Refrakční vady a korekce 16.1 základní termíny Nekorigovaná a korigovaná zraková ostrost Minimum separabile- dán vzdáleností čípků 2,5um, zvětšuje se do periferie Je dán velikostí 1 minuty, což odpovídá asi 0,004mm na sítnici Refraction: Emmetropia and Ametropia Refraction is defined as the ratio of the refractive power of the lens and cornea (the refractive media) to the axial length of the globe. Emmetropia is distinguished from ametropia. Emetropie (Figs. 16. 2, 16.6a) Ametropia (refrakční vada). Může být axiální a refrakční 6.1 Basic Knowledge Tab. 16.1 Important refractive indices (n) of the various tissues of the eye Eye tissue Refractive index n Cornea 1.376 Aqueous humor 1.336 Lens at the poles 1.385 Lens at the core 1.406 Vitreous body 1.336 From Krause K. Methoden der Refraktionsbestimmung. Münster, Germany: Biermann, 1985. Very few people have refraction of exactly 0.0 diopters. Approximately 55% of persons between the ages of 20 and 30 have refraction between + 1 and – 1 diopters. Emmetropia is not necessarily identical to good visual acuity. The eye may have other disorders that reduce visual acuity, such as atrophy of the optic nerve or amblyopia. The refractive power of an optical lens system is specified in diopters, which are the international units of measure. Refractive power is calculated according to the laws of geometric optics. According to Snell’s law, the refraction of the incident light ray is determined by the angle of incidence and difference in the refractive indices n of the two media (Table 16.1). The maximum total refractive power of an emmetropic eye is 63 diopters with an axial length of the globe measuring 23.5 mm. The cornea accounts for 43 diopters and the lens for 10–20 diopters, depending on accommodation. However, the refractive power of the eye is not simply the sum of these two values. The optic media that surround the eye’s lens system and the distance between the lens and cornea render the total system more complex. The refractive power D (specified in diopters) of an optical system is the reciprocal of the focal length of a lens f (specified in meters). This yields the equation: D = 1/f. Example. Where a lens focuses parallel incident light rays 0.5 m behind the lens, the refractive power is 1/0.5 m = + 2 diopters. This is a converging lens. Where the virtual focal point is in front of the lens, the refractive power is 1/– 0.5 m = – 2 diopters. This is a diverging lens (Fig. 16.3). Accommodation The refractive power of the eye described in the previous section is not a constant value. The eye’s refractive power must alter to allow visualization of both near and distant objects with sharp contours. This accommodation is made possible by the elasticity of the lens. Accommodation mechanisms. Accommodation involves the lens, zonule fibers, and ciliary muscle. Lens. The soluble proteins of the lens are surrounded by a thin elastic capsule. The curvature of the posterior capsule of the lens is greater than its anterior curvature, with a posterior radius of 6.0 mm as opposed to an anterior radius of 10.0 mm. The intrinsic elasticity of the lens capsule tends to make the lens assume a spherical shape. However, in the unaccommodated state this is prevented by the pull of the zonule fibers. The elasticity of the inner tissue of the lens progressively decreases with age due to deposits of insoluble proteins. Zonule fibers. The radiating zonule fibers insert into the equator of the lens and connect it to the ciliary body. They hold the lens securely in position and transmit the pull of the ciliary muscle to the lens. Ciliary muscle. Contraction of the ring-shaped ciliary muscle decreases the tension in the zonule fibers. The lens can then approach the spherical shape (with a radius of curvature of 5.3 mm) that its physical configuration and chemical composition would otherwise dictate. This change in the curvature of the lens is especially pronounced in its anterior surface. The deformation increases the refractive power; the focus of the eye shifts to the near field (Fig. 16.4), and close objects take on sharp contours. As the ciliary muscle relaxes, the tension on the lens increases and the lens flattens. The resulting decrease in refractive power shifts the focus of the eye into the distance (Fig. 16.4), and distant objects take on sharp contours. The ciliary muscle is innervated by the short ciliary nerves, postganglionic parasympathetic fibers of the oculomotor nerve. Parasympatholytics such as atropine, scopolamine, and cyclopentolate inhibit the function of the ciliary muscle and therefore prevent accommodation. Referred to as cycloplegics, these medications also cause mydriasis by inhibiting the sphincter pupillae. Parasympathomimetics such as pilocarpine cause the ciliary muscle and sphincter pupillae to contract, producing miosis. 16.1 Basic Knowledge Accommodation is regulated by a control loop. The control variable is the sharpness of the retinal image. The system presumably uses the color dispersion of the retinal image to determine the direction in which accommodation should be corrected. Range of accommodation. This specifies the maximum increase in refractive power that is possible by accommodation in diopters (Fig. 16.5). In mathematical terms, the range of accommodation is obtained by subtracting near-point refractive power from far-point refractive power. The near point is shortest distance that allows focused vision; the far point describes the farthest point that is still discernible in focus. The near and far points define the range of accommodation; its specific location in space is a function of the refractive power of the eye. Example. In one patient, the near point lies at 0.1 m and the far point at 1 m. This patient’s range of accommodation is then 10 diopters – 1 diopter = 9 diopters. In an emmetropic eye, the far point is at optical infinity. However, accommodation can also bring near-field objects into focus (Fig. 16.6b). The elasticity of the lens decreases with increasing age, and the range of accommodation decreases accordingly (Fig. 16.5). Presbyopia (physiologic loss of accommo- 16.2 Examination Methods dation in advancing age) begins when the range of accommodation falls below 3 diopters. The gradual loss of accommodation causes the near point to recede; the patient’s arms become “too short for reading.” Depending on age and limitation of accommodation, presbyopia can be compensated for with converging lenses of 0.5–3 diopters (see Fig. 16.6c, d). Adaptation to Differences in Light Intensity Like a camera, the eye’s aperture and lens system also automatically adapts to differences in light intensity to avoid “overexposure.” This adjustment is effected by two mechanisms. 