Applied and Clinical Pharmacology
Applied and Clinical Pharmacology

Clinical pharmacology of antithrombotics

This week, we will again focus on a specific group of drugs - namely antithrombotics and their clinical pharmacology: dosage in individual indications, duration of treatment, combinations. It's all part of the pre-class reading (chapter 10 of the book). The link is here:

Clinical pharmacology of antithrombotics

In the individual application exercises of the pre-class reading, you were also able to test your dose adjustment skills in renal insufficiency.

Have you also tried to think about the therapy in Example 1: dosing of enoxaparin in a therapeutic indication - treatment of deep vein thrombosis - in a patient with a body weight of 63 kg?

Try looking in the guidelines or SmPC for how long the patient should be treated. The patient has a history of an eight-hour flight three days ago with pain and unilateral left lower extremity swelling lasting two days.

The standard dose would correspond to 0.6 ml every 12 hours, an option would be to use the Forte form in one daily dose. Further data from the patient's medical history is missing, so we cannot decide on a possible dose reduction or bleeding risk.

Regarding the length of treatment, for example, the ESVS 2021 Management Guidelines for Venous Thrombosis recommend 3 months for provoked proximal DVT rather than shorter therapy. 

Other guidelines may refer to a different length of therapy. But did you understand what the guidelines recommend? Would you be able to apply them in practice?

Test your knowledge after reading the pre-class reading chapter. 

Try taking the ROPOT test here:

Clinical pharmacology of antithrombotics

And now you can look forward to the TBL lesson where we will focus on the reasonable use of antithrombotics in a virtual patient.

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