• CNS – central nervous system •The spinal cord (medulla spinalis) • •The brain (cerebrum, encephalon) • • •Division of the brain: •The medulla oblongata(medulla oblongata) •The pons (pons Varoli) •The cerebellum (cerebellum) •The midbrain (mesencephalon) •The diencephalon (diencephalon) •The cerebrum (telencephalon) • •The brain stem= The medulla oblongata, The pons, The cerebellum, The midbrain, The diencephalon •I. Nervus olfactorius – olfactory nerve •II. Nervus opticus – optic nerve •III.Nervus oculomotorius – oculomotor nerve •IV. Nervus trochlearis – trochlear nerve •V. Nervus trigeminus – trigeminal nerve •VI. Nervus abducens – abducens nerve •VII. Nervus facialis – facial nerve •VIII. Nervus vestibulocochlearis – vestibulocochlear nerve •IX. Nervus glosopharyngeus – glossopharyngeal nerve •X. Nervus vagus – vagus nerve •XI. Nervus accesorius – accessory nerve •XII. Nervus hypoglossus – hypoglossal nerve •The cranial nerves– nervi craniales •Spinal •cord •Receptor •Thalamus •Brain stem •Sensory cortical areas •Motor cortical area •Brain stem •Muscle •Cerebellum •Analyzer •The Medulla oblongata •within foramen magnum and on clivus •Continuation of the spinal cord (20–25mm) •Extends from detachment of 1st pair of the spinal nerves (or decussatio pyramisum) till the pons • Grooves: • betwen medulla oblongata and pons – detachment of nerves (VI., VII., VIII.) • • fissura mediana anterior • • sulcus anterolateralis (XII.) • • sulcus posterolateralis (IX., X., XI.) • • sulcus medianus posterior • •The groove separate following structures •Funiculus anterior – pyramis •Funiculus lateralis - olive •Caudal: •funiculi posteriores (parts - fasciculus gracilis and cuneatus) pass into inferior peduncles of cerebellum(pedunculi cerebellares inferiores) • • •Rostral: •between divergent inferior and superior peduncles of cerebellum, medulla oblongata forms caudal part of floor of IV. brain ventricle • •Posterior side of medulla oblongata Structure of medulla oblongata: 1.Grey matter •Nuclei of cranial nerves (XII.- IX.) •reticular formation (RF): centres of vital reflexes, interconnection of particular parts of CNS, activating and inhibitory system, motion automatisms •sensory nuclei (ncl. gracilis, cuneatus) 2. White matter (contains sensory and motor pathways) •funiculus anterior (especially motor pathways e.g. pyramidal tract) •funiculus lateralis (contains e.g. Tracts to cerebellum) •funiculus posterior (contains especially sensory pathways ) •The pons (Pons Varoli) • •Transverse rampart between medulla oblongata and midbrain (lenght circa 25 mm) • •In the median plane sulcus basilaris passes (for a. basilaris) • •In the groove between pons and medulla oblongata, VI. – VIII. cranial nerves arise • •Pons passes laterally into middle peduncles of cerebellum (pedunculi cerebellares medii) • •between pons and pedunculi cerebellares medii, there is V. vranial nerve arising • • •Lateral side of the pons • •Middle peduncle (pedunculus cerebellaris medius) with output of n. V. • - especially motor pathways • • • • • • •Dorsal side of the pons • •between pedunculi cerebellares medii. There is middle part of floor of IV. brain ventricle • •Struktura pons Varoli • •1. Grey matter • • nuclei of cranial nerves (VIII. – V.) • • reticular formation (RF) • •2. White matter • •contains sensory and motor pathways (tracts of voluntary and involuntary movements) FORMATIO RETICULARIS •It belongs to the phylogenetically oldest structures of CNS •It is interconnected with all sections of CNS •Basic stereotypes (walk, sleep) •It significantly influences wakefulness, tiredness and motivation •It is located centrally and dorsally within the brain stem, especially within the pons •ascending activation system → waking from sleep, maintaining wakefulness •descending activation system •Interruption of retikulární formace →blackout •RF provides complex interconnection of cranial nerves between each other and with other areas, it provides vital reflexes since birth (blink, lachrymal, cough, sucking, salivation, swallowing…) formatio-reticularis Te midbrain (mesencephalon) • located between pons and diencephalon Ventral side of the midbrain crura cerebri – two ramparts of whote matter (motor pathways) detachment of III. cranial nerve within groove between crura cerebri anf fossa interpeduncularis •Dorsal side of the midbrain • •corpora quadrigemina •colliculi superiores (optical-motor reflexes) connection to the visual pathway • •colliculi inferiores (acoustic–motor reflexes) connection to the auditory pathway • • • •Pedunculi cerebellares superiores (superior peduncles of cerebellum) between them – roof of IV. brain ventricle • • •Detachment of IV. cranial nerve– only crania nerve that arises from dorsal side of brain stem Structure of the midbrain Three parts: 1.Tectum – corpora quadrigemina (centre of optical–motor and acoustic–motor reflexes) 2. Tegmentum – middle part- contains RF, nuclei of III. and IV. cranial nerves, nucleus ruber (red nucleus– motion control), substantia nigra (black substance – motion control) 3. Crura cerebri – anterior part, white matter, motor pathways (descending tracts – corticospinal, corticonuclear) •The midbrain (střední mozek) • source of III. and IV. cranial nerves • centre of optical–motor and acoustic–motor reflexes, its nuclei provide coordinated movements of eyes and head • • •Fossa rhomboidea •Floor of IV. brain ventricle, rhombus shaped •Nuclei of III. – XII. cranial nerves • • •parts: •1. pars