1. The iris acts as an aperture to control the amount of light entering the eye. This regulation takes about 1 second and can change the light intensity on the retina over a range of about a power of ten. 2. The sensitivity of the retina changes to adapt to differences in light intensity. The sensitivity of the retina to light is a function of the concentration of photopigment in the photoreceptors and of the neuronal activity of the retinal cells. The change in neuronal activity is a rapid process that takes only a few milliseconds and can alter the light sensitivity of the retina over a range of three powers of ten. The change in the concentration of photopigment takes several minutes but can cover a wide range of retinal light sensitivity, as much as eight powers of ten. 16.2 Examination Methods Visual acuity. See Chapter 1. Refraction Testing Refraction testing means measuring the additional refractive power required to produce a sharp image on the retina. Subjective and objective methods are used. Subjective methods require information from the patient. Subjective refraction testing. This consists of successively placing various combinations of lenses before the patient’s eye until the maximum visual acuity is reached (see Correction of Refractive Errors). Objectiverefractiontesting. Objective testing is unavoidable when the patient is unable to provide subjective information (for example with infants) or when this information is unreliable. This method also greatly accelerates sub- jective refractive testing. Retinoscopy (shadow testing). The retina is illuminated through the pupil. The examiner observes the optical phenomena in the patient’s pupil while moving the light source (Fig. 16.7). Refractometry. The measuring principle is based on ophthalmoscopic observation of a test image projected onto the patient’s retina. The distance between the test figure and the eye is changed until the image appears in focus on the retina. Refraction can then be calculated from the measured 16.2 Examination Methods values. An alternative to changing of the distance is to place various lenses in the path of the light beam. Automated refractometry. The method measures refraction automatically with the aid of light-sensitive detectors and a computer until a focused image appears on the retina. These systems operate with infrared light. Any objective measurements of refraction should be verified by subjective testing whenever possible. Testing the Potential Resolving Power of the Retina in the Presence of Opacified Ocular Media Special examination methods are indicated in the presence of opacification of the ocular media of the eye (such as a cataract) to determine the potential visual acuity of the retina. This permits the ophthalmologist to estimate whether optimizing the refractive media with techniques such as cataract surgery or corneal transplantation would achieve the desired improvement. Laser interference visual acuity testing. Lasers are used to project interference strips of varying widths onto the retina. The patient must specify the direction in which these increasing narrower strips are aligned. This examination can no longer be performed where there is severe opacification of the optic media such as in a mature cataract. The preliminary examination then consists of evaluating the pattern of the transilluminated retinal vasculature. Fig. 16.7 With the retinoscope, the examiner moves a light source (a beam of yellow light) across the pupil (dark spot) at a distance of about 50 cm from the patient. This produces a light reflex (red spot) in the patient’s eye. It is important to note how this light reflex (red spot) behaves as the light source in the retinoscope is moved. There are two possibilities. a Concurrent movement. The light reflex in the pupil (red spot) moves in the same direction (red arrows) as the light source of the retinoscope (yellow arrows). This means that the far point of the eye is behind the light source. b Countermovement. The light reflex in the pupil moves in the opposite direction (red arrows) to the light source of the retinoscope (yellow arrows). This means that the far point of the eye lies between the eye and the light source. The examiner places appropriate lenses in front of the patient’s eyes (plus lenses for concurrent movement and minus lenses for countermovement) until no further movement of the light reflex is observed. The movement of the retinoscope will then only elicit a brief flicker (neutral point). This method is used to determine the proper lens to correct the refractive error. 16.3 Refractive Anomalies (Table 16.2) Myopia (Shortsightedness) Definition: A discrepancy between the refractive power and axial length of the eye such that parallel incident light rays converge at a focal point anterior to the retina (Fig. 16.8a). Epidemiology. Approximately 25% of persons between the ages of 20 and 30 have refraction less than – 1 diopters. Etiology. The etiology of myopia is not clear. Familial patterns of increased incidence suggest the influence of genetic factors. Pathophysiology. Whereas parallel incident light rays converge at a focal point on the retina in emmetropic eyes, they converge at a focal point anterior to the retina in myopic eyes (Fig. 16.8a). This means that no sharply defined images appear on the retina when the patient gazes into the distance (Fig. 16.8a). The myopic eye can only produce sharply defined images of close objects from which the light rays diverge until they enter the eye (Fig. 16.8b). The far point moves closer; in myopia of –1 diopter it lies at a distance of 1 m. In myopia, the far point (distance from the eye = A) can be calculated using the formula: A (m) = 1/D, where D is myopia in diopters. Possible causes include an excessively long globe with normal refractive power (axial myopia; Fig. 16.8c) and, less frequently, excessive refractive power in a normal-length globe (refractive myopia; Fig. 16.8d). A difference in globe length of 1 mm with respect to a normal eye corresponds to a difference of about 3 diopters in refractive power. Special forms of refractive myopia. Myopic sclerosis of the nucleus of the lens (cataract) in advanced age (see p. 177). This causes a secondary focal point to develop, which can lead to monocular diplopia (double vision). Keratoconus (increase in the refractive power of the cornea). Spherophakia (spherically shaped lens). Forms. These include: Simple myopia (school-age myopia): Onset is at the age of 10–12 years. Usually the myopia does not progress after the age of 20. Refraction rarely exceeds 6 diopters. However, a benign progressive myopia also exists, which stabilizes only after the age of 30. Pathologic myopia. This disorder is largely hereditary and progresses continuously, independently of external influences. Tab. 16.2 Overview of the major refractive anomalies Refractive anomaly Focal point of parallel incident light rays Causes Vision Possible complications Optical correction Myopia (nearsightedness) Anterior to the retina Eyeball too long (axial myopia). Excessive refractive power (refractive myopia) Very good near vision. Poor distance vision Increased risk of retinal detachment. Diverging lenses (minus or concave lenses) Hyperopia (far-sightedness) Posterior to the retina Eyeball too short (axial hyperopia). Insufficient refractive power (refractive hyperopia) Poor near vision. Accommodation usually permits normal distance vision (in young patients and in slight to moderate hyperopia) Disposition