FEMALE REPRODUCTIVE SYSTEM II • vagina (vagina, kolpos) • external genitalia (vulva) • labia maiora et labia minora pudendi • clitoris • vestibulum vaginae • vestibular glands • hymen • accessory embryonic organs - funiculus umbilicalis - placenta Vagina - HES stratified squamous epithelium lamina propria Vagina venules no glands lamina propria smooth muscles stratified squamous epithelium epithelial cells – glycogen (+ Lactobacillus acidophilus)→lactic acid /pH 3.8-4/ Vagina – Best´s carmine basal cells superficial cells with glycogen papillae of lamina propria mucosae Labium minus (HE) – external genital organ inner (medial) side outer (lateral) side centre - connetive tissue sebaceous glands sebaceous glands epidermis epidermis Labium minus duct opens directly into epidermis sebaceous glands dermis epidermis 40-50 cm Funiculus umbilicalis (HE, HES, AZAN) magn:2,5 magn:2.5 from APERIO vein artery artery Funiculus umbilicalis (AZAN) – amniotic ectoderm Wharton´s jelly collagen fibers – blue, nuclei of fibroblasts - violet Placenta • Pars materna – basal plate with placental septs • Pars fetalis – chorionic plate with chorionic villi /stem and free/ s: 15-25 cm t: 2.5-4 cm w: 500-600 g 25-30% of uterine cavity - discoidalis - olliformis - hemochorialis http://www.odec.ca Human placenta (HES) – pars fetalis chorionic plate stem villus stem villus chorionic villi Human placenta (HES) – pars materna basal plate – decidua basalis chorionic villi stem villus Human placenta (HE) connective tissue fibrinoid fetal vessels chorionic villi Human placenta (HE) – placental barrier cytotrophoblast (Langhans cell) fetal vessels fibrinoid maternal blood FEMALE REPRODUCTIVE SYSTEM II Slides: 49. Vagina – glycogen /Best´s carmine/ 50. Vagina 51. Labium minus 99. Funiculus umbilicalis /HE, HES, AZAN/ 100. Placenta Embryologic schemes: •Indifferent gonad •Differentiation into testis, differentiation into ovary Atlas EM: •Development of gonads (95) •Development of genital passages and external genitalia (96) Development of gonad • indifferent gonad to 6th-7th week of development – germ cell (wall of yolk sac) – genital (gonadal) ridge – mesoderm – coelomic epithelium – mesoderm – primitive sex cords http://quizlet.com/15832386/tamhsc-development-of-genital-system-flash-cards/ Development of gonad – Human embryo (6th week) aorta gut mesenteriuma. mes.inf. Development of gonad - differentiation to ovary – 2 generations of cords • medullary disappers • 7th week – cortical cords arise →form follicles, remain close to the surface – germ cells →oogonia 7 weeks http://www.embryology.ch/anglais/ugenital/diffmorpho03.html Development of gonad – Human embryo (8th week) female http://www.theodora.com germinative epithelium Development of gonad - differentiation to testis 7 weeks 8 weeks http://www.embryology.ch/anglais/ugenital/diffmorpho02.html - 1 generation of genital cords, separating from the coelomic epithelium Development of gonad – Human embryo (8th week) male Development of genital ducts • indifferent stage – mesonephric duct (Wolffian) – paramesonephric duct (Müllerian) – longitudinal invagination of coelomic epithelium at the urogenital cord Differentiation towards male sex towards female sex mesonephric duct – Wolff paramesonephric duct - Müller - vertical - horizontal do not fuse →uterine tube - vertical - both ducts fuse → uterovaginal primordium – uterus and cranial part of vagina Development of the vagina Development of external genitalia • indifferent stage – cloacal folds around the cloacal membrane →anteriorly urethral (urogenital) folds →posteriorly anal folds – genital tubercle (phallus) – genital swellings cloacal membrane Development of external genitalia - differentiation anal membrane urogenital membrane - genital tubercle →clitoris - urethral (urogenital) folds →labia minora - genital swellings (tori genitales) →labia maiora FEMALE MALE - genital tubercle →penis - urogenital folds fuse →pars spongiosa urethrae m. - genital swellings fuse →scrotum Development of external genitalia – Human embryo (8th week) female folds swellings s f