NAME: Filippos Chatzittofi F16190

SAMPLE: Sodium Bromide

1)      IDENTIFICATION REACTIONS OF IONS

-          CATIONS (describe briefly reactions):  Sodium

Dissolve 0,1g of the substance to be examined in 2 ml of water R or use 2ml of the prescribed
solution.  Add 2ml of 150g/L solution of potassium carbonate R and heat to boiling.  No precipitate
is formed.  Add 4ml of potassium pyroantimonate solution R to hear boiling.  Allow to cool in iced
water and if necessary, rub the inside of the test tube with a glass rod.  A dense white
precipitate is formed.

-          ANIONS (describe briefly reactions): Bromide

Dissolve in 2ml of water R a quantity of the substance to be examined equivalent o about 3mg of
bromide or use 2ml of the prescribed solution.  Acidify with dilute nitric acid R and add 0,4ml of
silver nitrate solution R1.  Shake and allow to stand.  A curdled, pale yellow precipitate is
formed.  Centrifuge and wash the precipitate with three quantities, each of 1ml, of water R.  carry
out this operation rapidly in subdued light sidregarding the fact that the supernatant solution may
not become perfectly clear.  Suspend the precipitate obtained in 2ml of water R and 1,5ml ammonia
R. the precipitate dissolves with difficulty




2)      ASSAY

Volumetric solutions:   0,1M AgNO3

Titre of volumetric solutions:  0,1 M AgNO3 0.9998

0,1 M NH4SCN 0.9897

                                           Titration No.

                                     m [g] (4 decimal places)

                                      Consumption of VS [ml]

                                               ASSAY

                                                1.

1.9854

14.57

54,81

                                                2.

1.8954

14.98

55,20

                                                3.

2.0045

14.69

53,675

                                                4.

2.0215

14.68

53,27

                                                                                            Average

54,24

CALCULATION PROCEDURE: f1=0,9998    f2=0,9897    m=10,29    v1=25ml

ASSAY 1:

Q=1,9854 but in 10ml=198,54mg

V2=14,57ml

X(%)=(25ml*0,9998-14,57ml*0,9897)*10,29*100/198,54

X(%)= 54,81%


ASSAY 2:   Q=1,8954 in 10 ml = 189,54ml

V2=14,98

X(%)= (25ml*0,9998-14,98ml*0,9897)*10,29*100/189,54

X(%)=55,2%

ASSAY 3: Q=2,0045 in 10 ml= 200,45mg

V2=14,69

X(%)=(25ml*0,9998-14,69*0,9897)*10,29*100/200,45

X(%)=53,675


ASSAY 4:Q=2,0215 in 10ml= 202,15mg

V2=14,68

X(%)=(25ml*0,9998-14,68*0,9897)*10,29*100/202,15

X(%)=53,27




STATISTICAL EVALUATION:

Range:
      R = xmax – xmin= 55,20-53,27=1,93

Standard deviation (estimated from range):                         sd = K4*R= 0,4857*1,93=0,937

Relative standard deviation:                                                        RSD
=(sd/average)*100=

0,937/54,24*100=1,7282




CONCLUSION (does your sample meet/not meet Ph. Eur):  no it does not meet ph.eur because is ours is
just 54,24 less than pharmacopoieia.