to acute angle closure glaucoma (shallow anterior chamber). Caution is advised with diagnostic and therapeutic mydriasis. Esotropia Converging lenses (plus or convex lenses) Astigmatism Lack of a focal point Anomalies in the curvature of the normally spheri- cal surfaces of the refractive media (cornea and lens) Patients see everything dis- torted Risk of refractive amblyopia Cylindrical lenses; eyeglass correction is only possible where astigmatism is regular Lang, Ophthalmology: A Pocket Textbook Atlas, 2nd Ed. (ISBN 978-1-58890-555-0), copyright © 2007 Thieme Medical Publishers. All rights reserved. Usage subject to terms and conditions of license. Symptomsanddiagnosticconsiderations.The diagnosis is made on the basis of a typical clinical picture and refraction testing. Myopic patients have very good near vision. When gazing into the distance, they squint in an attempt to improve their uncorrected visual acuity by further narrowing the optic aperture of the pupil. The term “myopia” comes from this squinting; the Greek word “myein” means to squint or close the eyes. Older myopic patients can read without corrective lenses by holding the reading material at about the distance of the far point. The typical morphologic changes occurring in myopia are referred to as myopia syndrome. Progressive myopia in particular is characterized by thinning of the sclera. The elongation of the globe causes a shift in the axes of the eye. This often simulates esotropia. The anterior chamber is deep. Atrophy of the ciliary muscle is present as it is hardly used. The volume of the vitreous body is too small for the large eye, and it may collapse prematurely. This results in vitreous opacifications that the patient perceives as floaters. Morphologic fundus changes in myopia, such as maculopathy and Fuchs spot, are discussed in Chapter 12. The risk of retinal detachment is increased in myopia. However, it does not increase in proportion to the severity of the myopia. Because of the increased risk of retinal detachment, patients with myopia should be examined particularly thoroughly for prodromal signs of retinal detachment, such as equatorial degeneration or retinal tears. Therefore, examination of the fundus with the pupil dilated is indicated both when the first pair of eyeglasses is prescribed and at regular intervals thereafter. Glaucoma is more difficult to diagnose in patients with myopia. Measurements of intraocular pressure obtained with a Schiøtz tonometer will be lower than normal due to the decreased rigidity of the sclera. Applanation tonometry yields the most accurate values in patients with myopia because the rigidity of the sclera only slightly influences results. The optic cup is also difficult to evaluate in patients with myopia because the optic nerve enters the eye obliquely. This also makes glaucoma more difficult to diagnose. Treatment. The excessive refractive power of the refractive media must be reduced. This is achieved through the use of diverging lenses (minus or concave lenses; Fig. 16.9a). These lenses cause parallel incident light rays to diverge behind the lens. The divergent rays converge at a virtual focal point in front of the lens. The refractive power (D) is negative (hence the term “minus lens”) and is equal to 1/f, where f is the focal length in meters. Previously, biconcave or planoconcave lens blanks were used in the manufacture of corrective lenses. However, these entailed a number of optical disadvantages. Today lenses are manufactured in a positive meniscus shape to reduce lens aberrations. Correction with contact lenses (Fig. 16.9b) offers optical advantages. The reduction in the size of the image is less than with eyeglass correction. Aberrations are also reduced. These advantages are clinically relevant with myopia exceeding 3 diopters. The closer the “minus lens” is to the eye, the weaker its refractive power must be to achieve the desired optic effect. Minus lenses to be used to correct myopia should be no stronger than absolutely necessary. Although accommodation could compensate for an overcorrection, patients usually do not tolerate this well. Accommodative asthenopia (rapid ocular fatigue) results from the excessive stress caused by chronic contraction of the atrophic ciliary muscle. sharp image with minimal overcorrection. In certain special cases, removal of the crystalline lens (Fig. 16.9c) can be performed to reduce the refractive power of the myopic eye. However, this operation is associated with a high risk of retinal detachment and is rarely performed. There is also the possibility of implanting an anterior chamber intraocular lens (diverging lens) anterior to the natural lens to reduce refractive power. See Chapter 5 for additional surgical options. Popular health books describe exercises that can allegedly treat refractive errors such as nearsightedness without eyeglasses or contact lenses. Such exercises cannot influence the sharpness of the retinal image; they can only seemingly improve uncorrected visual acuity by training the patient to make better use of additional visual information. However, after puberty no late sequelae of chronically uncorrected vision are to be expected. Hyperopia (Farsightedness) Definition: In hyperopia, there is a discrepancy between the refractive power and axial length of the eye such that parallel incident light rays converge at a focal point posterior to the retina (Fig. 16.10a). Epidemiology. Approximately 20% of persons between the ages of 20 and 30 have refraction exceeding + 1 diopters. Most newborns exhibit slight hyperopia (newborn hyperopia). This decreases during the first few years of life. In advanced age, refraction tends to shift toward the myopic side due to sclerosing of the nucleus of the lens. Etiology. The mechanisms that coordinate the development of the eyeball so as to produce optic media of a given refractive power are not yet fully understood. Pathophysiology. In farsighted patients, the virtual far point of the eye lies posterior to the retina (Fig. 16.10b). Only convergent incident light rays can be focused on the retina (Fig. 16.10b). This is due either to an excessively short globe with normal refractive power (axial hyperopia; Fig. 16.10d) or, less frequently, to insufficient refractive power in a normal-length globe (refractive hyperopia; Fig. 16.10e). Axial hyperopia is usually congenital and is characterized by a shallow anterior chamber with a thick sclera and well developed ciliary muscle. Hyperopic eyes are predisposed to acute angle closure glaucoma because of their shallow anterior chamber. This can be provoked by diagnostic and therapeutic mydriasis. Special forms of refractive hyperopia. Absence of the lens (aphakia) due to dislocation Postoperative aphakia following cataract surgery without placement of an intraocular lens (see Fig. 16.10) To bring the focal point onto the retina, a farsighted person must accommodate even when gazing into the distance (Fig. 16.10c). Close objects remain blurred because the eye is unable to accommodate any further in near vision. As accommodation is linked to convergence, this