Skin tumours
Hana Jedličková
I. Dept. dermatovenereology
St. Anna University Hospital

Skin tumours
nMalignant
nBenign
nNevi
nCysts, warts, scars
n




Malignant tumours - epithelial
nBasal cell carcinoma
nSquamous cell carcinoma
nActinic keratoses, cornu cutaneum
nMorbus Bowen
nKeratoacanthoma
nMorbus Paget

Basal cell carcinoma
nHereditary - Gorlin syndrome
nLong term UV exposition – actinic damage UVB (UVA)
nSun exposed areas - face













Squamous cell carcinoma
nActinic damage – face, scalp, dorsal aspects of the hands
nChronic wounds – ulcers, ca in lupo
nChronic dermatoses – lichen verrucosus
nTherapy side-effects – rtg, arsen, UV, cytostatics

Actinic keratoses






Morbus Bowen



























Keratoacanthoma



Morbus Paget



Malignant tumours non-epithelial
n
nMelanoma
nSarkomas
n     Kaposi sarkoma
n
nLymphomas
nHistiocytoses
n
n

Pigment cell nevus



Dysplastic nevi



Halo nevus



Malignant melanoma
nPhototype I, II
nFamiliar dysplastic nevi – mutations 9p21
nActinic damage - sunburn

Malignant melanoma
nABCD rule
nAsymetry
nBorder
nColour
nDiameter >5mm
nEvolution

Malignant melanoma
nSuperficially spreading
nNodular
nAcrolentiginous
nLentigo maligna melanoma

Malignant melanoma
nHistologic criteria
nBreslow  < 1mm, < 2mm, more
nClark I-V





































Lymphomas
nNodal – pruritus, infiltration, ichtyosis, immunosupresion (scabies)
nPrimary skin epidermotropic T cell
n     I.stage – chronic dermatitis
n     II. stage – skin infiltration
n     III. stage – tumours










B cell lymphoma



Kaposi sarkoma –  old men
                             - HIV positivity








Metastatic disease
nMelanoma
nSquamous cell carcinoma
nLung cancer - chest
nBreast cancer – chest, arms
nRenal tumours - scalp
nGIT tumours – navel (sister Mary Joseph nodule)













Paraneoplastic signs
nIchtyosis
nPruritus
nKeratoderma palmoplantar
nDermatomyositis
nBullous pemphigoid
nAcanthosis nigricans
n