CHRCjJIUM
Michaela Králíková, MD
Department of Biochemistry
Faculty of Medicine
Masaryk university
i
• Cr"  - toxic (mutagenic, carcinogenic and lipoperoxidation agent)
■> CrJJJ - rjscsssijry io jrjsurs opiinml
* concentration /S, P    0.05 - 0.5 ug/l
1-10 nmol/l
/B        0.7 - 28 ug/l
13.4 -538 nmo J/J
2
Metabolism
•  RDI for females 70-130 ug/d, males 80-150 ug/d
•  absorption 0.04 - 2%
•  in plasma binds to albumin, transferrin and globulins
•  urinary excretion    0.1 - 2.0 jig/l = 1.9 - 38.4 nmol/l
t in physical activity, pregnancy, lactation, high sugar intake
3
Function
•  CH"
•  i lipoperoxidation, participation in saccharides, lipids and proteins metabolism via regulation of insulin action
•  peptide chromodulin (4 Cr):
•  binds IC part of insulin receptor after insulin —► tyrosinkinase activation —► potettimiJori
of insulin effects
4
Deficiency
hyperglycaemia irresponsive to insulin glycosuria
peripheral neuropathy hyperlipidemia
5
Toxicity • occurs in environmental pollution
•  alergie eczema, skin ulcers; bronchogenic carcinoma or other tumors
*  contaminant iru parenteral solutions