superior • between pedunculi cerebellares sup. •covered with velum medullare superius • •2. pars intermedia • dorsal side of pons between • pedunculi cerebellares med. • covered with fastigium of cerebellum • • •3. pars inferior • dorsal side of medulla obl. between • pedunculi cerebellares inf. • covered with velum medullare inferius • • Fossa rhomboidea builds on: • rostrally on aquaeductus cerebri (channel between III. and IV. brain ventricle) • caudally on canalis centralis of the spinal cord • • •Spinal •cord •Receptor •Thalamus •Brain stem •Sensory cortical areas •Motor cortical area •Brain stem •Muscle •Cerebellum •Analyzer • The cerebellum •Functions: •Control of muscle tension of striated muscles, it provides upright posture, balance, it coordinates and specifies movements •Is in paralel connected into systém of motor pathways •important centre of proprioception •It provides precise coordination of •movements • • • • • • •At failure: •Muscle weaknes, unsure poise, uncoordinated walk on the wide base •Te cerebellum • • it lies within posterior cranial fossa within fossae cerebellares of occipital bone • • it touches dorsal side of brain stem • • between cerebellum and brain stem, there is IV. Brain ventricle The cerebellum is interconnected with the brain stem through three peduncles: 1.Pedunculi cerebellares superiores (with midbrain) 2. 2.Pedunculi cerebellares medii (with pons) 3. 3.Pedunculi cerebellares inferiores (with medulla oblongata) Structure of the cerebellum: 1. worm - vermis cerebelli middle part 2. cerebellar hemispheres hemisheria cerebelli (lobus anterior, lobus posterior, floculus). On the surface of vermis and hemispheres, there are notches – sulci cerebelli, which separate particular threads - gyri cerebelli Grey matter of the cerebellum: •cortex cerebelli – on the surface of hemispheres and vermis •nuclei cerebelli – nuclei withincerebellum (ncll. fastigii, ncl. emboliformis, ncl. globosus, ncl. dentatus) involved into motion control system White matter of the cerebellum : •Below the cortex, it creates characteristic drawing - arbor vitae (tree of life) Distribution of the cerebellum: 1.vestibular cerebellum (archicerebellum) •crucial for maintaining balance (information from vestibular apparatus) • influence on motor nuclei within the spinal cord, which controls ovement of axial muscles (erect posture) • control of eyey movemet and their coordination with ead movements • 2. spinal cerebellum (palaeocerebellum) •Control of muscle tension and coordination of movements – regulation of movements 3. cerebral cerebellum (neocerebellum) • control of planning of movements • control of voluntary movements in space and time •Spinal •cord •Receptor •Thalamus •Brain stem •Sensory cortical areas •Motor cortical area •Brain stem •Muscle •Cerebellum •Analyzer •The diencephalon • builds on mesencephalon • • covered with cerebral hemispheres •Distribution of diencephalon: • •Thalamencephalon (thalamus) dorsal part • • •Hypothalamus - basal part (ventral part) • • •(sulcus hypothalamicus – separates both parts) Thalamencephalon: 1.thalamus – accumulation of grey matter on dorsal side of diencephalon (ovoid shape) 2.epithalamus – e.g. pineal gland, dorsal side of diencephalon 3. metathalamus - corpus geniculatum mediale and laterale 4. subthalamus – grey matter located below thalamus 1. •THALAMUS •Accumulation of grey matter (ovoid formation) • (to its neurons come impulses from all sensory pathways except olfactory tract) • •It contains a large number of nuclei • •„gateway od consciousness“ – switching of all sensory pathways and control feedback motor pathwaysinto cerebral cortex • • •Epithalamus •dorsally at roof of III. Brain ventricle • •corpus pineale (pineal gland) – endocrine gland • • •Metathalamus • •On the posterior side of thalamus • •corpus geniculatum mediale connected with colliculus superior – part of auditory pathway • •corpus geniculatum laterale connected with colliculus inferior – part off visual pathway •Subthalamus • • grey matter located ventrocaudylly from thalamus and laterally from hypothalamus • • involved into involuntary movements Hypothalamus •Originated from motor plate •A part of hypothalamu is hypophysis Functions: •visceral brain controls aktivity of visceral organs through autonomous nerves and hormones of hypophysis (control centre of autonomous system) •It coordinates neurohumoral control (regulates functions of endocrine system) •It is essential for preservation of homeostasis •Nuclei of hypothalamus •A large number of nuclei (several groups) •Division from functional perspective: • • secretory nuclei (at wall of III. ventricle) neurosecretion – controlc aktivity of hypophysis • • nuclei that are parent to parasympathicus (anterior group) • • nuclei that are parent to sympathicus • (middle group) • nuclei affecting the instinctive and emotional behavior – serve limbic system (especially posterior group) • • •Hypophysis cerebri (pituitary gland, hypophysis) • •Endocrine gland, part of diencephalon, located at sella turcica of sphenoid bone • •Superior position to other endocrine glands • • • Hypophysis • • adenohypophysis (lobus anterior) • it produces e.g. somatotropic hormone • and hormones affecting aktivity of other endocrine glands (gonadotropci, corticotropic…) • • pars media – produces melanocyte-stimulating hormone • • neurohypophysis (lobus posterior) receives hormones • (adiuretic hormone and oxytocin) from nuclei of hypothalamus through axonal flow •