-
- -
(A) Protoonkogeny
(A) Protoonkogeny - (A) Protoonkogeny -
cdk
Rb protein (Rb/E2F G1 checkpoint)
Protein p53 (ch. 17p13)
p53 tumor suppression
Tvorba apoptozomu a konvergence drah
MR Stratton et al. Nature 458, 719-724 (2009)
The lineage of mitotic cell divisions from the
fertilized egg to a single cell within a cancer showing
the timing of the somatic mutations acquired by the
cancer cell and the processes that contribute to
them.
LOH - Mutageny / karcinogeny
-
Angiogeneze
Abnormalit
in vitro
Invazivita
tumoru