
–
–Rp.       Pilocarpini hydrochloridi        0,6
–        Physostigmini salicylatis        0,05
–        Aquae pro iniectione ad 20,0
–        M. f. oculoguttae
–        Ad vitr. gutt.
–        D. S.: Eye drops. 3x 1-2 drops to the left eye. Sub signo veneni!