1. Test ND3

- revision of the 9th -13th topics

2. Correctly assign the following terms to the diagram:

Positive, absorption, pharmaceutical/incompatibilities, summation, metabolism, antagonism, pharmacodynamic, negative, distribution, potentiation, elimination, pharmacokinetic, synergism

Overview of drug interactions

3. Suggest groups of patients who are at higher risk of interactions and justify the reasons 

Risk groups of patients in terms of interactions - discuss the reason and consequences

4. Categorize the examples of drug interactions to the specific types in the table

5. Case reports

• study it carefully
  
• try to identify the drug problem yourself or check whether all drug-related problems were identified by your colleagues
• classify this interaction/drug problem (AE/pharmacokinetic/pharmacodynamic/combined IT)
• evaluate whether the drug problem was solved correctly, or suggest an alternative solution
• try to evaluate whether the drug problem was preventable or not
• verify/identify  this interaction/drug problem in the available database
• compare the classification - level of significance 

6. Think about the examples of drug combinations listed below. 

Identify the combinations of drugs in available databases or the Summary of Product Characteristics, respectively. 

Classify the interaction (Biopharmaceutical/PK/PD, preventable/unpreventable, beneficial/undesirable, and grade the level of significance - 1-5 or  Unknown/ Moderate/Major/Contraindicated                                     

• doxycycline x antacids
  
• atorvastatin x clarithromycin
• voriconazole x haloperidole
• warfarin x fluconazole
• rifampicin x fentanyl 
  
• amiodarone x moxifloxacine
• rifampicin x lamotrigine 
• verapamil x bisoprolol

7. Discuss approaches for clinical practice, which could prevent dangerous drug-drug interactions