process can result in esotropia (accommodative esotropia or accommodative convergent strabismus). Symptoms. In young patients, accommodation can compensate for slight to moderate hyperopia. However, this leads to chronic overuse of the ciliary muscle. Reading in particular can cause asthenopic symptoms such as eye pain or headache, burning sensation in the eyes, blepharoconjunctivitis, blurred vision, and rapid fatigue. Esotropia can also occur, as was mentioned above. As accommodation decreases with advancing age, near vision becomes increasingly difficult. For this reason, hyperopic persons tend to become presbyopic early. Diagnostic considerations. Ophthalmoscopic examination of the fundus may reveal a slightly blurred optic disc that may be elevated (hyperopic pseudoneuritis). However, this is not associated with any functional impairment such as visual field defects, loss of visual acuity, or color vision defects. The retina is too large for the small eye, which leads to tortuous retinal vascular structures. Transitions to abnormal forms of axial shortening, such as in microphthalmos, are not well defined. The ciliary muscle is chronically under tension in slight or moderate hyperopia to compensate for the hyperopia. This overuse of the ciliary muscle leads to a condition of residual accommodation in which the muscle is unable to relax even after the hyperopia has been corrected with plus lenses. This residual or latent hyperopia may be overlooked if refraction testing is performed without first completely paralyzing the ciliary body with cycloplegic agents such as cyclopentolate or atropine. The full extent of hyperopia includes both this residual hyperopia and clinically manifest hyperopia. In the presence of asthenopic symptoms of uncertain origin, refraction testing under cycloplegia is indicated to rule out latent hyperopia. Treatment. The insufficient refractive power must be augmented with converging lenses (plus or convex lenses; Fig. 16.11a). A watch-and-wait approach is indicated with asymptomatic young patients with slight hyperopia. Spherical plus lenses converge parallel incident light rays at a focal point behind the lens. The refractive power (D) in plus lenses is positive. It is equal to 1/f, where f is the focal length in meters. Previously, biconvex or planoconvex lens blanks were used in the manufacture of corrective lenses. However, these entailed a number of optical disadvantages. The optical aberrations of the positive meniscus lenses used today are comparatively slight. The clinician should determine the total degree of hyperopia present (see Diagnostic considerations) prior to prescribing corrective lenses. The second step is to prescribe the strongest plus lens that the patient can tolerate without compromising visual acuity. Care should be taken to avoid overcorrection. This will compensate for the manifest component of the hyperopia. If the patient wears these corrective lenses permanently, then with time it will also become possible to correct the latent component (see Diagnostic considerations). This is because the permanent tension in the ciliary body is no longer necessary. Prior to any correction of hyperopia, refraction testing should be performed after administering cycloplegics to the patient. The correction is then made with the strongest plus lens that the patient can subjectively tolerate without compromising visual acuity. In contrast, refraction testing to correct aphakia does not require cycloplegia. Here, too, plus lenses are required to correct the hyperopia. The closer the plus lens is to the retina, the stronger its refractive power must be to converge incident light at a point on the retina. For this reason, a cataract lens (Fig. 16.11b) has a refractive power of about 12 diopters, a contact lens (Fig. 16.11c) about 14 diopters, an anterior-chamber intraocular lens about 20 diopters (Fig. 16.11d), and a posterior-chamber lens about 23 diopters (Fig. 16.11e). See chapter 5 for additional surgical options. Astigmatism Definition: Astigmatism is derived from the Greek word stigma (point) and literally means lack of a focal point. The disorder is characterized by a curvature anomaly of the refractive media such that parallel incident light rays do not converge at a point but are drawn apart to form a line. Epidemiology. Forty-two percent of humans have astigmatism greater than or equal to 0.5 diopters. In approximately 20%, this astigmatism is greater than 1 diopter and requires optical correction. Pathophysiology. The refractive media of the astigmatic eye are not spherical, but refract differently along one meridian than along the meridian perpendicular to it (Fig. 16.12). Any amount of astigmatism at the axis orientation introduces a Sturm conoid into the image system. This produces two focal points. A punctiform object is therefore represented as a sharply defined line segment at the focal point of the first meridian, but also appears as a sharply defined line segment rotated 90 at the focal point of the second meridian. Midway between these two focal points is what is known as the “circle of least confusion.” This refers to the location at which the image is equally distorted in every direction—i.e., the location with the least loss of image definition. The aggregate system lacks a focal point. The combined astigmatic components of all of the refractive media comprise the total astigmatism of the eye. These media include: Anterior surface of the cornea. Posterior surface of the cornea. Anterior surface of the lens. Posterior surface of the lens. Rarely, nonspherical curvature of the retina may also contribute to astigmatism. Classification and causes. Astigmatism can be classified as follows: External astigmatism. Astigmatism of the anterior surface of the cornea. Internal astigmatism. The sum of the astigmatic components of the other media. The degree of astigmatism and its axis can change during life. Astigmatism can also be classified according to the location of the meridian of greater refraction: With-the-rule astigmatism (most common form). The meridian with the greater refractive power is vertical—i.e., between 70 and 110. Against-the-rule astigmatism. The meridian with the greater refractive power is horizontal—i.e., between 160 and 200. Oblique astigmatism. The meridian with the greater refractive power is oblique—i.e., between 20 and 70 or between 110 and 160. The discussion up to this point has proceeded from the assumption that the anomaly is a regular astigmatism involving only two meridians approximately perpendicular to each other (Fig. 16.12). This is presumably caused by excessive eyelid tension that leads to astigmatic changes in the surface of the cornea. The condition above should be distinguished from irregular astigmatism. Here, the curvature and the refractive power of the refractive media are completely irregular (Fig. 16.13a). There are multiple focal points, which produces a completely blurred image on the retina. This condition may be caused by the following diseases: Corneal ulcerations with resulting scarring of the cornea. Penetrating