Adobe Systems Physiology department 1 Anthropometric parameters measurement Adobe Systems Physiology department 2 Adipose tissue ̶White (for storing dietary energy as TAGs) ̶Brown (for ability to convert chemical energy into heat) ̶Beige = harbored Adobe Systems Physiology department 3 Fat tissue functions ̶Thermogenesis ̶Lactation ̶Immune responses ̶Fuel for metabolism ̶ Adobe Systems Physiology department 4 Structure of adipose tissue ̶Adipocytes ̶Non-fat cells: ̶inflammatory cells (macrophages) ̶immune cells ̶preadipocytes ̶fibroblasts ̶Connective tissue matrix ̶Vascular tissue ̶Neural tissue Adobe Systems Physiology department 5 Abdominal fat The abdominal fat is present in two main depots: ̶Subcutaneous (80% of all body fat) ̶Intra-abdominal (10–20% of total fat in men and 5–8% in women) Adobe Systems Physiology department 6 Adipocytes ̶New smaller adipocytes act as a buffers. They are more insulin-sensitive and have high avidity for FFAs and TGs uptake, preventing their deposition in non-adipose tissue (SCAT) ̶Large adipocytes are insulinresistant, hyperlipolytic and resistant to anti-lipolytic effect of insulin (VAT) Adobe Systems Physiology department 7 Clinical and prognostic differences ̶Metabolic risks ̶Metabolic syndrome ̶Vascular risk and cardiovascular events ̶Prediction of mortality ̶ Adobe Systems Physiology department 8 Anthropometric indexes of abdominal adipose tissue mass ̶WHR ̶Waist circumference ̶Abdominal sagittal diameter* 008 Waist circumference (cm) Category Men Women Normal value ≤ 94 ≤ 80 Necessity to decrease body mass 95–102 81–90 Medical assistance with decreasing of body mass necessary > 102 > 90 WHR: for women < 0.80 for men < 1.00 Adobe Systems Physiology department 9 Imaging techniques ̶Computed tomography (CT) Abdominal sagittal diameter* ̶L4 – L5 region ̶V/S ratio ̶V/S≥0.4 (V group) ̶V/S<0.4 (SC group) Adobe Systems Physiology department 10 Imaging techniques ̶Computed tomography (CT) ̶Magnetic resonance imaging (MRI) ̶Ultrasound (US)* Adobe Systems Physiology department 11 Bioimpedance measuring ̶Bioimpedance spectroscopy (BIS) ̶Bioelectrical impedance analysis (BIA) Adobe Systems Physiology department 12 Indexes calculated from anthropometric parameters Obesity degree % ideal body mass mild 115–129 moderate 130–149 severe 150–199 morbid > 200 Waist circumference (cm) Category Men Women Normal value ≤ 94 ≤ 80 Necessity to decrease body mass 95–102 81–90 Medical assistance with decreasing of body mass necessary > 102 > 90