1.      Coagulation cascade


Fill in the blanks in the scheme below (coagulation components – blue boxes, haemocoagulation tests
– red boxes)

help: https://www.youtube.com/watch?v=MRqcgYdB5Ng





endothelial cell damage

                                           tissue damage




         X                        Xa                       X

                                        tissue factor (III)

                                               VIIa

                                       tissue phospholipids

prothrombin (II)

                                               XIII


                                               XIIIa

                                               Ca^2+


                                               Ca^2+


                                               Ca^2+


fibrinogen (I)



                                               Ca^2+






antithrombin































a)      Which of the following coagulation factors are dependent on the presence of vitamin K?


b)     Which factor connects the internal and external pathways of haemocoagulation?


c)      Give examples of drugs that interfere with the coagulation cascade by their mechanism of
action. Arrange the names of these drugs in the coagulation cascade scheme (green boxes) above.


Select drugs from the following list: apixaban, enoxaparin, dabigatran, heparin, clopidogrel,
warfarin


2.      Give the names of the drug groups influencing the blood clotting processes (blue fields)
and their representatives:






3.      Divide the drugs into pharmacotherapeutic groups and complete the tables below:

alteplase, cilostazol, dabigatran, enoxaparin, eptifibatide, etamsylate, heparin, clopidogrel, ASA
(aspirin), tranexamic acid, rivaroxaban, terlipressin, ticagrelor, tissue sealants, warfarin

A.     Drugs inhibiting haemocoagulation

Pharmacological class

                     Mechanism of action

                                        Drug representatives

Anticoagulants










Fibrinolytics



Antiplatelet drugs












B.      Drugs enhancing haemocoagulation

Pharmacological class

                     MoA

                        Drugs

Antifibrinolytitics



Haemostatics