corneal trauma. Advanced keratoconus. Cataract. Lenticonus. Symptoms. Patients with astigmatism see everything distorted. Attempts to compensate for the refractive error by accommodation can lead to asthenopic symptoms such as a burning sensation in the eyes or headache. Diagnostic considerations. The keratoscope (Placido disc) permits gross estimation of astigmatism. The examiner evaluates the mirror images of the rings on the patient’s cornea. In regular astigmatism, the rings are oval; in irregular astigmatism, they are irregularly distorted. Computerized corneal topography (videokeratoscopy) can be used to obtain an image of the distribution of refractive values over the entire cornea (see Fig. 5.3). A Helmholtz or Javal ophthalmometer can be used to measure the central corneal curvature, which determines the refractive power of the cornea (Fig. 16.14). Treatment. Early correction is crucial. Untreated astigmatism in children will eventually lead to uncorrectable refractive amblyopia because a sharp image is not projected on the retina. Treatmentofregularastigmatism. The purpose of the correction is to bring the “focal lines” of two main meridians together at one focal point. This requires a lens that refracts in only one plane. Cylinder lenses are required for this application (Fig. 16.15a). Once the two “focal lines” have been converged into a focal point, additional spherical lenses can be used to shift this focal point onto the retina if necessary. Fig. 16.14 The diagram shows the corneal reflex images (outline cross, 1, and solid cross, 2) of the Zeiss ophthalmometer. These images are projected onto the cornea; the distance between them will vary depending on the curvature of the cornea. The examiner has to align the images by changing their angle of projection. After aligning them, the examiner reads the axis of the main meridian, the corneal curvature in millimeters, and the appropriate refractive power in diopters on a scale in the device. This measurement is performed in both main meridians. The difference yields the astigmatism. In irregular astigmatism, the images are distorted, and often a measurement cannot be obtained. Diagnosis of corneal astigmatism with an ophthalmometer Treatment of irregular astigmatism. This form cannot be corrected with eyeglasses. External astigmatism can be managed with a rigid contact lens (Fig. 16.13b), keratoplasty, or surgical correction of the refractive error. Irregular internal astigmatism is usually lens-related. In this case, removal of the lens with implantation of an intraocular lens is indicated. Only regular astigmatism can be corrected with eyeglasses. Anisometropia Definition: In anisometropia, there is a difference in refractive power between the two eyes. Epidemiology. Anisometropia of at least 4 diopters is present in less than 1% of the population. Etiology. The reason for the varying development of the two eyes is not clear. This primarily congenital disease is known to exhibit a familial pattern of increased incidence. Pathophysiology. In anisometropia, there is a difference in refractive power between the two eyes. This refractive difference can be corrected separately for each eye with different lenses as long as it lies below 4 diopters. Where the difference in refraction is greater than or equal to 4 diopters, the size difference of the two retinal images becomes too great for the brain to fuse the two images into one. Known as aniseikonia, this condition jeopardizes binocular vision because it can lead to development of amblyopia (anisometropic amblyopia). The aniseikonia, or differing size of the retinal images, depends not only on the degree of refractive anomaly but also depends significantly on the type of correction. The closer to the site of the refraction deficit the correction is made, the less the retinal image changes in size. Correction with intraocular lenses results in almost no difference in image size. Contact lenses produce a slight and usually irrelevant difference in image size. However, eyeglass correction resulting in a difference of more than 4 diopters leads to intolerable aniseikonia (see Table 7.4). Symptoms. Anisometropia is usually congenital and often asymptomatic. Children are not aware that their vision is abnormal. However, there is a tendency toward strabismus as binocular functions may remain underdeveloped. Where the correction of the anisometropia results in unacceptable aniseikonia, patients will report unpleasant visual sensations of double vision. Diagnostic considerations. Anisometropia is usually diagnosed during routine examinations. The diagnosis is made on the basis of refraction testing. 16.4 Impaired Accommodation Treatment. The refractive error should be corrected. Anisometropia exceeding 4 diopters cannot be corrected with eyeglasses because of the clinically relevant aniseikonia. Contact lenses and, in rare cases, surgical treatment are indicated. Patients with unilateral aphakia or who do not tolerate contact lenses will require implantation of an intraocular lens. Correction of unilateral aphakia with unilateral glasses is usually contraindicated because it results in aniseikonia of approximately 25%. 16.4 Impaired Accommodation Accommodation Spasm Definition: An accommodation spasm is defined as inadequate protracted contraction of the ciliary muscle. Etiology. Accommodation spasms are rare. They may occur as functional impairment or they may occur iatrogenically when treating young patients with parasympathomimetic agents (miotic agents). The functional impairments are frequently attributable to heightened sensitivity of the accommodation center, which especially in children (often girls) can be psychogenic. Rarely the spasm is due to organic causes. In these cases, it is most often attributable to irritation in the region of the oculomotor nuclei (from cerebral pressure or cerebral disorders) or to change in the ciliary muscle such as in an ocular contusion. Symptoms. Patients complain of deep eye pain and blurred distance vision (lenticular myopia). Diagnostic considerations and differential diagnosis. The diagnosis is made on the basis of presenting symptoms and refraction testing, including measurement of the range of accommodation. This is done with an accommodometer, which determines the difference in refractive power between the near point and far point. A differential diagnosis should exclude latent hyperopia. In children, this will frequently be associated with accommodative esotropia and accommodative pupil narrowing. Treatment. This depends on the underlying disorder. Cycloplegic therapy with agents such as tropicamide or cyclopentolate may be attempted in the presence of recurrent accommodation spasms. Prognosis. Iatrogenic spasms are completely reversible by discontinuing the parasympathomimetic agents. The prognosis is also good for patients with functional causes. Spasms due to organic causes require treatment of the underlying disorder but once treatment is initiated the prognosis is usually good. Accommodation Palsy Definition: Failure of accommodation due to palsy of the ciliary