Dear colleagues, dear students,
Find attached some interesting materials with the topic of contraception and osteoporosis. Topics closely related to
the level of female hormones.
Recommended procedure for self-study:
a) To properly understand the principles of functioning of medicines, repeat the physiology of hormone levels see,
for example, the following videos, or read any sources of your choice
b) Go through the presentation
c) Try to think about the attached case studies
PharmDr. Martin Šimíček
1. Contraception:
Before reading the presentation, I recommend some materials or videos where you can repeat the basics of
physiology in a simple way, which is the basis of our knowledge of where different types of hormonal contraception
interfere with the physiological cycle of sex hormone levels:
Estrogen Reproductive system physiology https://www.youtube.com/watch?v=2_owp8kNMus
How Birth Control Pills Work, Animation https://www.youtube.com/watch?v=hI2C7TsnSfk
How does morning after pill work? Postinor/Escapelle https://www.youtube.com/watch?v=hI2C7TsnSfk
Intrauterine device https://www.youtube.com/watch?v=ES_JBy-LonY
2. Osteoporosis:
Pathophysiology
The videos produced by the company Amgen, which produces an antibody against osteoporosis - denosumab, have
illustrative videos:
Introduction to bone biology https://www.youtube.com/watch?v=inqWoakkiTc
Osteoblasts and Osteoclasts https://www.youtube.com/watch?v=78RBpWSOl08
Regulation of Osteoclast Activity https://www.youtube.com/watch?v=GpMV197xZXc
Finally, a great video describing the mechanism of osteoporosis, the mutual (in) balance between osteoblasts and
osteoclasts, including individual mediators, attractive animation (in English)
https://www.youtube.com/watch?v=VwCkyf0lQwo
Vitamin D metabolism https://www.youtube.com/watch?v=EaCfFbZvGIM
https://www.youtube.com/watch?v=YEnxruA-bsk
Endocrinology - Calcium and Phosphate Regulation https://www.youtube.com/watch?v=EEM0iRJNhU8
Denosumab (Prolia) https://www.youtube.com/watch?v=BLQpUroOwRg
Diagnostics - densitometry https://www.youtube.com/watch?v=iEbvMMquMYg
https://www.youtube.com/watch?v=heTObdmOU8o
Risk factors for osteoporosis https://www.youtube.com/watch?v=uvltEnSQ0ZY