Parasitic gastrointestinal infections Prof. MUDr. Petr Husa, CSc. Klinika infekčních chorob LF MU a FN Brno Parasitic infection of GI tract •protozoal •helmintic •fungal Protozoal infections •Human •Amebiasis (Entamoeba histolytica) •Lambliasis = girardiasis (L., G. intestinalis) •Zoonotic •cryptosporidiosis (Cryptosporidium parvum) •isosporosis (Isospora belli) •microsporidiosis (Enterocytozoon bineusi) •cyclosporosis (Cyclospora cayetanensis) • Amebiasis_LifeCycle Amebiasis Entamoeba histolytica améba - střevo Amebic colitis absces pred drenazi CT – day 0 Amebic abscess absces drenaz CT – drainage of 2 abscesses – day 2 Amebic abscess absces uvodni UZ US – day 0 absces posledni UZ US – day 5 břicho 1 pytlík zkumavka 3 amépa punkce abscesu Amebic abscess – transcutaneus punction Giardia_LifeCycle Lambliasis, girardiasis Lamblia, Giardia intestinalis lamblie mikro Lambliasis microscopy lamblie scan Lambliasis scan Helmintic GI infections •Roundworms (Nematodes) - ascariosis, enterobiosis=oxyuriosis, trichuriosis •Tapeworms (Cestodes) - teniosis, diphylobotriosis, hymenolepsiosis, echinococcosis, alveococcosis •Flukes (Trematodes) - schistosomosis Roundworms (Nematodes) •Ascaris lumbricoides •Enterobius, Oxyuris vermicularis •Trichuris trichiura • Ascariasis_LifeCycle Ascariosis Ascaris lumbricoides škrkavka Differential diagnosis: earthworm - reproductive band (hermaphrodite) - round terminations Ascaris lubricoides škrkavky ze zadku škrkavka žlučovod škrvka ileus Trichuris_LifeCycle Trichuriosis Trichuris trichiura trichuris trichuris prolaps rekta Enterobius_LifeCycle Enterobiosis, oxyuriosis Enterobius, Oxyuris vermicularis roupy vyšetření Enterobiosis, oxyuriosis Tapeworms (Cestodes) •Man as final host •Taenia saginata •Taenia solium •Diphyllobotrium latum, D. pacificum •Hymenolepsis nana • •Animal as final host •Echinococcus granulosus •Echinococcus (Alveococcus) multilocularis • • • Taenia_LifeCycle Taeniosis Taenia saginata Taenia solium Cysticercosis_LifeCycle Cysticercosis Taenia solium hlavičky tasemnic Taenia solium Taenia saginata taenia saginata červ Taenia solium taenia saginata červ2 Taenia saginata cysticerkóza u prasete Cysticercosis (pig) cysticerkóza člověk Cysticercosis (man) cysticerkóza kráva Cysticercosis (cow) Echinococcus_LifeCycle Echinococcosis Alveococcosis E. granulosus, E.multilocularis echinokok červ Echinococcus granulosus (dog) echinokok CT Echinococcus granulosus – liver cysts (man) echinokok cysta Echinococcus granulosus – liver cysts (man) Flukes (Trematodes) •schistosomiasis (bilharsiasis) •S. hematobium •S. intestinalis (mansoni) •S. japonicum •S. mekongi • Schistomes_LifeCycle Schistosomosis, bilharziosis schistosoma šneci Katayama fever schistosoma ascites schistosoma kalcifikace Fungal GI infections •about all candidiasis •different members of Candida sp. (mostly C.albicans) •mounth cavity, oesophagus, anorectal •mostly IS patients •fluconazol, itraconazol, ketoconazol, amphotericin B husa-tenisky Thank you for your attention! Husa.petr@fnbrno.cz