MANGANES
Michaela Králíková, MD
Department of Biochemistry
Faculty of Medicine
Masaryk University
• 12 - 20 mg in organism, predominantly in mitochondria		
• Mn/S ■ 7-	27 nmol/l	
0.5	-1.5 iJLg/l	
• RDI		
• 2 - 5 mg /d		
• tea, grains, cocoa, nuts, blueberries		ginger, parsley, 2
•  Absorption: 3-5%
•  Transport:   in plasma bound to a-2-
macroglobulin, in eres to Hb, in liver to transferrin and transmanganin
•  Exertion:    faeces: 0.8 -1 jig/d (bile, pancretic
and shed-mucosal Mn) urine: 0.1 -1.4 jag /kg /d
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Function
glukosaminoglykans synthesis (bones and cartilages)
mitochondrial Mn-SOD 2 (Mn2+ <-► Mn3+)
pyruvate carboxylase, arginase, ALP
cholesterol synthesis
synthesis and activation of protrombin
insulin synthesis
participation in oxidative phosphorylation
Dt 1 iency
bone defects skin changes neurological symptoms cot   jlation disorders disorders in lipoprotein formation
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Toxíny
•  in workmen with manganese ore, KMn04 poisoning
•  orally: emesis, diarrhoea
•  inhalation : pneumonia, irreversible affection of basal ganglia
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