1 Department of Anatomy AUTONOMIC NERVOUS SYSTEM MUDr. Marek Joukal, Ph.D. AUTONOMIC NERVOUS SYSTEM FUNCTION: fylogenetically the oldest part of NS, control smooth muscles, glands, heart FUNCTIONAL DIVISIONS: Parasympaticus – anabolic reactions (store the energy) Sympaticus – catabolic function (release the energy) Enteric system ■ coronary arteries - vasodilation ■ ↑ heart rate, blood pressure ■ bronchodilation ■ mydriasis ■ sweat secretion ■ ↑ glykemia Generalised reaction of the body Sympaticus = fight or flight Catabolic reaction • ↓ heart rate, blood pressure • bronchoconstriction • GIT activation • miosis Localized reaction Parasympaticus = Anabolic reaction Parasympaticus Sympaticus Ach Ach Ach Adrenalin Ach – sweat glands CENTRAL PART OF AUTONOMIC NERVOUS SYSTEM Hypothalamus (subsystem of limbic brain = visceral brain) Ncll. hypothalamici ant. control parasympaticus (fasciculus longitudinalis dorsalis) Ncll. hypothalamici medii Control the sympaticus (over RF, tr. tegmentalis centralis) 2 PARASYMPATICUS (cranio-sacral system) Ncl. parasympaticus n. III. (ggl. ciliare) Ncl. parasympaticus n. VII. (ggl. pterygopalatinum, ggl.submandibulare) Ncl. parasympaticus n. IX. (ggl. oticum) Ncl. parasympaticus n. X (organs of neck, thorax, abdominal – to flexura coli sinistra!!!, genital glands) Sacral segments of spinal cord (S2-4), ncl. intermediolateralis (organs of pelvis except for genital glands) Paras. Ncl. GGl. Ggl.cervic.sup. N. V General organization of the parasympathetic ggl. Radix parasympathica Radix sympathica Radix sensoria Afferent Efferent CN III E-W afferents m. sph. pup. m. ciliaris m. dilat. pup. vessels Ggl. ciliare Ggl.cervic.sup. N. nasociliaris Ggl. ciliare Ggl. pterygop. CN VII ncl.sal. sup Nn. pterygop. Canalis pteryg. gl. lacrim. nasal, paranasal, pharyng., palatal glands Ggl.cervic.sup. SS + taste n. petr. major Ggl. pterygopalatinum n. petr. prof. Ggl. submand. CN VII ncl.sal. sup. N. lingualis lingual glands gl. submand. gl. subling. taste from tongue afferents from ant. 2/3 of tongue Ggl.cervic.sup. Chorda tymp. Ggl. submandibulare Plx. tympanicus Ggl. oticum Gl. parotis glands of cheeks Ggl. oticum CN IX ncl.sal.i nf. Ggl.cervic.sup. N. auriculotemporalis 3 SYMPATICUS - (cervico)-thoraco-lumbar system Ncl. intermediolateralis (C8 - L2) C8 - L2 – radix ant. sp. nerve n. spinalis tr. sympaticus r.comm. albus TRUNCUS SYMPATICUS ganglia trunci sympatici (paravertebral) cervicalia 3 (sup., med., inf.) thoracica 10-11 lumbalia 4-5 sacralia 4-5 ganglion impar rami interganglionares GANGLION TRUNCI SYMPATICI – eferent fibres rr.comm. grisei (to the n. spinalis - skin) rr. vasculares (net around the arteries) To the organs: rr. viscerales (postganglionic fibers) nn. splanchnici (praeganglionic fibers, praevertebral and intramural plexus) PARS CERVICALIS PARTIS SYMPATICAE Ganglion cervicale superius rr. comm. grisei - nn. spinales C1 –C4 n. jugularis (n.IX.,n.X.) rr. vasculares - n. caroticus int., ext. rr. viscerales - rr. laryngopharyngei n. cardiacus cervic.sup. Ganglion cervicale medium rr. comm. grisei - nn. spinales C5 –C6 rr. vasculares - pl. caroticus comm. rr. viscerales - gl. thyroidea, ggl. parathyroidae n. cardiacus cervic.med. Ganglion cervicale inferius rr. comm. grisei - nn. spinales C6 –C7 rr. vasculares - pl. subclavius rr. viscerales - gl. thyroidea, ggl. parathyroidae n. cardiacus cervic.inf. PARS THORACICA PARTIS SYMPATICAE rr. comm. grisei to all intercostal nerves rr. vasculares plexus aorticus thoracicus rr. viscerales nn. cardiaci thoracici (plexus cardiacus spf., prof.) rr. pulmonales (plexus pulmonalis) rr. oesophagei (plexus oesophageus) nn. splanchnici n. splanchnicus major Th6-9 (pl. coeliacus) n. splanchnicus minor Th10-11 (pl. coeliacus, pl. renalis) n. splanchnicus imus Th12 (plexus renalis) 4 PARS ABDOMINALIS ET PELVINA PARTIS SYMPATICAE rr. comm. grisei to all spinal nerves from L, S and Co segments nn. splanchnici lumbales (to plexus aorticus abdominalis) nn. splanchnici sacrales (to plexus hypogastricus) PRAEVERTEBRAL PLEXUSES – THORAX Plexus cardiacus spf., prof. Plexus pulmonalis Plexus aorticus thoracicus Plexus oesophageus Plexus aorticus abdominalis Plexus coeliacus (ggl coeliacum dx. sin.) plexus gastrici plexus lienalis plexus hepaticus plexus duodenalis plexus pancreaticus Plexus mesentericus superior Plexus mesentericus inferior Plexus renalis et suprarenalis (plexus uretericus) Plexus testicularis (ovaricus) Plexus iliaci (plexus femoralis) PRAEVERTEBRAL PLEXUSES – ABDOMINAL CAVITY Praevertebral ganglia Coeliacum dx. et sin. Mesentericum sup. Aorticorenale Mesentericum inf. PRAEVERTEBRAL PLEXUSES – PELVIS Plexus hypogastricus superior (n. praesacralis) Plexus hypogastricus dx. a sin. Plexus hypogastricus inf. plexus vesicalis plexus prostaticus plexus uterovaginalis plexus rectalis Plexus hypogastricus sup. Plexus hypogast. inf. 5 ■ relativelly independent (contraction of smooth muscles of the GIT tube and secretory activity of intramural glands) Enteric system Plx myentericus (Auerbachi) Plx submucosus (Meissneri) ■ neurons and interneurons in the GIT wall; ganglia ■ ganglia receive signals 1) from receptors in the intestinal wall 2) from CNS - symp. and parasymp. (modulation) ■ information conducted on interneurons – activation or inhibition of motorneurons in the intestinal wall ■ effectors: glands and smooth muscles in the intestinal wall Auerbach´s plexus stratum longitudinale stratum circulare l.muscularis mucosae Influence of sympatisus or parasympaticus Meissner´s plexus enteric VS neuron enteric interneuron motor neuron VISCEROSENSENSATION VS fibers originate as: 1) Mechanoreceptors physiological impulses and pain (only symp.) 2) chemoreceptors - pO2 (glomus caroticum) References: Putz, R. et al.: Atlas of Human Anatomy Sobotta. Elsevier Books, (2008). Netter, F. 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