Anxiolytics and anxiety
disorders
MUDr. Vítězslav Pálenský
Dept. of Psychiatry, Masaryk University, Brno
Anxiety disorders
1. Panic disorders and agoraphobia
2. Specific phobia and social phobia
3. Obsessive - compulsive disorder
4. Posttraumatic stress disorder a nd acute stress disorder
5. Generalized anxiety disorder
1. Panic disorders and
agoraphobia
Anxiety manifests as reccurent unexpected panic attacks - discrete period of intense fear or discomfort, developed abruptly and reached a peak within 10 minutes. In some person can be associated with certain situations.
Criteria for panic attack I
1. palpitation, pounding hearth, or accelerate hearth rate
2. sweating
3. trembling or shaking
4. sesnsations of shortness of breath or smothering
5. feelikg of choking
6. chest pain or discomfort
Criteria for panic attack II
7. nausea or abdominal distress
8. feeling dizzy, unsteady, light-headed, or faint
9. derealization /feeling of unreality/, depersonalization /being detached from oneself/
10. fear of losing control or going crazy
11. fear of dying
Criteria for panic attack III
12. parestesias
13. chills or hot flushes
la/ Panic disorder without
agoraphobia
- reccurent unexpected panic attack
- at least one of the attacks has been followed by one month
- absence of agoraphobia
la/ Panic disorder without	
	agoraphobia
c.
- the panic attacks are not due to the direct physiological effects of a substance or a general medical condition
D.
- the panic attacks are not better accounted for by another mental disorder
s
lb/ Panic dissorder with
agoraphobia
Criteria A, C, D are the same as by 1/1 , difference is in B.
- the presence of agoraphobia
lb/ Panic dissorder with
agoraphobia
Criteria for agorafobia
- A. Anxiety about being in places or situations from which escape might be difficult.
- B. The situations are avoided with marked distress or anxiety about having a P.A.
- C. The anxiety or phobic avoidance are not better accounted for by another mental disorder.
1 cl Agoraphobia without history
of panic disorder
A. The presence of agoraphobia related to fear of developing panic like symptoms/dizziness or diarrhea/.
B. Criteria have never been met for panic dissorder.
C. the disturbances are not due to the direct physiological effects of a substance or a general medical condition.
Treatment
Pharmacological - SSRIs
-RIMA
- Benzodiazepines - only in emergency
Psychoterapeutic
- Cognitive-behavioral treatment /relaxation, respiratory control, exposure therapy/
2. Specific phobia and social
phobia
2a/ Specific phobia
The fear cued by the presence of a specific object or situation, such as flying, heights, animals, receiving an injection, seeing blood etc. Those must be avoided with marked distress and recognized by the person as anreasonable fear disrupting the persons life.
2b/ Social phobia
• Fear of one or more social or performance situations in which the person is exposed to unfamiliar people that will be embarassing.
Diagnostic criteria
Fear
- marked and persistant
- provoked by phobic stimulus
- recognised as unreasonable
Phobic situation
- avoided by anxiety, distress
- interferes with the persons routine, occupational, social etc. activities
Duration - at least 6 months in individuals
under age 18
Treatment
Specific phobia
- exposure therapy as the base
Social phobia
- Pharmacotherapy /RIMA, SSRIs, benzodiazepines only in emergency/
- Psychosocial /CBT/
3. Obsessive-compulsive disorder
OCD
Patient have either obsession and compulsion that are a significant source of distress
- are time - consuming
interfere significantly with the person's normal routine, occupational funcioning or social activities or relationships.
Obsessions
1. Recurrent and persistent thoughts, impulses, or images.
2. Not simply excessive worries about real life problems.
3. Attempt to ignore or supress them with some other thought or action.
4. Product of one's mind.
Compulsion
1. Repetitive behaviors in response to an obsession which must be rigidly applied.
2. Behaviors or mental act preventing or reducting distress.
- /handwashing, ordering, checking/
OCD - diagnostic criteria
A. Either obsessions or compulsions
B. At some point the person has recognised them unreasonable
C. Are time - consuming, interfere significantly with the person's normal routine, occupational functioning or social activities or relationships
D. Not restricted to other disorders.
E. Not due to direct effects of a substance or medical condition.
Treatment
Psychotherapy, behavior therapy
Pharmacotherapy - SSRIs, Li, AP
ECT
Psychosurgery
4.Posttraumatic stress
disorder(A) and acute stress disorder (B)
two of only a few disorders defined
by its cause
A. PTSD - diagnostic criteria I
A. Exposition to a traumatic event in passed /death, injury/ that the person response intense fear, helplessness, horror.
B. The traumatic event is persistently reexperienced /images, ilusions, flashbacks, dreams.../
PTSD - diagnostic criteria II
C. Three or more of the stimuli associated with the trauma
• thoughts, feelings, conversations
• activities, places, people
• inability to recall important aspects of the trauma
• markedly dimished interest in significant activities
• feeling of detachment from others
• restricted range of affects /loving feels etc./
• sense of foreshortened future /doesn't expect to have a career, marriage, children.../
PTSD - diagnostic criteria III
D. Two or more of persistant symptoms
- difficulty falling or staying asleep
- irritability or outburst of anger
- difficulty concentrating
- hyperviligance
- exaggarated startle response
PTSD - diagnostic criteria IV
E. Duration more than one month
F. The disturbance causes clinically significant distress in social, occupational or other important areas. S
B. ASD - diagnostic criteria
A. Exposition to a traumatic event in passed /death, injury/ that the person response intense fear, helplessness, horror.
B. While experiencing or after
• sense of detachment, absence emotional responsibility
• reduction in awareness of surroundings
• derealization
• depersonalization
• dissociative amnesia
ASD - diagnostic criteria II
C. The traumatic event is persistently reexperienced /images, ilusions, flashbacks, dreams.../
D. Marked symptoms of anxiety
E. Clinicallly significant distress in social, occupational or other important areas
ASD - diagnostic criteria III
F. The disturbance lasts for
- minimum two days
- maximum four veeks within the
traumatic event
G. Is not due to direct effects of a substance
or medical condition.
Treatment
Pharmacotherapy
- Antidepressants SSRIs, mood stabilizers, anxiolytics, anticonvulsants
Psychotherapy
- individual, group, relaxation training
5. Generalized anxiety disorder
GAD
Excessive anxiety or worry lasting for 6 months or longer, accompanied by at least three somatic symptoms.
GAD - diagnostic criteria I
A. Excessive anxiety and worry
B. Difficult to control it
C. Association with at least three symptoms
- feeling on edge
- being easily fatigued
- difficulty concentrating
- irritability
- muscle tension
- sleep disturbance
GAD - diagnostic criteria II
D. The focus of anxiety is not confined to features of other disorders /panic dis. Etc/.
E. The anxiety causes significant social, occupational or other distress.
F. The disturbance is not due to direct effects of a substance or a general medical condition.
Treatment
Pharmacotherapy
- Antidepressants SSRIs, BZD, beta-blockers
Psychotherapy
- dynamic, supportive, CBT
Conclusion
Anxiety disorders are common illness with considerable morbidity and social cost, accompained by anxiety, worry, distress. Half of them is undiagnosed or untreated.
References:
Waldinger RJ.: Psychiatry for medical students, Washington, DC : American Psychaitric Press, 1997
Kaplan HI, Sadock BJ, Grebb JA.: Kaplan and Sadock s synopsis of psychiatry, Baltimore: Williams and Wilkins, 1997