muscle. Etiology. This rare disorder is primarily due to one of the following causes: Iatrogenic drug-induced palsy due to parasympatholytic agents such as atropine, cyclopentolate scopolamine, homatropine, and tropicamide. Peripheral causes. Oculomotor palsy, lesions of the ciliary ganglion, or the ciliary muscle. Systemic causes. Damage to the accommodation center in diphtheria, diabetes mellitus, chronic alcoholism, meningitis, cerebral stroke, multiple sclerosis, syphilis, lead or ergotamine poisoning, medications such as isoniazid or piperazine, and tumors. Symptoms. The failure of accommodation leads to blurred near vision and may be associated with mydriasis where the sphincter pupillae muscle is also involved. The clinical syndromes listed below exhibit a specific constellation of clinical symptoms and therefore warrant further discussion. Post-diphtheriaaccommodationpalsy. This transitory palsy is a toxic reaction and occurs without pupillary dysfunction approximately 4 weeks after infection. Sometimes it is associated with palsy of the soft palate and/ or impaired motor function in the lower extremities. Accommodation palsy in botulism. This is also a toxic palsy. It does involve the pupil, producing mydriasis, and can be the first symptom of botulism. It is associated with speech, swallowing, and ocular muscle dysfunction accompanied by double vision. Tonic pupillary contraction is associated with tonic accommodation. Sympathetic ophthalmia is characterized by a decrease in the range of accommodation, even in the unaffected eye. Measurement of the range of accommodation is indicated whenever sympathetic ophthalmia is suspected. Diagnostic considerations. In addition to measuring the range of accommodation with an accommodometer, the examiner should inquire about other ocular and general symptoms. Treatment. This depends on the underlying disorder. Prognosis. The clinical course of tonic pupillary contraction is chronic and results in irreversible loss of accommodation. The toxic accommodation palsies are reversible once the underlying disorder is controlled. 16.5 Correction of Refractive Errors Eyeglass Lenses Monofocal Lenses There are two basic types. Spherical lenses refract light equally along every axis Toric lenses (known as cylindrical lenses) refract light only along one axis Spherical and toric lenses can be combined where indicated. The refractive power of the lenses is measured manually or automatically with an optical interferometer. The measured refraction is specified as spherocylindrical combination. By convention, the specified axis of the cylindrical lens is perpendicular to its axis of refraction (Fig. 16.15c, d). The orientation of this axis with respect to the eye is specified on a standardized form (Fig. 16.16). Example. + 4.00 diopters – 2.00 diopters/90 means that the lens represents a combination of converging lens (+ 4 diopters) and cylindrical lens (– 2 diopters) with its axis at 90. Eyeglass lenses exhibit typical characteristics when moved back and forth a few inches in front of one’s eye. Objects viewed through minus lenses appear to move in the same direction as the lens; objects viewed through plus lenses move in the opposite direction. A cylindrical lens produces image distortions when turned. Multifocal Lenses Multifocal lenses differ from the monofocal lenses of uniform refractive power discussed in the previous section in that different areas of the lens have different refractive powers. These lenses are best understood as combinations of two or more lenses in a single lens. Bifocals. The upper and middle portion of the lens is ground for the distance correction; the lower portion is ground for the near-field correction (Fig. 16.17). Patients are able to view distant objects in focus and read using one pair of eyeglasses, eliminating the need to constantly change glasses. The gaze is lowered and converged to read. This portion of the lens contains the nearfield correction. This near-field correction can be placed in a different part of the lens for special applications. Trifocals. These lenses include a third refractive correction between the distance and near-field portions. This intermediate portion sharply images the intermediate field between distance vision and reading range without any need for accommodation (Fig. 16.17). Progressive addition lenses. These lenses were developed to minimize abrupt image changes when the gaze moves through the different correction zones of the lens while maintaining a sharp focus at every distance (Fig. 16.17). These eyeglasses also offer cosmetic advantages. They produce well focused images in the central region but have a high degree of peripheral astigmatism. However, many patients learn to tolerate this peripheral distortion. Presbyopic patients tolerate progressive addition lenses better when they still have only slight presbyopia and have not previously worn bifocals. Special Lenses The following types of lens have been developed for special applications: Plastic lenses. These lenses reduce the weight of eyeglasses where severe ametropia must be corrected. Another advantage is that these lenses are largely shatterproof, which is why they are preferred for children. However, they are easily scratched. Absorption lenses. These lenses are indicated in patients with increased sensitivity to glare. Operating motor vehicles in twilight or at night with eyeglasses that absorb more than 20% of incident light is dangerous because of the resulting reduction in visual acuity. Photochromatic lenses. These lenses darken in response to the intensity of ultraviolet light. The lenses become darker at low temperatures than at high temperatures; they lighten more slowly at low temperatures and more rapidly at high temperatures. Light attenuation ranges between 15 and 50% in some lenses and between 30 and 65% in others. Photochromatic lenses pose problems for patients operating motor vehicles. The lenses darken only slightly in a warm car with the windows closed, due to the lack of ultraviolet light. Dark lenses lighten too slowly when the car enters a tunnel. Coated lenses. Extremely thin coatings of magnesium fluoride can be applied to lenses to reduce surface reflection on the front and back of the lens. Subjective Refraction Testing for Eyeglasses While the patient looks at vision charts, the examiner places various combinations of lenses in front of the patient’s eye. The patient reports which of two lenses produces the sharper image. The better of the two is then compared with the next lens. This incremental method identifies the optimal correction. It is expedient to use the patient’s objective refraction as the starting point for subjective testing. Refraction testing is performed either with a series of test lenses from a case or with a Phoroptor, which contains many lenses that can be automatically or manually placed before the patient’s eye. The examination proceeds in three stages: Monocular testing. The optimal refraction for achieving best visual acuity is determined separately for each eye. The weakest possible minus lens is used in myopic