Nerve tissue Nerve tissue Neurons Glial cells Classification by: • size • number of processes • axon length • mediators • position in neuronal network • function Central (CNS) • oligodendrocytes • astrocytes • ependymal cells • microglia Peripheral (PNS) • satellite cells • Schwann cells Neuron Cortex cerebri – overview Cortex cerebri – Pyramidal cells – multipolar neurons Cortex cerebri – Pyramidal cells – multipolar neurons Cerebellum – overview Cerebellum – Purkinje cell Cerebellum – Nissl substance Medulla spinalis Somatomotoric multipolar neurons Medulla spinalis - somatomotoric multipolar neuron Medulla spinalis Somatomotoric multipolar neurons Myelinated axons Medulla spinalis Ependymal cells of canalis centralis Pseudounipolar neurons Satellite cells Ganglion spinale Vegetative ganglion – ganglionic cells (multipolar neurons), satellite cells Vegetative ganglion – ganglionic cells (multipolar neurons), satellite cells Ganglionic cells with lipofuscin Peripheral nerve Cross section Longitudinal sections Peripheral nerve - connective tissue Endoneurium Perineurium Epineurium Peripheral nerve - node of Ranvier Node of Ranvier Peripheral nerve Myelin sheath with nodes of Ranvier (OsO4) Motor end plates in motor unit telodendria Motor end plate Skeletal muscle fibers Motor end plates in motor unit (detection of acetylcholinesterase) Axons with Schwann sheath Nucleus of Schwann cell Myelin sheath Myelin and Schwann sheath Presynaptic ending Synapsis Synapsis 1. presynatic ending 2. synaptic cleft 3. postsynaptic membrane 4. perikaryon 5. synaptic vesicles 6. mitochondria 7. microtubules Neurotransmitters 1. adrenaline 2. noradrenaline 3. dopamine 4. serotonin 5. GABA 6. acetylcholine 7. glutamate 8. endorphins Hematoencephalic (bloood-brain) barrier 1. endothelial cell 2. pericyte 3. lamina basalis 4. perivascular feet of the astrocyte 5. erythrocyte 6. microglia 7. phagosomes in microglia Nerve tissue Slides: Pyramidal cell (75, 76. Cortex cerebri) Purkinje cell (77. Cerebellum) Nissl substance (78. Cerebellum) Somatomotoric multipolar neuron (79. Medulla spinalis) Pseudounipolar neuron (81. Ganglion spinale) Myelin sheath (87. Peripheral nerve) Motor-end plate (Acetylcholinesterase) Electronograms: Atlas of Cytology and Embryology https://www2.med.muni.cz/histology/multimedia-and-textbooks/ Numbers by the slides indicate their positions in sets in Microscopic Hall, not in online atlases. These numbers allow you to find the slides easily and study them using a microscope when the normal classes are opened.