Adobe Systems Department of Pharmacology 1 Notes for Students This study material is exclusively for students of general medicine and stomatology in Pharmacology I course. It contains only basic notes of discussed topics, which should be completed with more details and actual information during practical courses to make a complete material for test or exam studies. Which means that without your own notes from the lesson this presentation IS NOT SUFFICIENT for proper preparation for neither tests in practicals nor the final exam. RULES OF DRUG PRESCRIPTION Adobe Systems o Individually prepared preparations (IPP): oprepared in the pharmacies on the base of individual medical prescriptions o o Ready-made drug preparations (RMP): o final preparations made by pharm. companies, o ready to be issued by the pharmacy to patients without any further modifications o Adobe Systems ̶Covered by insuarance company (fully) ̶Covered by patient + ins. comp. (in part) ̶Covered by patient (fully) Expedition is §bound upon prescription §unbound upon Rx (OTC) Both in pharmacies and in other places (supermarkets, petrol stations, etc.) only in pharmacies „earmarked drugs“ (since 1998): act 378/ 2007, 106/2008 Sb., „about good practice of the sellers of earmarked drugs and about the specialized education of sellers of earmarked drugs“ Drug preparations Adobe Systems RULES FOR DRUG PRESCRIPTION § refers to the valid Pharmaceuticals Act 378/ 2007 § and from the related acts and regulations 54/2008 and 106/2008. Adobe Systems PRESCRIPTION § official document compiled in accordance with fixed rules. § written in Latin language § must have all parts filled up, must be legible § corrections should be signed by the physician § following the abbreviation corr. (correxit-corrected) §written in a non-erasible manner § max. 2 kinds of medicines/one form of Rx Adobe Systems recept Adobe Systems recept Inscriptio Personalia aegroti Invocatio Ordinatio Compositio (Praescriptio) Subscriptio Signatura Stamp, name of the doctor date signature Adobe Systems §Inscriptio §the heading of the prescription §Personalia aegroti §patient s personal data (name, surname, birth number and domicile) § Invocatio §induced by the abbreviation Rp. (recipe take). § Ordinatio § the actual prescription of the healing preparation = compositio + subscriptio + signatura Adobe Systems §RMP §the trade name in the nominative, §specification of pharmaceutical dosage form, §dose and package § § IPP § list of pharmacopoeial (officinal) names of substances in the genitive of singular §+ dosages and package COMPOSITIO Adobe Systems SUBSCRIPTIO ̶Instruction for the pharmacist §RMP – how many packages should be issued ̶4th case sg. or pl. ̶Expeditionem originalem numero unam – Exp.orig.No.I ̶Expeditiones originales numero duas – Exp.orig.No.II (duas) §IPP – how the preparation should be made of the prescribed components Misce fiat (sg) Misce fiant (pl) – mix to obtain … Different dosage forms: ̶ - misce fiat pulvis - M.f.pulv. , unguentum - M.f.ung. solutio - M.f.sol., oculoguttae - M.f.oculogutt ̶ Adobe Systems SIGNATURA D.S. Detur (et) Signetur Exact use instruction for patient – dose, interval, where to apply instructions how the preparation should be used by the patients. D.S. 3 times a day 1 tbl. Adobe Systems § date § the stamp of the health facility § the identification of the physician § and the physician s personal signature Adobe Systems recept Acidi borici 2,0 Vaselini albi ad 100,0 M. f. ung. D.S. twice a day on the focus Adobe Systems recept Paralen 125 tbl. 20 x 125 MG Exp. orig. No. III (tres) D.S. 1 tablet in pain, maximum 4 per day Adobe Systems Validity of prescription • Common Rx – 14 days • ATB – 5 days • ATB topically – 14 days • Narcotics, Psychotropics – 14 days • Rx for repeated issue – 6 moths, max 1 Year • Rx issued by emergency next day after the Rx issue (= max. 48 h) • Date – Rx not valid if missing • Validity may be prologned by physician Adobe Systems Symbols in Rx formulary ! – when max. dose was exceeded ® - physician specify „not to be substituted with generic medicine“ „PERICULUM IN MORA“ – emergency situation,when normal form is not available Adobe Systems Slovakia Adobe Systems RP GB UK Adobe Systems RP SRN Germany Adobe Systems rx2california[1] USA Adobe Systems File0263 Greece Adobe Systems Electronic Prescription § Physician § Central server for data storage (SÚKL) § Pharmacy § Patient + his password/PIN Adobe Systems Common and E-prescription Adobe Systems Narcotics and psychotropic drugs blue band on the form very strict accounting three copies only one preparation 14 days of validity ̶ Adobe Systems Adobe Systems Drug information databases EMA http://www.ema.europa.eu/ema/ Dynamed http://web.ebscohost.com/dynamed/search/basic?sid=d3f0d39b-dd7c-4bab-9f4f-3478d4639a2e%40sessionmgr 4008&vid=0&hid=4107 Medicines.org.uk Drugs.com https://www.drugs.com/ Micromedex http://www.thomsonhc.com/hcs/librarian Adobe Systems Drug information databases National databases SÚKL www.sukl.cz AISLP www.aislp.cz Pharmindex Remedia Pharmindex Brevíř