1 Basic Clinical Radiobiology To learn the fundamental radiobiology principles related to patient treatment. This knowledge provides rationale for daily decisions in clinical practice. 2 Target groups •Students of Medical physics, Radiobiology and related fields • •Students of MUNI who can benefit from understanding basics of radiobiology (e.g., radiation protection officers) and clinical practice (e.g., physicians and radiographers) 3 Course Aim •Provide an introduction to radiobiology and radiation oncology • •Cover basic mechanisms of cell death and general radiation response of cancerous and non-cancerous cells to radiation • •Describe the current approaches to various radiotherapy modalities and discuss possible future approaches (e.g., FLASH RT) 4 Teachers 1. A.Kurzyukova „Cancer cell biology & radiation-induced molecular effects“ 1. 2. A.Kurzyukova „Radiation effects on tumor cells and microenviroment & radioresistance“ 3. A.Odlozhilikova „Introduction to Radiobiological Modelling in Radiation Therapy “ 4. B.Odložilík „Basic radiobiology and introduction to FLASH“ 5. B.Odlozilik „Laser-based particle acceleration and experiments“ 6. S.Bazhukov „Radiopharmaceuticals production“ 7. I.Bazhukova „Radionuclide therapy with radiopharmaceuticals“ 8. I.Bazhukova „Radiomodifiers in radiation therapy“ 5 6 7 8 9 10 Teaching Methods •8 hours of lectures •8 tests after each of lectures Learning Outcomes: By the end of this course participants should be able to have the basic knowledge of radiobiology necessary for working in the field of Radiation Oncology.