paleocortex, archicortex (allocortex) – neurons in 3-5 layers neocortex (isocortex) – neurons in 6 layers peripaleocortex et periarchicortex = mesocortex TELENCEPHALIC CORTEX - NOMENCLATURE Hemisfera obr32 hemdorsnew obr31 frnx%20med3 obr34 obr33 obr37 obr38 TelenCortexBar LOCATION OF MAIN FUNCTIONAL REGIONS OF TELENCEPHALIC CORTEX somatosenzory and senzory motor cortex of limbic forebrain association cortex Kopie cor4 Kopie cor4 a43 CORTICAL AREAS FOR SPEECH - I Broca‘s (motor) cortical area - g. front. inf. a44, 45 for right-hander in L-hemisphere, for left-hander in R-hemisphere Wernicke‘s (sensory) cortical area - a 22,39,40 in dominant hemi- sphere CORTICAL AREAS FOR SPEECH - II TelenCortexRec TelenFornixAmygd A SCHEMATIC DRAWING OF 3D ARRANGEMENT OF SOME TELENCEFALIC STRUCTURES obr59 obr60 obr68 BG8 Limbic system – classic conception Papez‘s circuit (James Papez 1939) without specific function ncl. anterior thalami gyrus parahippocampalis hippocampus ncl. mamillaris tr. mammilo-thalamicus fornix RECENT CONCEPTION OF LIMBIC FOREBRAIN • basomedial telencephalon, structures of diencephalon and mesencephalon for emotion and motivation of our behavior Regular structures • g. cinguli, g. parahippocampalis, hippocampus, insular cortex • area septalis, amygdalar ncll., hypothalamus (ncl. mammillaris) • neocortical regions of forebrain - basal frontotemporal regions, orbital cortex, ventral striatum (pallidum) • ncl. anterior et medialis dorsalis thalami • habenulla přední část g. parahippocampalis – entorhinální kortex – příjem kognitivních a senzorických informací z asociačních kortikálních oblastí, přenáší tyto informace do hipp. pro konsolidaci a pak vrací zpět do asociačního kortexu, kde dochází ke kodování ve formě paměťových stop hippokampální formace – subiculum, vlatní hippocampus, gyrus dentatus, jednotlivé sektory se označují jako cornu ammonis fornix – přímé pokračování fibria, která přijímají axony ze subicula a hippocampu, vedou do předního hypothalamu, ncl mammillaris bilat. poškození hippokampu – ztráta deklarativní paměti, procedurální je zachována Papez Limbic system – classic conception Papez‘s circuit (James Papez 1939) Limbic1 memory of listening to music notion of fear notion of tooth pain MDN- ncl. dorsomedialis amygdala2 amygdala AMYGDALAR NUCLEI SeptalNcl ncl. caudatus, putamen, globus pallidus, claustrum and amygdalar ncll. functional: + thalamus, substantia nigra and ncl. subthalamicus ncl. caudatus + putamen = neostriatum (striatum) globus pallidus (ext. + int. segment) = paleostriatum (pallidum) globus pallidus + putamen = ncl. lentiformis BASAL GANGLIA AND RELATED STRUCTURES Basal ganglia striatum (neostriatum) ncl. caudatus putamen ncl. accumbens dorsal striatum ventral striatum globus pallidus (pallidum, paleostriatum) med. (internal) seg. lat. (external) seg. dorsal pallidum ventral pallidum substantia nigra ncl. subthalamicus pars compacta pars reticularis BASAL GANGLIA AND RELATED STRUCTURES Kopie fig12 VENTRAL PALIDUM AND VENTRAL STRIATUM SUBSTANTIA INNOMINATA a NCL. ACCUMBENS BG2 AccumbDrogy NclAccumbDrogy WHITE MATTER OF TELENCEPHALON Pathways - associated, projection and commissural ASSOCIATED PATHWAYS - interconnections of various cortical regions fasciculus longitudinalis superior fasciculus longitudinalis inferior fasciculus uncinatus fasciculi occipitales verticales cingulum image751 fasciculus occipitofrontalis superior Projection pathways Short projection pathways Long projection pathways - capsula interna crus anterius, genu et crus posterius capsulae internae crus anterius – anterior tr. thalamo-corticalis and tr. fronto-pontinus genu - tr. cortico-nuclearis, from area 4 to contralateral motoneurons of cranial nerves crus posterius - tr. cortico-spinalis (somatotopic arrangement), tr. cortico-reticularis and tr. cortico-rubralis, posterior tr. thalamo-corticalis (somatosenzory information to parietal cortex), tr. parieto- , temporo-, occipito-pontinus, radiatio optica, radiatio acustica CAPSULA INTERNA capsula