patients, and the strongest possible plus lens in hyperopic patients. The red–green chromatic aberration test can be used for fine refraction. In this test, the patient compares optotypes on green and red backgrounds. Fine adjustment of refraction permits precise shifting of the focal point of the light on the retina. Optotypes on both red and green backgrounds then appear equally sharply defined. Binocular testing. The objective of this stage is to achieve a balance between both eyes. Near point testing. The final stage of the examination determines the patient’s near visual acuity, and, if necessary, the presbyopic addition. Allowance is made for the patient’s preferred reading and working position. The values determined by this examination are entered in the eyeglass prescription (see Fig. 16.16). The vertex distance at which refraction was performed is an important additional parameter for the optician. This is the distance between the back surface of the test lens and the anterior surface of the cornea. If the manufactured eyeglasses have a different vertex distance, then the strength of the lenses should be altered accordingly. This is because the optical effect of eyeglass lenses varies according to the distance from the eye. Before the lenses are fitted into the frame, the distance between the pupils must be measured to ensure that the lenses are properly centered. The center of the lens should be in front of the pupil. The prismatic effects of eccentric lenses might otherwise cause asthenopic symptoms such as headache or a burning sensation in the eyes. To facilitate early detection of glaucoma, intraocular pressure should be measured in any patient over the age of 40 presenting for refraction testing for eyeglasses. Contact Lenses Advantages and Characteristics of Contact Lenses Contact lenses are in immediate contact with the cornea. Although they are foreign bodies, most patients adapt to properly fitted contact lenses. Contact lenses differ from eyeglasses in that they correct the refractive error closer to the location of its origin. For this reason, the quality of the optical image viewed through contact lenses is higher than that viewed through eyeglasses. Contact lenses have significantly less influence on the size of the retinal image than does correction with eyeglasses. Lenses do not cloud up in rainy weather or steam, and peripheral distortion is minimized. The cosmetic disadvantage of thick eyeglasses in severe ametropia is also eliminated. Severe anisometropia requires correction with contact lenses for optical reasons— i.e., to minimize aniseikonia. Contact lenses are defined by the following characteristics: Diameter of the contact lens Radius of curvature of the posterior surface Geometry of the posterior surface—i.e., spherical, aspherical, complex curvature, or toric Refractive power Material Oxygen permeability of the material (Dk value) The cornea requires oxygen from the precorneal tear film. To ensure this supply, contact lens materials must be oxygen-permeable. This becomes all the more important the less the contact lens moves and permits circulation of tear fluid. Contact lenses can be made of rigid or flexible materials. Rigid Contact Lenses These contact lenses have a stable, nearly unchanging shape. Patients take some time to become used to them and should therefore wear them often. The goal is to achieve the best possible intimacy of fit between the posterior surface of the lens and the anterior surface of the cornea (Fig. 16.18). This allows the contact lens to float on the precorneal tear film. Every time the patient blinks, the lens is displaced superiorly and then returns to its central position. This permits circulation of the tear film. Previously, polymethylmethacrylate (PMMA) was used as a material. However, this is practically impermeable to oxygen. The lenses were fitted in small diameters with a very shallow curvature; the central area maintained contact with the cornea while the periphery projected. This allowed excellent tear film circulation, and patients were able to wear the lenses for surprisingly long periods. Today, highly oxygen-permeable materials such as silicone copolymers are available. This eliminates the time limit for daily wearing. These lenses may also remain in the eye overnight in special cases, such as aphakic patients with poor coordination (prolonged wearing). Rigid contact lenses can be manufactured as spherical lenses and toric lenses. Spherical contact lenses can almost completely compensate for corneal astigmatism of less than 2.5 diopters. This is possible because the space between the posterior surface of the spherical contact lens and the anterior surface of the astigmatic cornea is filled with tear fluid that forms a “tear lens.” Tear fluid has nearly the same refractive index as the cornea. More severe corneal astigmatism or internal astigmatism requires correction with toric contact lenses. Rigid contact lenses can even correct severe keratoconus. Soft Contact Lenses The material of the contact lens, such as hydrogel, is soft and pliable. Patients find these lenses significantly more comfortable. The oxygen permeability of the material depends on its water content, which may range from 36 to 85%. The higher the water content, the better the oxygen permeability. However, it is typically lower than that of rigid lenses. The material is more permeable to foreign substances, which can accumulate in it. At 12.5–16 mm, flexible lenses are larger in diameter than rigid lenses. Flexible lenses are often supported by the limbus. The lens is often displaced only a few tenths of a millimeter when the patient blinks. This greatly reduces the circulation of tear film under the lenses. This limits the maximum daily period that patients are able to wear them and requires that they be removed at night to allow regeneration of the cornea. Deviation from this principle is only possible in exceptional cases under the strict supervision of a physician. As the lenses are almost completely in contact with the surface of the cornea, corneal astigmatism cannot be corrected with spherical soft lenses. This requires toric soft lenses. Special Lenses The following types of special lens are available for specific situations: Therapeutic contact lenses. In the presence of corneal erosion, soft ultra-thin (0.05 mm) contact lenses act as a bandage and thereby accelerate reepithelialization of the cornea. They also reduce pain. Soft contact lenses may also be used in patients receiving topical medication as they store medication and only release it very slowly. Corneal shields. These are collagen devices that resemble contact lenses. These shields are gradually broken down by the collagenase in the tear film. They are used as bandages and substrates for topical medication in the treatment of anterior disorders, such as erosion or ulcer. Iris print lenses. These colored contact lenses with a clear central pupil are used in patients with aniridia and albinism. They produce good cosmetic results, reduce glare, and can correct a refractive error where indicated. Bifocalcontactlenses. These