Electrophysiology of Cell Membranes
Electrical Excitability, Action Potentials
Synaptic Transmission, Neuromuscular Junction
Physiology of Skeletal, Cardiac and Smooth Muscle Cells
Physiology of Cells II.
Electrophysiology of Cell Membranes
➢ Ionic Basis of Membrane Potentials
• Transport of ions across membranes
• Ionic channels – structure and function, selectivity, gating
• Membrane potential is genereted by ion gradients
(equilibrium potential, resting membrane potential)
➢ Measurement of Ionic Currents
Electrical Excitability, Action Potentials
➢ Electrical Excitability (threshold, electrotonic potential, local response)
• Phases
• Ionic base (voltage-gated vs. other subtypes of ionic channels)
• Pathophysiology – first remarks
➢ Action Potential (neuron, skeletal muscle, cardiac muscle)
➢ Propagation of Action Potentials (local current loops, myelin sheet, gap
junctions)
Synaptic Transmission
➢ Electrical vs. Chemical Synapses
• Structure, Classification (according to place and response)
• Neurotransmitters – Types, Mechanisms of Action
• Summation of Information from Individual Synapses
➢ Chemical Synapses
➢ Neuromuscular Junction (structure, function, endplate potential)
Physiology of
Skeletal, Cardiac and Smooth Muscle
➢ Structure
➢ Origin of Electrical Excitation
➢ Action Potential Configuration, Ionic Base
➢ Excitation – Contraction Coupling
➢ Regulation of the Force of Contraction