VLFA08222p - Pharmacology II lecture General medicine Spring semester 2019 19. 2. 2019 1. INTRODUCTION TO PSYCHOPHARMACOLOGY, ANTIPSYCHOTICS, ANTIPARKINSONICS Lecture content: History and classification of psychotropic substances. Antipsychotics, antiparkinsonics – basic pharmacological review. 26. 2. 2019 2. ANXIOLYTICS, HYPNOSEDATIVES, ANTICONVULSANTS Lecture content: Anxiolytics, hypnosedatives, anticonvulsants - basic pharmacological review. The possibilities of modulation of GABAergic neurotransmission. 5. 3. 2019 3. ANTIDEPRESSANTS Lecture content: Pharmacological review of antidepressants and their clinical use. 12. 3. 2019 4. DRUGS OF DISEASES WITH CHRONIC PULMONARY OBSTRUCTION, H[ 1]-ANTIHISTAMINES. Lecture content: Effects of histamine and how to antagonize it. Classification of H[ 1] antihistamines. Pharmacological review of drugs used in the therapy of diseases with chronic pulmonary obstruction. 19. 3. 2019 5. ANTIANGIAL DRUGS Lecture content: Pharmacological review of drugs used in the treatment of both acute and chronic ischemic heart disease. 26. 3. 2019 6. ANTIHYPERTENSIVES Lecture content: Pharmacological review of antihypertensives with special focus on drugs interfering with RAAS and diuretics. Second-line antihypertensives. 2. 4. 2019 7. DRUGS OF HEART FAILURE, ANTIARRHYTHMICS Lecture content: Review of drugs used in the therapy of acute and chronic heart failure, Pharmacological review of antiarrhytmics. 9. 4. 2019 8. DRUGS INFLUENCING HEMOSTASIS Lecture content: Pharmacological review of anticoagulants, antiplatelets, fibrinolytics, and hemostatics. 16. 4. 2019 9. ANTI-INFECTIVES I - ANTIBIOTICS Lecture content: Introduction/principles of ATB therapy, modes of resistance, pharmacological review of single groups of ATBs. 23. 4. 2019 10. ANTI-INFECTIVES II – ANTIMYCOTICS AND ANTIVIRALS Lecture content: Systemic and local antimycotics; antiherpetics; pharmacotherapy of influenza; antiretrovirals; therapy of RSV and viral hepatitis – pharmacological review. 30. 4. 2019 11. PHARMACOLOGY OF GIT – ULCER DISEASE, ANTIEMETICS, ANTIDIARRHEALS AND LAXATIVES Lecture content: Pharmacological review of drugs acting on GIT. 7. 5. 2019 12. CYTOSTATICS AND TARGETED THERAPY IN ONCOLOGY Lecture content: Introduction. Classification of cytostatics according to their mechanisms of action. Mechanisms of resistance to anticancer drugs. Role of single nucleotide polymorphisms (SNPs) and TDM in oncology. Basic pharmacological properties of selected cytostatics. Principles of targeted therapy in oncology. Monoclonal antibodies. Protein kinase inhibitors. Targeted immunotherapy. 14. 5. 2019 13. THERAPY OF INTOXICATIONS Lecture content: Review of most common intoxications and their symptomatology.. General principles of poisoning management. Specific antidotes in poisoning therapy. 21. 5. 2019 14. DRUG-DRUG INTERACTIONS Lecture content: Classification of drug-drug interaction, evaluation of clinical relevance and seriousness oc drug interactions, management of drug interactions, possibilities of drug interactions monitoring, case-reports. 28. 5. 2019 15. PHYTOPHARMACOLOGY AND PHARMACOGNOSY Lecture content: Natural sources of medicines, selected groups of herbal active components, herbal preparations. The most common herbal poisons.