lenses were developed to allow the use of contact lenses in presbyopic patients. As in eyeglasses, a near-field correction is ground into the lens. This near-field portion is always located at the bottom of the lens because the lens is heavier there. When the patient gazes downward to read, the immobile lower eyelid pushes this near-field portion superiorly where it aligns with the pupil and becomes optically effective. Another possibility is diffraction (bending of light rays as opposed to refraction) through concentric rings on the posterior surface of the contact lens. This produces two images, a distant refractive image and a near-field diffractive image. The patient chooses the image that is important at the moment. It is also possible to correct one eye for distance vision and the fellow eye for near vision (monocular vision). Disadvantages of Contact Lenses Contact lenses exert mechanical and metabolic influences on the cornea. Therefore, they require the constant supervision of an ophthalmologist. Mechanical influences on the cornea can lead to transient changes in refraction. “Spectacle blur” can result when eyeglasses suddenly no longer provide the proper correction after removing the lens. Contact lenses require careful daily cleaning and disinfection. This is more difficult, time-consuming, and more expensive than eyeglass care and is particular important with soft lenses. Metabolic influences on the cornea. The macromolecular mesh of material absorbs proteins, protein breakdown products, low-molecular-weight substances such as medications and disinfectants, and bacteria and fungi. Serious complications can occur where daily care of the contact lenses is inadequate. With their threshold oxygen permeability, soft contact lenses interfere with corneal metabolism. Contact lenses are less suitable for patients with symptoms of keratoconjunctivitis sicca. Contact Lens Complications Complications have been observed primarily in patients wearing soft contact lenses. These include the following: Infectious keratitis (corneal infiltrations and ulcers) caused by bacteria, fungi, and protozoans. Acanthamoeba keratitis is a serious complication affecting wearers of soft contact lenses and often requires penetrating keratoplasty. Giant papillary conjunctivitis. This is an allergic reaction of the palpebral conjunctiva of the upper eyelid to denatured proteins. It results in proliferative “cobblestone” conjunctival lesions. Corneal vascularization can be regarded as resulting from an inadequate supply of oxygen to the cornea. Severe chronic conjunctivitis. This usually makes it impossible to continue wearing contact lenses. Prisms Prisms can change the direction of parallel light rays. The optical strength of a prism is specified in prism diopters. Prism lenses can be combined with spherical and toric lenses. When prescribing eyeglasses, the ophthalmologist specifies the strength and the position of the base of the prism. Prism lenses are used to correct heterophoria (latent strabismus) and ocular muscle palsies, and in preparation for surgery to correct strabismus. A 1 diopter prism deflects a ray of light 1 cm at a distance of 1 m from the base of the prism. Magnifying Vision Aids The reduction in central corrected visual acuity as a result of destruction of the fovea with a central scotoma requires magnifying vision aids. However, magnification is always associated with a reduction in the size of the visual field. As a result, these vision aids require patience, adaptation, motivation, and dexterity. Cooperation between ophthalmologist and optician is often helpful. The following systems are available in order of magnification: Increased near-field corrections. The stronger the near-field correction, the shorter the reading distance. Magnification (V) is a function of the refractive power of the near-field correction (D) and is determined by the equation V = D/4. Example. Eyeglasses with a 10 diopter near-field correction magnify the image two and one-half powers. However, the object must be brought to within 10 cm of the eye. 16.6 Aberrations of Lenses and Eyeglasses Magnifying glasses are available in various strengths, with or without illumination. Monocular and binocular loupes, telescopes, and prism loupes. An optical magnifying system is mounted on one or both eyeglass lenses. The optical system functions on the principle of Galilean or Keplerian optics. Closed-circuitTVmagnifier. This device displays text at up to 45 power magnification. 16.6 Aberrations of Lenses and Eyeglasses Optical lens systems (eyeglasses or lenses) always have minor aberrations. These aberrations are not material flaws, rather they are due to the laws of physics. Expensive optical systems can reduce these aberrations by using many different lenses in a specific order. Chromatic Aberration (Dispersion) This means that the refractive power of the lens varies according to the wavelength of the light. Light consists of a blend of various wavelengths. Light with a short wavelength such as blue is refracted more than light with a long wavelength such as red (Fig. 16.19). This is why monochromatic light (light of a single wavelength) produces a sharper image on the retina. Chromatic aberration is the basis of the red–green test used for fine refraction testing. Spherical Aberration This means that the refractive power of the lens varies according to the location at which the light ray strikes the lens. Patients may report being able to see better when looking through a disc with a pinhole (a stenopeic aperture) than without it. This usually is a sign of an uncompensated refractive error in the eye. The further peripherally the light ray strikes the lens, the more it will be refracted (Fig. 16.20). The iris intercepts a large share of these peripheral light rays. A narrow pupil will intercept a particularly large share of peripheral light rays, which improves the depth of field. Conversely, depth of field is significantly poorer when the pupil is dilated. Patients who have received mydriatic agents should refrain from driving. Astigmatic Aberration A punctiform object viewed through a spherical lens appears as a line. If one looks through a lens obliquely to its optical axis, it will act as a prism (Fig. 16.21). A prism refracts a light ray toward its base (Fig. 16.21b). In addition to this, the light is split into its component spectral colors. Light with a short wavelength (blue) is refracted more than light with a long wavelength (red). Astigmatic aberration is an undesired side effect that is present whenever one looks through a lens at an oblique angle. This phenomenon should be distinguished from astigmatic or toric lenses, which correct for astigmatism of the eye when the patient looks through them along the optical axis. Curvature of Field This means that the magnification of the image changes as one approaches the periphery. The result is a sharp image with peripheral curvature. Convex or plus lenses produce pincushion distortion; concave or minus lenses produce barrel distortion (Fig. 16.22). 16.5 Correction of Refractive Errors