Misc. ØGaseous drug dosage forms ØDoses for children ØPrescription of narcotics and psychotropic drugs Preparata gaseosa ØReady-made preparations in pressure bottle Ø ¢Gasa medicata ¢Gasa ad inhalationem ¢Aerodispersiones ¢Spumae medicatae ¢Inhalanda Gasa medicata ¢Therapeutic gases ØFor special therapeutic or diagnostic purposes ØStored in metal bottles under pressure ØSign and color band Ø ¢® Nitrogenii oxidum ® Oxygenum ¢® Carbonei dioxidum ® Nitrogenum ¢® Aer medicinalis (95% O2 + 5% CO2) Aerodispersiones ¢Aerodispersions ØGases, liquids or powders dispersed in gas (mostly air) ¢aerodisperze ¢ ¢ ¢molecular colloid macroscopic Aerodispersiones ØAerosols lFor inhalation lFor local or systhemic purpose l ØMacrodispersions (sprays – nebulae) lFor local application on skin, mucous tissue, body cavities, desinfection of air lIn pressure bottles with applicator or mechanic atomiser Aerodispersiones ØPreparata liquida nasalia pro aerodispersione ØNasal sprays Ø ØPulveres adspersorii pro aerodispersione Øpowders ¢ ØPreparata auricularia pro aerodispersione ØEar sprays Spumae medicatae ¢Therapeutic foams ØGas dispersed in liquid ØFoam is formed at the time of application Ø ØPreparatata pharmaceutica in vasis cum pressu Ølocal treatment of skin or mucose tissue ØPanthenol spray Inhalanda ¢Inhalant preparations ØLiquid or solid ØAdministered as vapors, aerosols or very fine powders Ømax. diameter of the particle: 10 mm ØNo irrritation in the lungs Ø Ø Inhalanda ØApplication: ØMechanical atomiser ØAtomiser under pressure ØInhalator for dry powder Ø ØInhalanda in vasis cum pressu doses emittentia Ø Drug dosage for children Dosage for children ØFor babies and kids up to 15 years ¢ ØReady-made – in the original box, databases ØIPLP – ČL 2002, 2005 ¢ ¢The dose depends on: ØAge ØBody weight ØBody surface ØIndividual sensibility ØHealth Dosage for children ØDose calculation based on body surface ¢ body surface m2 ¢dose = ----------------------- x dose for adults ¢ 1,73 ¢ ØBody surface of the child l 7 x age + 45 lbody surface = -------------- l 100 Dosage for children ¢Usual therapeutic doses of oficinal drugs (Table V. in ČL 2002) ØBased on body weight and surface Ø ¢Based on age: Ø0-1, 1-6, 6-15 ØInterpolation for every year ØDay dose = 3x individual dose ØOverdosage signed with exclamation: ! Dosage for children Název léčiva Způsob podání Denní dávka (g/kg) Jednotlivé dávky podle věku (g) Poznámka 0 – 1 1 – 6 6 - 15 Ampicillinum natricum p. o. 0,025 – 0,1 0,25 – 0,75 0,75 – 1,5 1,5 – 3,0 4x denně po 6hod Atropini sulfas monohyd. i. m. 0,01 – 0,02 mg 0,1 mg (do 3kg) 0,2 mg (7-9kg) 0,3 mg (12-16kg) Premedikace v anesteziologii Lactulosum p. o. 2,0 3,0 7,0 1-2x denně v závislosti na věku a indikaci Prescription of narcotics and psychotropic drugs Narcotics and psychotropic drugs ¢è Law 466/2004 Sb. about addictive substances Ørules for handling with narcotisc and psychotropic drugs and their precursors Ø ¢Table I. ČL 2002 ا§ narcotisc ا psychotropic drugs Ø(§) precursors Narcotics and psychotropic drugs ØNarcotics group I and psychotropic drugs groups II and III ØPrescriptions with a blue band l ØStandard of the form: public notice No. 34/2004 Sb. Ø ØForm are personal delivered to the physician (or person with authorization form) with serial number of the form and code of the municipal office Narcotics and psychotropic drugs ¢Blue band prescription forms: ¢ Øhave to be stored in a safe place (safe) in order to prevent theft of loss Ø Øtheft of loss has to be reported to the local municipal office and police Ø Øunfilled forms cannot be signed or stamped Ø Øin case of death of the physician, the form have to be returned to the municipal office in 10 days Narcotics and psychotropic drugs ØThe form has 2 copies § ØOnly one preparation can be prescribed to such form Narcotics ¢Group I Øopioids and other substances with high risk of development of addiction - § § Ø ¢Group II Øopioids and other substances with lower risk of development of addiction Ønormal prescriptions Øcodeine, dextropropoxyphen, ethylmorphine, folkodine Narcotics – group I §§ Alfentanyl §§ Diphenoxilate §§ Fentanyl (Durogesic) §§ Hydrocodone §§ Cocaine §§ Levorphanole §§ Methadone §§ Morphine (MST Continus) §§ Opium §§ Oxycodone (Oxycontin) §§ Oxymorphone §§ Pethidine (Dolsin) §§ Piritramide §§ Sufentanyl (Sufenta) §§ Remifentanyl §§ Tilidine Psychotropic drugs ¢group II ØPsychostimulants with high risk of development of physical addiction – amphetamine, § ¢group III ØBarbiturates with possible development of addiction - § Øamobarbitale, buprenorphine, pentobarbitale ¢group IV ØBZDs, some některé barbiturates and other substances with possible development of addiction in long term use – normal Rx Ødiazepam, oxazepam,meprobamate, phenobarbitale, methylphenobarbitale Psychotropic drigs – group III § Amphetamine § Buprenorphine (Subutex) § Dronabinole § Phencyclidine § Phenmetrazine § Flunitrazepam (Rohypnol) § Methamphetamine § Secobarbitale Precursors Øephedrine Øpseudoephedrine Øergotamine Øergometrine ¢