l,3-1,8iimol/l 95-140ug/l
jinal deficiency ([ content in soil 100 \igiwľ^
50 - 70 Lig/I (í
dis.)
20 - 50 ng/l
/I (deficiency dis.)
JÍ íl
Absorption
76 -100%; duodenum and jejunum
Transport and distribution in organism
nd then is built into as Se-Cys
ie liver —► in inappropriate
selenoprotein
l_—I
Excretion
50 - 60% urine
faeces
o>
eins
Glutathion-peroxidase (GPx)
►:<•!•]
peroxiae
ONOO" + 2 GSH peroxonitrite
ttlU
alcohol
NO, + H,0 + GS
Gj
Sperm selenoproteins in DNA and mtch
Deiodinase
»m.
ü
vlr1
31C"
activatio
ion o
nd in
oid horm ivation)
IÍTZ
eins
Selenoprotein P
rotects endotelial cells from peroxonitrite
•
Other selenoproteins with or without tissue spechHy (a number of 10)
Thioredoxin reductase (TR)
(thioredoxms Trx- enzymes with disulphide bond, oxid o reductases:
7
Thioredoxin reductase function
regeneration of
Trx-S2 + NADPH + H+   ■*    Trx-(SH)2 + NADP+
spont. Trx-(SH)2 + Protein-S2   ■*    Trx-S2 + Protein-(SH)2
reduction of SeO,2-
R
Se032 + 3 NADPH + 3 H+ ■*   Se2 + 3 NADP++3 H20
reduction of hydroperoxides, selenodiglutathion, lipoic and dehydroascorbic acid, vit. K and alloxans
e- donor for pGPx
mpofízinsB us u
Antioxidative protection (GPx; cardiovascular diseases, cancer, cognitive function)
Synthesis of eicosanoids
une reactions, I
,--„,    -, --, -    ,, ana organic carcinogenic substances deactivation
Regulation of action of thyroid hormones (deiodinase)
Necessary for reproduction (selenoproteins)
I1UJ1
Clinical symptoms
Muscular weekness, pain and asthenopia
Depigmentation and other defects of hair, skin and nails
Macrocytosis
Oxidative stress
11
Keshan diseas
kardiomyopathy, muscular affection Keshan region in middle China, New Zealand
Kashin-Beck disease
osteoarthropathy, China
matou s kretenism