ASSAY      Marianna Christodoulidou-F16183

Analyt: Sodium Carbonate Decahydrate


Volumetric solution: 1M Hydrochloric acid

Titre of volumetric solution: 1.0054

Type of titration: Acid base titration


                                           Titration No.

                                m [g] (4 decimal places) or V [ml]

                                      Consumption of VS [ml]

                                               ASSAY

                                                1.

1.0111g

6.98ml

36.78

                                                2.

1.0054g

6.75ml

35.77

                                                3.

1.0068g

6.55ml

34.66

                                                4.

1.0005g

6.52ml

34.72

                                                                                            Average

35.48


STATISTICAL EVALUATION:

Range:
      R = Xmax-Xmin= 36.78-34.66= 2.12

Standard deviation (estimated from range):                         sd = Kn*R = k4*2.12=
0.4857*2.12= 1.0297

Relative standard deviation:                                                        RSD
=(SD/AVERAGE)*100 =               (1.0297/35.48)*100= 2.9022

Equations for Assay:

1)       𝑥 (%)= (V∗f∗m∗100)/q

X=(6.98ml*1.0054*52.99mg*100)/1011.1mg

   =36.78



2)      𝑥 (%)= (V∗f∗m∗100)/q

X=(6.75*1.0054*52.99*100)/1005.4 =35.77

3)      𝑥 (%)= (V∗f∗m∗100)/q

X=(6.55*1.0054*52.99*100)/1000.5 = 34.72


CONCLUSION (does your sample meet/not meet Ph. Eur).:

I think it doesn’t meet pharmacopeia because our content is says that Na2CO3 is about 36.7-40% but
we found just one sample at this range, the rest are lower. Our average is 35.48% is lower than the
above range. So maybe it doesn’t meet pharmacopeia.